Skip to main content

Clinical Practice Guidelines for the Use of Erythroid-Stimulating Agents: ASCO, EORTC, NCCN

  • Chapter
  • First Online:
Hematopoietic Growth Factors in Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 157))

Abstract

Three organizations spent a great amount of time, effort, and money writing clinical practice guidelines for the use of erythroid-stimulating agents (ESAs). The American Society of Hematology and American Society of Clinical Oncology (ASH/ASCO) panel was convened by these respective professional societies in the United States and a guideline was written in 2002 [1] and an update was published January 1, 2008 (called the 2007 update) [2]. The European equivalent professional society, European Organization for Research and Treatment of Cancer (EORTC), wrote their original guideline in 2004 and updated their ESA guideline in January 2007 [3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Rizzo JD, Lichtin AE, Woolf SH, et al. Use of epoetin in patients with cancer: evidence based clinical practice guidelines of the American Society of Clinical Oncology and the American Society of Hematology. J Clin Oncol. 2002;20:4083–107.

    Article  CAS  PubMed  Google Scholar 

  2. Rizzo JD, Somerfield MR, Hagerty KL, Seidenfeld J, Bohlius J, Bennett CL, Cella DF, Djulbegovic B, Goode MJ, Jakubowski AA, Rarick MU, Regan DH, Lichtin AE. Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Clinical Oncology/American Society of Hematology clinical practice guideline update. J Clin Oncol. 2008;26(1):132–49.

    Article  CAS  PubMed  Google Scholar 

  3. Bokemeyer C, Aapro MS, Courdi A, Foubert J, Link H, Osterborg A, Repetto L, Sonbeyran P. European Organization for Research and Treatment of Cancer [EORTC] guidelines for the use of erythropoietin proteins in anaemic patients with cancer; 2006 update. Eur J Cancer. 2007;43(2):258–70. [E pub 2006 Dec 19].

    Article  CAS  PubMed  Google Scholar 

  4. Rodgers GM, Becker PS, Bennett CL, Cella D, Chavan-klian A, Chesney C, Cleeland C, Coccia PF, Djubegovic B, Garet J, Gilreath JA, Kraut E, Lin WC, Matulovis U, Millensor M, Reinke D, Rosenthal J, Sabbatini P, Schwartz RN, Stein R, Vij R. Cancer and chemotherapy induced anemia [clinical practice guidelines in oncology]. J Natl Compr Canc Netw. 2008;6(6):536–64.

    CAS  PubMed  Google Scholar 

  5. Minton O, Stone P, Richardson A, et al. Drug therapy for the management of cancer related fatigue. Cochrane Database Syst Rev. 2008:CD006704.

    Google Scholar 

  6. Cella D, Eton DT, Lai J-S, et al. Combining anchor and distribution based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy anemia and fatigue scales. J Pain Symptom Manage. 2002;24:547–61.

    Article  PubMed  Google Scholar 

  7. Cella D, Dobrez D, Glaspy J. Control of cancer-related anemia with erythropoietic agents: a review of evidence for improved quality of live and clinical outcomes. Ann Oncol. 2003;14:511–19.

    Article  CAS  PubMed  Google Scholar 

  8. Fallowfield L, Gagnon D, Cella D, et al. Multivariate regression analyses of data from a randomized, double-blind, placebo-controlled study confirmed quality of life benefit of epoetin alfa in patients receiving non-platinum chemotherapy. Br J Cancer. 2002;87:1341–53.

    Article  CAS  PubMed  Google Scholar 

  9. Hagerty K. Continued regulatory actions affecting the use of erythropoiesis-stimulating agents. J Oncol Pract. 2008;4(6):267–70.

    Article  PubMed  Google Scholar 

  10. Glaspy JA. Erythropoiesis-stimulating agents in oncology. J Natl Compr Canc Netw. 2008;6(6):565–84.

    CAS  PubMed  Google Scholar 

  11. European Medicines Agency Document. Doc Ref EMEA/CHMP/333962/2008, Jun 26 2008.

    Google Scholar 

  12. Bennett CL, Silver SM, Djulbegovic G, et al. Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer associated anemia. J Amer Med Assn. 2008;299(8):914–24.

    Article  CAS  Google Scholar 

  13. Thomas G, Ali S, Hoebers FJ, et al. Phase III trial to evaluate the efficacy of maintaining hemoglobin levels above 12 g/dL with erythropoietin vs. above 10 g/dL without erythropoietin in anemic patients receiving concurrent radiation and cisplatinum for cervical cancer. Gynecol Oncol. 2008;108:317–25.

