The rational application of integrated multidisciplinary therapy of prostate cancer (PC) requires an understanding of the determinants of cancer progression and response to therapy to successfully treat common adult cancers. In the successful examples of therapy application agents (chemotherapy, biologics) and other modalities (radiation, surgery) are applied on the basis of clinical biology during specific intervals in progression. Thus integrating the knowledge of clinical biology with an appreciation for the determinants is central to therapy development.
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Logothetis, C.J. (2008). Strategy for the Application of Therapy in Prostate Cancer. In: Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T. (eds) Hormonal Carcinogenesis V. Advances in Experimental Medicine and Biology, vol 617. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69080-3_18
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