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The effect of topical sodium diclofenac on macular thickness in diabetic eyes after phacoemulsification: a randomized controlled trial

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Abstract

To evaluate the efficacy of prophylactic administration of the topical diclofenac 0.1 % on macular thickness in diabetic patients following phacoemulsification and intraocular lens implantation surgery. In a Randomized double-masked clinical trial, 108 eyes of 108 diabetic patients underwent phacoemulsification and intraocular lens implantation surgery were enrolled. Fifty four eyes received the conventional postoperative care with steroid drop, whereas the other group (54 eyes) was given a preoperative diclofenac drop four times daily in addition to steroid drop and continued 6 weeks after surgery. All patients were evaluated by optical coherence tomography (OCT) preoperatively and days 1, 30, and 90. The outcome measures including best-corrected visual acuity and OCT findings were compared in and between both groups. Mean CMT changed from 239 ± 16 and 235 ± 17 at baseline to 249 ± 15 and 254 ± 28 at 3 months in the case and control groups, respectively(p = 0.003). Mean total volume of macula changed from 7.61 ± 0.22 and 7.56 ± 0.3 at baseline to 7.64 ± 0.22 and 7.65 ± 0.31 at 3 months in the case and control groups, respectively (p = 0.820). In comparison to the quadrants thicknesses and mean of them between groups did not reach the significant level. This study showed that there is a beneficial effect of topical diclofenac for prevention of macular thickness increasing following phacoemulsification in diabetic patients.

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Authors and Affiliations

  1. Ophthalmic Research Center, Department of Ophthalmology, Imam Hossein Medical Center, Shahid Beheshti Medical Sciences, Shahid Madani Ave, Tehran, Iran

    Morteza Entezari, Alireza Ramezani & Homayon Nikkhah

  2. Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran

    Mehdi Yaseri

Authors
  1. Morteza Entezari
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  2. Alireza Ramezani
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  3. Homayon Nikkhah
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  4. Mehdi Yaseri
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Correspondence to Morteza Entezari.

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None of the authors have any financial/conflicting interests to disclose.

Additional information

Trial registration: clinical trials.gov identifier: NCT02306031.

The work was carried out by Ophthalmic Research Centre Shahid Beheshti Medical University.

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Entezari, M., Ramezani, A., Nikkhah, H. et al. The effect of topical sodium diclofenac on macular thickness in diabetic eyes after phacoemulsification: a randomized controlled trial. Int Ophthalmol 37, 13–18 (2017). https://doi.org/10.1007/s10792-016-0209-4

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  • DOI: https://doi.org/10.1007/s10792-016-0209-4

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