    Article  CAS  PubMed  Google Scholar 

  14. Bennett CL, Angelotta C, Yarnold PR, et al. Thalidomide and lenolidomide-associated thromboembolism among patients with cancer. J Amer Med Assn. 2006;296:2558–60.

    Article  CAS  Google Scholar 

  15. Auerbach M, Ballard H, Trout JR, et al. Intravenous iron optimizes the response to recombinant human erythropoietin in cancer patients with chemotherapy-related anemia: a multicenter open-label, randomized trial. J Clin Oncol. 2004;22:1301–7.

    Article  CAS  PubMed  Google Scholar 

  16. Henry DH, Dahl NV, Auerbach M, et al. Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist. 2007;12:231–42.

    Article  CAS  PubMed  Google Scholar 

  17. Hedenus M, Birgegard G, Nasman P, et al. Addition of intravenous iron to epoetin beta increases hemoglobin response and decreases epoetin dose requirement in anemic patients with lymphoproliferative malignancies: a randomized multicenter study. Leukemia. 2007;21:627–32.

    CAS  PubMed  Google Scholar 

  18. Bastit L, Vanderbroek A, Altintas S, et al. Randomized, multicenter, controlled trial comparing the efficacy and safety of darbepoetin alfa administered every 3 weeks with or without intravenous iron in patients with chemotherapy-induced anemia. J Clin Oncol. 2008;26(10):1611–18.

    Article  CAS  PubMed  Google Scholar 

  19. Pedrazzoli P, Farris A, Del Prete S, et al. Randomized trial of intravenous iron supplementation in patients with chemotherapy-related anemia without iron deficiency treated with darbepoetin alfa. J Clin Oncol. 2008;26(10):1619–25.

    Article  CAS  PubMed  Google Scholar 

  20. Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anemia undergoing radiotherapy: randomized, double-blind, placebo-controlled trial. Lancet. 2003;362:1255–60.

    Article  CAS  PubMed  Google Scholar 

  21. Leyland-Jones B, Semiglozov V, Pawliki M, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly non anemic patients with metastatic breast cancer receiving first line chemotherapy. A survival study. J Clin Oncol. 2005;23:5960–72.

    Article  CAS  PubMed  Google Scholar 

  22. Wright JR, Ung YC, Julian JA, et al. Randomized double-blind, placebo-controlled trial of erythropoietin in non-small cell lung cancer with disease related anemia. J Clin Oncol. 2007;25:1027–32.

    Article  CAS  PubMed  Google Scholar 

  23. Hedenus M, Adriansson M, San Miguel J, et al. Efficacy and safety of darbepoetin alfa in anemic patients with lymphoproliferative malignancies: a randomized, double-blind, placebo-controlled study. Br J Haematol. 2003;122:394–403.

    Article  CAS  PubMed  Google Scholar 

  24. Overgaard J, Hoff C, San Hansen H. Randomized study of the importance of novel erythropoiesis stimulating protein (Aranesp) for the effect of radiotherapy in patients with primary squamous cell carcinoma of the head and neck (HNSCC): the Danish Head and Neck Cancer Group (DAHANCA 10 [Abstract]). Eur J Cancer Suppl. 2007;5(6):7. Abstract 6LB.

    Article  Google Scholar 

  25. Smith RE Jr, Aapro MS, Ludwig H, et al. Darbepoetin alfa for the treatment of anemia in patients with active cancer not receiving chemotherapy or radiotherapy: results of a phase III, multicenter randomized, double-blind, placebo-controlled study. J Clin Oncol. 2008;26:1040–50.

    Article  CAS  PubMed  Google Scholar 

  26. U.S. Food and Drug Administration. Press release: FDA receives new data on risks of anemia drugs consistent with previous data on tumor growth and death. 3 Jan 2008. Available at http://www.fda.gov/lls/topics/NEWS/2008/NEW01769.html

  27. Anonymous. A randomized double-blind placebo-controlled study with subcutaneous recombinant human erythropoietin in patients with low risk myelodysplastic syndromes: Italian Cooperative Study Group for rHuEpo in Myelodysplastic Syndromes. Br J Haematol. 1998;103:1070–4.

    Article  Google Scholar 

  28. Rothman DJ, McDonald WJ, Berkowitz CD, et al. Professional medical associations and their relationships with industry. JAMA 2009;301(13):1367–72.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Alan E. Lichtin .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Lichtin, A.E. (2010). Clinical Practice Guidelines for the Use of Erythroid-Stimulating Agents: ASCO, EORTC, NCCN. In: Lyman, G., Dale, D. (eds) Hematopoietic Growth Factors in Oncology. Cancer Treatment and Research, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7073-2_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-7073-2_14

  • Published:

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-7072-5

  • Online ISBN: 978-1-4419-7073-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics