Skip to main content
Log in

A case of fatal arsenic poisoning

  • Case Report
  • Published:
Forensic Toxicology Aims and scope Submit manuscript

Abstract

We describe a case of poisoning by arsenic trioxide of a young man found dead at home. There were no obvious external signs of arsenic poisoning; but we observed marked endocardial hemorrhages, hepatomegaly, diffuse gastric mucosal hemorrhages, and slight brain edema at autopsy. The Reinsch test for the stomach contents and liver homogenate was positive for arsenic. Wavelength-dispersive X-ray fluorescence spectrometry combined with the Reinsch test showed that fatal levels of arsenic were present in blood and tissues. The cause of death was diagnosed as circulatory collapse caused by arsenic trioxide.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. National Research Institute of Police Science (2001–2005) Annual case reports of drug and toxic poisoning in Japan (in Japanese). Nos. 43–47

  2. Goyer RA (1996) Toxic effects of metals. In: Klaassen CD (ed) Casarett and Doull’s toxicology: the basic science of poisons, 5th edn. McGraw-Hill, New York, pp 691–736

    Google Scholar 

  3. DiMaio DJ, DiMaio VJM (1993) Forensic pathology. CRC, Boca Raton, pp 439–487

    Google Scholar 

  4. Dueñas-Laita A, Pérez-Miranda M, González-López MA, Martín-Escudero JC, Ruiz-Mambrilla M, Blanco-Varela J (2005) Acute arsenic poisoning. Lancet 365:1982

    Article  PubMed  Google Scholar 

  5. Curry AS (1988) Poison detection in human organs, 4th edn. Thomas, Springfield, pp 83–113

    Google Scholar 

  6. Moriya F, Ishizu H (1994) Can microorganisms produce alcohol in body cavities of a living person? A case report. J Forensic Sci 39:883–888

    PubMed  CAS  Google Scholar 

  7. Moriya F, Hashimoto Y (1998) Medicolegal implications of drugs and chemicals detected in intracranial hematomas. J Forensic Sci 43:980–984

    PubMed  CAS  Google Scholar 

  8. Ozo Y, Yoshizawa M, Murata A, Shimazaki S, Kajiwara M, Takagi T, Sato Y (2004) Simple quantitation of arsenic by energy dispersive fluorescence X-ray spectrometer using Reinsch’s test (in Japanese with English abstract). Jpn J Toxicol 17:359–364

    CAS  Google Scholar 

  9. Suzuki S, Suzuki Y (2005) Arsenic compounds and other organic poisons. In: Suzuki O, Watanabe K (eds) Drugs and poisons in humans: a handbook of practical analysis. Springer, Berlin Heidelberg New York, pp 637–647

    Chapter  Google Scholar 

  10. Baselt RC (2002) Disposition of toxic drugs and chemicals in man, 6th edn. Biomedical, Foster City, pp 79–82

    Google Scholar 

  11. Sanz P, Corbella J, Nogué S, Munné P, Rodriguez-Pazos M (1989) Rhabdomyolysis in fatal arsenic trioxide poisoning. J Am Med Assoc 262:3271

    Article  CAS  Google Scholar 

  12. Benramdane L, Accominotti M, Fanton L, Malicier D, Vallon J-J (1999) Arsenic speciation in human organs following fatal arsenic trioxide poisoning: a case report. Clin Chem 45:301–306

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fumio Moriya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Moriya, F., Furumiya, J. & Hashimoto, Y. A case of fatal arsenic poisoning. Forensic Toxicol 24, 88–91 (2006). https://doi.org/10.1007/s11419-006-0015-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11419-006-0015-1

Keywords

Navigation