Skip to main content
SpringerLink
Log in

T lymphocyte subsets and Th1/Th2 balance after laparoscopy-assisted distal gastrectomy

  • Original article
  • Published:
Surgical Endoscopy And Other Interventional Techniques Aims and scope Submit manuscript

Abstract

Background: Laparoscopic surgery provides for a less invasive procedure than open surgery in patients with gastric cancer, but the immune responses after laparoscopic surgery for early gastric cancer remain unknown. Methods: Peripheral blood mononuclear cells from 20 patients with early gastric cancer who underwent laparoscopy-assisted distal gastrectomy (LADG) or open distal gastrectomy (ODG) were obtained; the cell surface molecules and intracellular cytokines (IFN-gamma and IL-4) were measured by flow cytometry. Results: The populations of T lymphocytes after LADG, including CD3-, 4-, 8-, 57-, and HLA-DR-positive lymphocytes, showed patterns similar to those after ODG. The production of IFN-gamma as Th1 cell function decreased significantly on the third postoperative day after ODG but increased after LADG. The production of IL-4, representing Th2 cell function, increased postoperatively after ODG but not after LADG. Conclusions: When compared with ODG, LADG contributes to the preservation of postsurgical Th1 cell-mediated immune function.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Y Adachi N Shiraishi A Shiromizu T Bandoh M Aramaki S Kitano (2000) ArticleTitleLaparoscopy-assisted Billroth I gastrectomy compared with conventional open gastrectomy. Arch Surg 135 806–810 Occurrence Handle10.1001/archsurg.135.7.806 Occurrence Handle1:STN:280:DC%2BD3czltlaksg%3D%3D Occurrence Handle10896374

    Article  CAS  PubMed  Google Scholar 

  2. JDF Allendorf M Bessler RL Whelan M Trokel DA Laird MB Terry et al. (1997) ArticleTitlePostoperative immune function varies inversely with the degree of surgical trauma in a murine model. Surg Endosc 11 427–430

    Google Scholar 

  3. R Berguer CN Bravo M Bowyer C Egan T Knolmayer D Ferrick (1999) ArticleTitleMajor surgery suppresses maximal production of helper T-cell type 1 cytokines without potentiating the release of helper T-cell type 2 cytokines. Arch Surg 134 540–544 Occurrence Handle10.1001/archsurg.134.5.540 Occurrence Handle1:STN:280:DyaK1M3lsFSjtA%3D%3D

    Article  CAS  Google Scholar 

  4. IB Brune W Wilke T Hensler B Holzmann JR Siewert (1999) ArticleTitleDownregulation of T helper type 1 immune response and altered pro-inflammatory and anti-inflammatory T cell cytokine balance following conventional but not laparoscopic surgery. Am J Surg 177 55–60 Occurrence Handle10.1016/S0002-9610(98)00299-2 Occurrence Handle1:STN:280:DyaK1M7lsV2isQ%3D%3D Occurrence Handle10037309

    Article  CAS  PubMed  Google Scholar 

  5. NV Christou JL Meakins J Gordon J Yee M Hassan-Zahraee CW Nohr HM Shizgal (1995) ArticleTitleThe delayed hypersensitivity response and host resistance in surgical patients. Ann Surg 222 534–548 Occurrence Handle1:STN:280:BymD38rht1A%3D Occurrence Handle7574933

    CAS  PubMed  Google Scholar 

  6. ML Da Costa HP Redmond DJ Bouchier-Hayes (1998) ArticleTitleThe effect of laparotomy and laparoscopy on the establishment of spontaneous tumor metastases. Surgery 124 516–525 Occurrence Handle10.1067/msy.1998.89410 Occurrence Handle1:STN:280:DyaK1cvgvVWisw%3D%3D Occurrence Handle9736904

    Article  CAS  PubMed  Google Scholar 

  7. D Decker M Schondorf F Bidlingmaier A Hirner AA von Ruecker (1996) ArticleTitleSurgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery 119 316–325 Occurrence Handle1:STN:280:BymB3c3lsFY%3D Occurrence Handle8619187

