Skip to main content
SpringerLink
Log in

Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach

Results of a controlled clinical trial

  • Original Article
  • Published:
Medical Oncology Aims and scope Submit manuscript

Abstract

Treatment of patients with early stage gastric mucosa-associated lymphoid tissue (MALT) remains undefined. We began a controlled clinical trial to evaluate efficacy and toxicity of the most common therapies. Two hundred and forty-one patients with gastric low-grade MALT lymphoma in early stage (IE and IIE) were randomized to surgery (80 cases), radiotherapy (78 cases), and chemotherapy (83 cases). With a median follow-up of 7.5 yr, actuarial curves at 10 yr showed that event-free survival was 52% in patients treated with surgery, 52% in radiotherapy arm, and 87% in the chemotherapy group (p<0.01). However, overall survival did not showed any statistical differences: 80%, 75% and 87%, respectively (p=0.4). Acute and late toxicities were mild. No death-related treatments were observed. No clear differences were observed between the most common therapies in patients with primary gastric MALT lymphoma in early stages, probably because this type of lymphoma has an high response rate to salvage treatment after failure to local treatment (surgery and radiotherapy). Thus considered, chemotherapy alone is an effective and safe therapeutic approach in this setting of patients. Surgery or radiotherapy will be reserved to patients that are not candidates for chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Maes B, De Wolf-Peeters C. Marginal zone-cell lymphoma. An update on recent advances. Histopathology 2002;40:117–126.

    Article  PubMed  CAS  Google Scholar 

  2. Pileri SA, Zinzani PL, Went P, Pileri A Jr, Bendani M. Indolent lymphoma. The pathologist’s point of view. Ann Oncol 2004;15:12–18

    Article  PubMed  CAS  Google Scholar 

  3. De Jong D, Boot H, van Herdee P, Hart GAM, Taal BG. Histological grading in gastric lymphomas. Pretreatment criteria an clinical relevance. Gastroenterology 1997;112:1466–1474.

    Article  PubMed  Google Scholar 

  4. Fung CY, et al. Mucosa associated lymphoid tissue lymphoma of the stomach. Cancer 1999;85:9–17.

    Article  PubMed  CAS  Google Scholar 

  5. Tadashi Y, et al. Clinicopathological features of gastric mucosa associated lymphoid tissue (MALT). High-grade transformation and comparison with diffuse large B-cell lymphomas without MALT lymphoma features. J Clin Pathol 2000;53:187–194.

    Article  Google Scholar 

  6. Fischbach W, et al. Primary gastric B-cell lymphoma. Results of a prospective multicenter study. Gastroenterology 2000;119:1191–1202.

    Article  PubMed  CAS  Google Scholar 

  7. Koch P, et al. Primary gastrointestinal non-Hodgkin’s lymphoma: combined surgical and conservative or conservative management in localized gastric lymphoma. J Clin Oncol 2001;19:3874–3883.

    PubMed  CAS  Google Scholar 

  8. Vaillart JC, et al. Management and long-term results of surgery for localized gastric lymphomas. Am J Surg 2000;179:216–221.

    Article  Google Scholar 

  9. Montalban C, et al. Gastric B-cell mucossa associated lymphoid tissue lymphoma. Clinicopathological study and evaluation of the prognostic factors in 143 patients. Ann Oncol 1995;6:355–362.

    PubMed  CAS  Google Scholar 

  10. Ruskone-Fourmestraux A, et al. Primary digestive tract lymphoma. A prospective multicenter study of 91 patients. Gastroenterology 1993;105:1662–1671.

    PubMed  CAS  Google Scholar 

  11. Rohatainer A, et al. Report on a workshop convened to discuss the pathological and staging classification of gastrointestinal lymphoma. Ann Oncol 1994;5:397–400.

    Google Scholar 

  12. Wotherspoon AC, et al. Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori. Lancet 1993;342:575–577.

    Article  PubMed  CAS  Google Scholar 

  13. Bayerdorffer E, et al. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue after cure of H. pylori infection. Lancet 1995;345:1591–1594.

    Article  PubMed  CAS  Google Scholar 

  14. Caletti G, et al. The importance of endoscopic ultrasonography in the management of low-grade gastric mucosa-associated lymphoid tissue lymphoma. Alimen Pharmacol Ther 2002;16:1715–1722.

    Article  CAS  Google Scholar 

  15. Cupie-Bergman C, et al. Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma. Gut 2003;52:1656 (Letter).

    Article  Google Scholar 

  16. Raderer M, et al. Importance of extensive staging in patients with mucossa associated lymphoid tissue (MALT) type lymphoma. Br J Cancer 2000;83:454–457.

    Article  PubMed  CAS  Google Scholar 

  17. Ruskone-Fourmestraux A, et al. Predictive factors for regression of gastric MALT lymphoma after anti-Helicobacter pylori. Gut 2001;48:297–303.

    Article  PubMed  CAS  Google Scholar 

  18. Gobi PG, et al. The use of surgery on the treatment of gastrointestinal lymphoma other than low-grade MALT lymphoma. Haematologica 2000;85:372–380.

    Google Scholar 

  19. Tsang RW, et al. Localizad mucossa associated lymphoid tissue lymphoma treated with radiation therapy has excellent clinical outcome. J Clin Oncol 2003;21:4157–4124.

    Article  PubMed  Google Scholar 

  20. Schechter NR, Yahalom J. Low-grade MALT lymphoma of the stomach. A review of treatment options. Int J Radiat Oncol Biol Phys 2000;46:1093–1103.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Oncology Research Unit, National Medical Center, IMSS, México, D.F., Mexico

    Agustin Avilés MD

  2. Department of Hematology, National Medical Center, IMSS, México, D.F., Mexico

    María Jesús Nambo, Natividad Neri, Alejandra Talavera & Sergio Cleto

Authors
  1. Agustin Avilés MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. María Jesús Nambo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Natividad Neri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Alejandra Talavera
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sergio Cleto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Agustin Avilés MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Avilés, A., Nambo, M.J., Neri, N. et al. Mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach. Med Oncol 22, 57–62 (2005). https://doi.org/10.1385/MO:22:1:057

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1385/MO:22:1:057

Key Words

Search

Navigation