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The Value of Neutrophil:Lymphocyte Ratio and Platelet:Lymphocyte Ratio in Predicting Clinical Severity in Children with Carbon Monoxide Poisoning

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Abstract

Objective

To compare the values of neutrophil:lymphocyte ratio (NLR), platelet:lymphocyte ratio (PLR), and mean platelet volume (MPV) with carboxyhemoglobin (COHb) and lactate levels in children with acute CO intoxication.

Methods

In this retrospective study, the patients were divided into two groups: mild-to-moderate carbon monoxide poisoning (COP) (COHb 10%–20%) and severe COP (COHb > 20%) according to the COHb levels in the application. All patients were compared in terms of NLR, PLR, and MPV parameters according to the severity of poisoning and the high lactate levels (≥ 2.2 mmol/L).

Results

A total of 261 children with COP were included in the study. The number of patients with mild-to-moderate COP was 183 (70.1%), and the number of patients with severe COP was 78 (29.9%). NLR [2.57 (3.27), 1.65 (1.93), (p = 0.001)] and PLR [123.0 (88.24), 92.8 (54.1), (p = 0.001)] values of mild-to-moderate COP were statistically significantly lower than the severe COP group. In the group with high lactate level, PLR values were significantly lower [120.1 (71.9), 100.2 (85.4), (p = 0.017)]. NLR and PLR values were found to be predictive of severe COP.

Conclusion

NLR and PLR can be used for detection of clinical severity in patients with COP. PLR can be used in conjunction with lactate levels to detect tissue-level exposure in patients with COP.

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Data Availability

The datasets used and/or analyzed in the current study are available and can be obtained from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Pediatrics, Konya Education and Research Hospital, University of Health Sciences, Konya, Turkey

    Zafer Bağcı

  2. Department of Undersea and Hyperbaric Medicine, Necmettin Erbakan University Meram Tıp Faculty, Konya, Turkey

    Abdullah Arslan

  3. Department of Pediatric Cardiology, Konya Education and Research Hospital, University of Health Sciences, Konya, Turkey

    Derya Arslan

Authors
  1. Zafer Bağcı
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  2. Abdullah Arslan
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  3. Derya Arslan
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Contributions

ZB conceptualized and designed the study, collected data, drafted the initial manuscript, and reviewed and revised the manuscript; AA supervised participant enrollment and data acquisition, and participated in data interpretation; DA participated in data interpretation and conducted the analysis. DA would act as guarantor for this paper.

Corresponding author

Correspondence to Zafer Bağcı.

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Ethics Approval and Consent to Participate

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Konya Education and Research Hospital, University of Health Sciences Turkey (Date: 05.04.2018 / No: 14–18).

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None.

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Bağcı, Z., Arslan, A. & Arslan, D. The Value of Neutrophil:Lymphocyte Ratio and Platelet:Lymphocyte Ratio in Predicting Clinical Severity in Children with Carbon Monoxide Poisoning. Indian J Pediatr 88, 1121–1126 (2021). https://doi.org/10.1007/s12098-021-03704-w

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  • DOI: https://doi.org/10.1007/s12098-021-03704-w

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