    CAS  PubMed  Google Scholar 

  8. AMM Eggermont EP Steller PH Sugarbaker (1987) ArticleTitleLaparotomy enhances intraperitoneal tumor growth and abrogates the antitumor effects of interleukin-2 and lymphokine-activated killer cells. Surgery 102 71–78 Occurrence Handle1:STN:280:BiiB3svptVI%3D Occurrence Handle3495896

    CAS  PubMed  Google Scholar 

  9. E Faist TS Kupper CC Baker IH Chaudry J Dwyer AE Baue (1986) ArticleTitleDepression of cellular immunity after major injury. Arch Surg 121 1000–1005 Occurrence Handle1:STN:280:BimB1MvpvF0%3D Occurrence Handle3741094

    CAS  PubMed  Google Scholar 

  10. CA Gitzelmann M Mendoza-Sagaon MA Talamini SA Ahmad W Pegoli Jr CN Paidas (1999) ArticleTitleCell-mediated immune response is better preserved by laparoscopy than laparotomy. Surgery 126 65–71

    Google Scholar 

  11. F Glaser GA Sannwald HJ Buhr C Kuntz H Mayer F Klee C Herfarth (1995) ArticleTitleGeneral stress response to conventional and laparoscopic cholecystectomy. Ann Surg 221 372–380 Occurrence Handle1:STN:280:ByqB2czns1Q%3D Occurrence Handle7726672

    CAS  PubMed  Google Scholar 

  12. JP Griffith NJ Everitt F Lancaster A Boylston SJ Richards CS Scott EA Benson HM Sue-Ling MJ McMahon (1995) ArticleTitleInfluence of laparoscopic and conventional cholecystectomy upon cell-mediated immunity. Br J Surg 82 677–680

    Google Scholar 

  13. AJ Karayiannakis GG Makri A Mantzioka D Karousos G Karatzas (1997) ArticleTitleSystemic stress response after laparoscopic or open cholecystectomy: a randomized trial. Br J Surg 84 467–471 Occurrence Handle1:STN:280:ByiB28jls1A%3D Occurrence Handle9112894

    CAS  PubMed  Google Scholar 

  14. S Kitano Y Iso M Moriyama K Sugimachi (1994) ArticleTitleLaparoscopy-assisted Billroth I gastrectomy. Surg Laparosc Endosc 4 146–148 Occurrence Handle1:STN:280:ByuB3snjtlw%3D Occurrence Handle8180768

    CAS  PubMed  Google Scholar 

  15. S Kitano N Shiraishi K Fujii K Yasuda M Inomata Y Adachi (2002) ArticleTitleA randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: An interim report. Surgery 131 IssueIDsupplement 306–311 Occurrence Handle10.1067/msy.2002.120115

    Article  Google Scholar 

  16. T Kloosterman ME von-Blomberg P Borgstein MA Cuesta RJ Scheper S Meijer (1994) ArticleTitleUnimpaired immune functions after laparoscopic cholecystectomy. Surgery 115 424–428 Occurrence Handle1:STN:280:ByuB3MfnvVY%3D Occurrence Handle8165532

    CAS  PubMed  Google Scholar 

  17. JT Liang MJ Shieh CN Chen YM Cheng KJ Chang SM Wang (2002) ArticleTitleProspective evaluation of laparoscopy-assisted colectomy versus laparotomy with resection for management of complex polyps of the sigmoid colon. World J Surg 26 377–383 Occurrence Handle10.1007/s00268-001-0235-9 Occurrence Handle11865378

    Article  PubMed  Google Scholar 

  18. AJ McMahon IT Russell G Ramsay G Sunderland JN Baxter JR Anderson D Galloway PJ O’Dwyer (1994) ArticleTitleLaparoscopic and minilaparotomy cholecystectomy: A randomized trial comparing postoperative pain and pulmonary function. Surgery 115 533–539 Occurrence Handle1:STN:280:ByuB3szkvVE%3D Occurrence Handle8178250

