Abstract
Oncofertility is an interdisciplinary field in which providers of oncology and reproductive health care provide patients with options for fertility after cancer treatment. Infertility following cancer treatment occurs for various reasons including the need for removal of reproductive organs as well as the effects of chemotherapy and radiation on gametes and reproductive hormones. Unfortunately, few patients have comprehensive counseling on fertility preservation options prior to undergoing treatment (Schover et al., Cancer 86(4):697–709, 1999). This chapter explains the options for maintenance of fertility including oophoropexy/ovarian transposition, conservative surgical and medical management of gynecologic cancers, embryo cryopreservation via in vitro fertilization, oocyte cryopreservation, use of donor oocytes and donor embryos, gestational surrogacy, ovarian cortex cryopreservation and transplantation, in vitro maturation, ovarian suppression, uterine transplantation, and the potential for generation of gametes from somatic cells.
My health care team had everything coordinated for me like I was royalty. I had the breast cancer surgery in early March, and two weeks later I was starting my treatment for egg retrieval. I started my chemotherapy, as planned, the next month. I thought doing the egg retrieval right after I finished surgery was going to be too intense, but I was so happy to be doing something that was going to take me one step closer to having the baby I always dreamed of. During the dark days of chemo, I often thought about my frozen eggs and how better things lay ahead for me. I am so thankful that I was in a place that knew how to coordinate all this for me. I read horror stories on line about women who weren’t told about infertility or weren’t given options or were told it would delay their treatment and there wasn’t time. I can’t say I’m glad I got cancer, but I am elated with the coordination I had for all aspects of my care.
Courtney, Adult Cancer Patient
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Abbreviations
- AMH:
-
anti-Mullerian hormone
- ART:
-
assisted reproductive technologies
- ASRM:
-
American Society for Reproductive Medicine
- cGy:
-
centigray
- FSH:
-
follicle stimulating hormone
- GnRH:
-
gonadotropin-releasing hormone
- Gy:
-
Gray
- hCG:
-
human chorionic gonadotropin
- IVF:
-
in vitro fertilization
- IVM:
-
in vitro maturation
- OHSS:
-
ovarian hyperstimulation syndrome
- PGD:
-
preimplantation genetic diagnosis
- SART:
-
The Society for Assisted Reproductive Technologies
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Bailey, A.P., Ginsburg, E.S. (2012). Fertility Preservation Options for Females. In: Quinn, G., Vadaparampil, S. (eds) Reproductive Health and Cancer in Adolescents and Young Adults. Advances in Experimental Medicine and Biology, vol 732. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2492-1_2
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