Endometrial biopsies and curettings are among the most common tissue specimens received in the pathology laboratory. In several respects these specimens present a unique challenge for the surgical pathologist. The normal endometrium undergoes a variety of morphologic changes, especially during the reproductive years, when cyclical hormonal influences and pregnancy affect uterine growth. Biopsyinduced artifacts confound this heterogeneous group of morphologic changes. Whether the biopsy is limited or a thorough curettage, the procedure usually is “blind,” with no visualization of the tissue sampled. The final specimen contains multiple, irregularly oriented tissue fragments mixed with blood and contaminatingcervical tissue and mucus.
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Mazur, M.T., Kurman, R.J. (2005). Introduction. In: Diagnosis of Endometrial Biopsies and Curettings. Springer, New York, NY. https://doi.org/10.1007/978-0-387-26321-2_1
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