    CAS  PubMed  Google Scholar 

  19. K Ogawa M Hirai T Katsube M Murayama K Hamaguchi T Shimakawa Y Naritake T Hosokawa T Kajiwara (2000) ArticleTitleSuppression of cellular immunity by surgical stress. Surgery 127 329–336 Occurrence Handle10.1067/msy.2000.103498 Occurrence Handle1:STN:280:DC%2BD3c7otV2guw%3D%3D Occurrence Handle10715990

    Article  CAS  PubMed  Google Scholar 

  20. P Openshaw EE Murphy NA Hosken V Maino K Davis K Murphy A O’Garra (1995) ArticleTitleHeterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 182 1357–1367 Occurrence Handle1:CAS:528:DyaK2MXovFWqsrw%3D Occurrence Handle7595206

    CAS  PubMed  Google Scholar 

  21. J Ordemann CA Jacobi W Schwenk R Stosslein JM Muller (2001) ArticleTitleCellular and humoral inflammatory response after laparoscopic and conventional colorectal resections. Surg Endosc 15 600–608

    Google Scholar 

  22. N Shiraishi Y Adachi S Kitano T Bandoh T Katsuta A Morimoto (1999) ArticleTitleIndication for and outcome of laparoscopy- assisted Billroth I gastrectomy. Br J Surg 86 541–544 Occurrence Handle10.1046/j.1365-2168.1999.01083.x Occurrence Handle1:STN:280:DyaK1M3jtlOkug%3D%3D Occurrence Handle10215833

    Article  CAS  PubMed  Google Scholar 

  23. A Shiromizu T Suematsu K Yamaguchi N Shiraishi Y Adachi S Kitano (2000) ArticleTitleEffect of laparotomy and laparoscopy on the establishment of lung metastasis in a murine model. Surgery 128 799–805 Occurrence Handle1:STN:280:DC%2BD3M%2FjsFGktw%3D%3D Occurrence Handle11056443

    CAS  PubMed  Google Scholar 

  24. T Tabata S Hazama S Yoshino M Oka (1999) ArticleTitleTh2 subset dominance among peripheral blood T lymphocytes in patients with digestive cancers. Am J Surg 177 203–208 Occurrence Handle10.1016/S0002-9610(99)00004-5 Occurrence Handle1:STN:280:DyaK1M3jsFalsw%3D%3D Occurrence Handle10219855

    Article  CAS  PubMed  Google Scholar 

  25. CH Wakefield PD Carey S Foulds JRT Monson PJ Guillou (1993) ArticleTitleChanges in major histocompatibility complex class II expression in monocytes and T cells of patients developing infection after surgery. Br J Surg 80 205–209 Occurrence Handle1:STN:280:ByyC1cvotl0%3D Occurrence Handle8443652

    CAS  PubMed  Google Scholar 

  26. CBJ Walker DM Bruce SD Heys DB Gough NR Binnie O Eremin (1999) ArticleTitleMinimal moduration of lymphocyte and natural killer cell subsets following minimal access surgery. Am J Surg 177 48–54 Occurrence Handle10.1016/S0002-9610(98)00290-6 Occurrence Handle1:STN:280:DyaK1M7lsV2isA%3D%3D Occurrence Handle10037308

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery I, Oita Medical University, Oita 879-5593, Japan

    K. Fujii, K. Sonoda, K. Izumi, N. Shiraishi, Y. Adachi & S. Kitano

Authors
  1. K. Fujii
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Sonoda
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Izumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. Shiraishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Y. Adachi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Kitano
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Fujii.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fujii, K., Sonoda, K., Izumi, K. et al. T lymphocyte subsets and Th1/Th2 balance after laparoscopy-assisted distal gastrectomy . Surg Endosc 17, 1440–1444 (2003). https://doi.org/10.1007/s00464-002-9149-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00464-002-9149-3

Keywords

Search

Navigation