J Korean Med Sci. 2000 Oct;15(5):545-550. English.
Published online Apr 27, 2009.
https://doi.org/10.3346/jkms.2000.15.5.545
Published online Apr 27, 2009.
https://doi.org/10.3346/jkms.2000.15.5.545
Copyright © 2000 The Korean Academy of Medical Sciences
Original Article
Sebaceous carcinoma of the eyelids: frequent expression of c-erbB-2 oncoprotein
Kyung Ja Cho,
Shin Kwang Khang,
Jae Soo Koh,*
Jin Haeng Chung,*
and Seung Sook Lee*
Abstract
Ocular sebaceous carcinoma (OSC) is an uncommon malignancy with a potential to recur and metastasize. Some characteristics of sebaceous carcinoma, such as female preponderance, shown in the present series during 11-year period at Korea Cancer Center Hospital, led us to study their hormone receptors and c-erbB-2 expression. c-erbB-2 overexpression was very common (83%) in OSC, and was not associated with pathologic findings or clinical outcome. Interestingly, estrogen and progesterone receptor was detected in 4 and 2 cases, respectively, suggesting a role of hormonal influence on this neoplasm. Immunohistochemical and clinicopathologic features of 18 cases of OSC in Korea are presented.
Keywords
Carcinoma; Sebaceous Glands; Eyelids; Immunohistochemistry; erbB-2; Receptors, Estrogen; Receptors, Progesterone
MeSH Terms
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