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Hemolymphoproliferative Diseases and Treatment-Related Disorders

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Pediatric Neuroradiology

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Abstract

Pediatric hemolymphoproliferative diseases (HLDs) are a constellation of disorders that prominently include leukemia, lymphoma, and histiocytoses. These conditions are invariably severe, and are burdened by elevated morbidity and mortality in the absence of proper treatment. HLDs are systemic disorders, i.e., they typically affect multiple organs and systems in the human body. While, as a whole, leukemia and lymphomas account for about 40% of all malignancies in children [1], the majority of histiocytoses are not malignant. Intensive treatment regimens have resulted in a significant increase in the number of survivors, but have also disclosed new phases of the natural history of these disorders, among which is involvement of the central nervous system (CNS). CNS disease is not consistent, but when present, it is commonly associated with worsened prognosis. Moreover, current treatment modalities, including systemic therapy (i.e., combination chemotherapy) and specific CNS prophylaxis (i.e., intrathecal chemotherapy with or without cranial irradiation), are potentially neurotoxic.

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Authors and Affiliations

  1. Department of Pediatric Neuroradiology, G. Gaslini Children’s Research Hospital, Genoa, Italy

    Paolo Tortori-Donati MD (Head), Andrea Rossi MD (Senior Staff Neuroradiologist) & Roberta Biancheri MD, PhD (Consultant Child Neurologist)

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  1. Paolo Tortori-Donati MD
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  2. Andrea Rossi MD
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  3. Roberta Biancheri MD, PhD
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Tortori-Donati, P., Rossi, A., Biancheri, R. (2005). Hemolymphoproliferative Diseases and Treatment-Related Disorders. In: Pediatric Neuroradiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3-540-26398-5_11

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