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Zusammenfassung

Antipsychotika sind eine chemisch heterogene Gruppe von Pharmaka mit antipsychotischem Wirksamkeitsschwerpunkt und unterschiedlichem NW-Profil. Der häufig synonym verwendete Begriff »Neuroleptikum« wird international immer mehr durch den Begriff Antipsychotikum ersetzt. Dieser weist auf die klinisch bedeutsame therapeutische Wirkung bei psychotischen Störungen, insbesondere schizophrenen Psychosen, hin.

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Literatur

  • Addington DE, Mohamed S, Rosenheck RA et al (2011) Impact of second-generation antipsychot- ics and perphenazine on depressive symptoms in a randomized trial of treatment for chronic schizophrenia. J Clin Psychiatry 72(1): 75–80

    Article  PubMed  CAS  Google Scholar 

  • Citrome L (2011) A systematic review of meta-analyses of the efficacy of oral atypical antipsychot- ics for the treatment of adult patients with schizophrenia. Expert Opin Pharmacother 13(11): 1545–1573

    Article  PubMed  Google Scholar 

  • Correll CU, Rummel-Kluge C, Corves C et al (2009) Antipsychotic combinations vs monotherapy in schizophrenia: a meta-analysis of randomized controlled trials. Schizophr Bull 35(2): 443–457

    Article  Google Scholar 

  • DGPPN (Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde) (Hrsg) (2006) Behandlungsleitlinie Schizophrenie. Reihe: S3 Praxisleitlinien in Psychiatrie und Psychotherapie, Bd 1. Springer, Berlin Heidelberg New York

    Google Scholar 

  • DGPPN, BÄK, KBV, AWMF, AkdÄ, BPtK, BApK, DAGSHG, DEGAM, DGPM, DGPs, DGRW (2012) S3-Leitlinie/Nationale Versorgungsleitlinie Unipolare Depression; Langfassung Version 1.3. Januar, basierend auf der Fassung von November 2009. AWMF-Register-Nr. nvl-005

    Google Scholar 

  • Dickerson FB, Lehman AF (2011) Evidence-based psychotherapy for schizophrenia: 2011 update.J Nerv Ment Dis 199(8): 520–526

    Article  PubMed  Google Scholar 

  • Gaebel W, Riesbeck M, Wölwer W et al; German Study Group on First-Episode Schizophrenia (2011) Relapse prevention in first-episode schizophrenia - maintenance vs intermittent drug treat- ment with prodrome-based early intervention: results of a randomized controlled trial with- in the German Research Network on Schizophrenia. J Clin Psychiatry 72(2): 205–218

    Article  Google Scholar 

  • Ho BC, Andreasen NC, Ziebell S et al (2011) Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 68(2): 128–137

    Article  Google Scholar 

  • Hui WK, Mitchell LB, Kavanagh KM et al (1990) Melperone: electrophysiologic and antiarrhythmic activity in humans. J Cardiovasc Pharmacol 15: 144–149

    Article  PubMed  CAS  Google Scholar 

  • Kales HC, Kim HM, Zivin K et al (2012) Risk of mortality among individual antipsychotics in patients with dementia. Am J Psychiatry 169(1): 71–79

    PubMed  Google Scholar 

  • Kelly TM, Daley DC, Douaihy AB (2012) Treatment of substance abusing patients with comorbid psychiatric disorders. Addict Behav 37(1): 11–24

    Article  PubMed  Google Scholar 

  • Kinon BJ, Chen L, Ascher-Svanum H et al (2010) Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophrenia. Neuropsychop- harmacology 35: 581–590

    Google Scholar 

  • Kishimoto T, Agarwal V, Kishi T et al (2011) Relapse prevention in schizophrenia: a systematic review and meta-analysis of second-generation antipsychotics versus first-generation antipsy- chotics. Mol Psychiatry, Epub ahead of print

