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Effects of Nucleoside Transport Inhibitors and Adenine/Ribose on ATP Concentration and Adenosine Production in Cardiac Myocytes

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Purine and Pyrimidine Metabolism in Man IX

Abstract

Adenosine is an important catabolite of adenine nucleotides with potent coronary vasodilatory, antiplatelet, antileukocyte and antiarrhythmic properties.1–4 The clinical relevance of these actions of adenosine make it an important therapeutic and diagnostic tool.

A version of this paper was prepared for presentation at the Rutgers University 13th Annual Western Conference on Competitive Challenges in Network Industries, Monterey, CA, July 5–7, 2000. We would like to than our discussants, Fred Curry, Jutta Shaw and Yasugi Otsuka for helpful comments. In addition, we benefitted from discussions with Eric Ackerman, Carl Danner, Ahmad Faruqui and Dennis Weisman. Finally we would like to thank EPRI for providing support in a related area of research.

The erratum of this chapter is available at http://dx.doi.org/10.1007/978-1-4615-5381-6_165

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Kalsi, K.K., Smolenski, R.T., Yacoub, M.H. (1998). Effects of Nucleoside Transport Inhibitors and Adenine/Ribose on ATP Concentration and Adenosine Production in Cardiac Myocytes. In: Griesmacher, A., Müller, M.M., Chiba, P. (eds) Purine and Pyrimidine Metabolism in Man IX. Advances in Experimental Medicine and Biology, vol 431. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5381-6_18

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  • DOI: https://doi.org/10.1007/978-1-4615-5381-6_18

  • Publisher Name: Springer, Boston, MA

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