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The Role of Epigenetic Dysregulation in Suicidal Behaviors

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Behavioral Neurobiology of Suicide and Self Harm

Part of the book series: Current Topics in Behavioral Neurosciences ((CTBN,volume 46))

Abstract

Suicidal behaviors have been associated with both heritable genetic variables and environmental risk factors. Epigenetic processes, such as DNA methylation, have important roles in mediating the effects of the environment on behavior. Dysregulation of these processes has been observed in many psychiatric disorders, and evidence suggests that they may also be involved in suicidal behaviors. Herein, we have summarized candidate gene and epigenome-wide studies which have investigated DNA methylation in relation to suicidal behaviors, as well as discussed some of the limitations of the field to date.

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Authors and Affiliations

  1. McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Verdun, QC, Canada

    Laura M. Fiori & Gustavo Turecki

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  1. Laura M. Fiori
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  2. Gustavo Turecki
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Correspondence to Gustavo Turecki .

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  1. Fundacion Jimenez Diaz Psychiatry Department, Universidad Autonoma de Madrid, Madrid, Spain

    Enrique Baca-Garcia

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Fiori, L.M., Turecki, G. (2020). The Role of Epigenetic Dysregulation in Suicidal Behaviors. In: Baca-Garcia, E. (eds) Behavioral Neurobiology of Suicide and Self Harm. Current Topics in Behavioral Neurosciences, vol 46. Springer, Cham. https://doi.org/10.1007/7854_2020_160

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