Abstract
Small intestine submucosa (SIS) derived from the submucosal layer of porcine intestine cause minimum immune response as acellular collagen based matrix1,2 and moreover is a biodegradable.3 SIS consists of types I and III collagens above 90% and small amounts of types IV, V, and VI collagens.4 In addition, SIS contains a wide variety of cytokine such as basic fibroblast growth factor (bFGF), transforming growth factor-β (TGF-β), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), and insulin-like growth factor-1 (IGF-1) as well as glycosaminoglycans, fibronectins, chondroitin sulfates, heparins, heparin sulfates, and hyaluronic acids.5,6 These constituents are well known to play an important role for tissue remodeling and wound healing. SIS has been used as commercial goods in practical biomedical fields such as the repair of numerous body tissues including musculotendinous structures, lower urinary tract reconstruction, dura mater replacement, vascular reconstruction, and the repair of full and partial thickness skin wounds.7–9
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Kim, M.S. et al. (2006). Preparation of Sponge Using Porcine Small Intesinal Submucosa and Their Applications as a Scaffold and a Wound Dressing. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_15
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DOI: https://doi.org/10.1007/978-0-387-34133-0_15
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