    Google Scholar 

  • Klosterkötter J, Schultze-Lutter F, Bechdolf A, Ruhrmann S (2011) Prediction and prevention of schizophrenia: what has been achieved and where to go next? World Psychiatry 10(3): 165–174

    PubMed  Google Scholar 

  • Leucht S, Corves C, Arbter D et al (2009) Second-generation versus first-generation antipsychotic drugs for schizophrenia: a meta-analysis. Lancet 373: 31–41

    Article  PubMed  CAS  Google Scholar 

  • Leucht C, Heres S, Kane JM et al (2011) Oral versus depot antipsychotic drugs for schizophrenia - a critical systematic review and meta-analysis of randomised long-term trials. Schizophr Res. 127(1-3): 83–92

    Article  PubMed  Google Scholar 

  • Maayan L, Vakhrusheva J, Correll CU (2010) Effectiveness of medications used to attenuate antip- sychotic-related weight gain and metabolic abnormalities: a systematic review and meta- analysis. Neuropsychopharmacology 35(7): 1520–1530

    Article  Google Scholar 

  • Naber D, Lambert M (2009) The CATIE and CUtLASS studies in schizophrenia: results and implications for clinicians. CNS Drugs 23(8): 649–659

    PubMed  Google Scholar 

  • Porcelli S, Balzarro B, Serretti A (2012) Clozapine resistance: augmentation strategies. Eur Neuropsychopharmacol 22(3): 165–182

    Article  PubMed  CAS  Google Scholar 

  • Ray WA, Chung CP, Murray KT et al (2009) Atypical antipsychotic drugs and the risk of sudden cardiac death. N Engl J Med 360(3): 225–235

    Article  PubMed  CAS  Google Scholar 

  • Röder V, Mueller DR, Schmidt SJ (2011) Effectiveness of integrated psychological therapy (IPT) for schizophrenia patients: a research update. Schizophr Bull 37(Suppl 2): S71–79

    Article  PubMed  Google Scholar 

  • Rummel-Kluge C, Komossa K, Schwarz S et al (2010) Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis. Schizophr Res 123(2-3): 225–233

    Article  PubMed  Google Scholar 

  • Rummel-Kluge C, Komossa K, Schwarz S et al (2012) Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons. Schizophr Bull 38(1): 167–177

    Article  PubMed  Google Scholar 

  • Steinert T, Baier H, Fröscher W, Jandl M (2011) Epileptische Anfälle unter der Behandlung mit Antidepressiva und Neuroleptika. Fortschr Neurol Psychiatr 79(3): 138–143

    Article  PubMed  CAS  Google Scholar 

  • Tiihonen J, Haukka J, Taylor M et al (2011) A nationwide cohort study of oral and depot anti- psychotics after first hospitalization for schizophrenia. Am J Psychiatry 168(6): 603–609

    Article  PubMed  Google Scholar 

  • Tiihonen J, Suokas JT, Suvisaari JM et al (2012) Polypharmacy with antipsychotics, antidepressants, or benzodiazepines and mortality in schizophrenia. Arch Gen Psychiatry 69: 476–483

    Article  PubMed  CAS  Google Scholar 

  • Wenzel-Seifert K, Wittmann M, Haen E (2011) QTc prolongation by psychotropic drugs and the risk of Torsades de Pointes. Dtsch Arztebl Int 108(41): 687–693

    PubMed  Google Scholar 

  • Wolter DK (2009) Risiken von Antipsychotika im Alter, speziell bei Demenzen. Z Gerontopsychol -psychiatrie 22(1): 17–56

    Article  Google Scholar 

  • Zhang R, Dong L, Shao F et al (2011) Antipsychotics and venous thromboembolism risk: a meta- analysis. Pharmacopsychiatry 44(5): 183–188

    Article  PubMed  CAS  Google Scholar 

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Benkert, O., Hippius, H. (2013). Antipsychotika. In: Kompendium der Psychiatrischen Pharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-29810-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-29810-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-29809-7

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