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“Stem Cells into Liver” - Basic Research and Potential Clinical Applications

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Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 585))

Abstract

Regenerative medicine holds promise for the restoration of damaged tissues and organs. The concept of regenerative medicine radically changed when pluripotent human embryonic stem cells were isolated and cultured1. However, much more promising perspectives for clinical application are served by recently discovered multipotential adult stem cells, which may give rise to a large family of descendants, depending on the environments they are residing in2,3,4. Properties and plasticity of stem cells from different sources have been intensely investigated, regarding to their use in therapy. The liver is one target for which development of stem cell-based therapy is of great significance. Even though an injured liver is highly regenerative, many debilitating diseases lead to hepatocyte dysfunction and organ failure.

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Authors and Affiliations

  1. Section for Studies on Metastasis, National Cancer Center Research Institute, Tokyo, Japan

    Agnieszka Banas, Gary Quinn, Yusuke Yamamoto, Takumi Teratani & Takahiro Ochiya

  2. Effector Cell Institute, Inc., Tokyo, Japan

    Gary Quinn

  3. Department of Biology, School of Education, Waseda University, Tokyo, Japan

    Yusuke Yamamoto

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  1. Agnieszka Banas
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  2. Gary Quinn
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  4. Takumi Teratani
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  1. University of Maryland, College Park, MD, 20742, USA

    John P. Fisher

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Banas, A., Quinn, G., Yamamoto, Y., Teratani, T., Ochiya, T. (2006). “Stem Cells into Liver” - Basic Research and Potential Clinical Applications. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_1

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  • DOI: https://doi.org/10.1007/978-0-387-34133-0_1

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