Skip to main content

Women’s Health Initiative Studies of Postmenopausal Breast Cancer

  • Chapter
Hormonal Carcinogenesis V

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 617))

The Women’s Health Initiative (WHI) is a major population research enterprise that aims to generate knowledge and recommendations pertinent to the health of postmenopausal women. The WHI is funded and administered through the USA National Institutes of Health, with the National Heart Lung and Blood Institute having a central role. The WHI is conducted through 40 Clinical Centers in the USA. Our group at the Fred Hutchinson Cancer Research Center in Seattle serves as Clinical Coordinating Center for the WHI, and as the site for one of the Clinical Centers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. The Writing Group for the Women’s Health Initiative Investigators (2002) Risks and benefits of estrogen plus progestin in healthy post-menopausal women: Principal results of the Women’s Health Initiative randomized controlled trial. JAMA 288:321–333.

    Article  Google Scholar 

  2. The Women’s Health Initiative Steering Committee (2004) Effects of conjugated equine estrogen in postmenopausal women with hysterectomy. The Women’s Health Initiative randomized controlled trial. JAMA 291:1701–1712.

    Article  Google Scholar 

  3. Prentice RL, Caan B, Chlebowski RT, et al. (2006) Low-fat dietary pattern and risk of invasive breast cancer: the Women’s Health Initiative Randomized Controlled Dietary Modification Trial. JAMA 295:629–642.

    Article  PubMed  CAS  Google Scholar 

  4. Jackson RD, LaCroix AZ, Gass M, et al. (2006) Calcium plus vitamin D supplementation and the risk for fractures. N Engl J Med 354:669–683.

    Article  PubMed  CAS  Google Scholar 

  5. Wactawski-Wende J, Kotchen JM, Anderson GL, et al. (2006) Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med 354:684–696.

    Article  PubMed  CAS  Google Scholar 

  6. Chlebowski RT, Hendrix SL, Langer RD, et al. (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s Health Initiative Randomized Trial. JAMA 289:3243–3253.

    Article  PubMed  CAS  Google Scholar 

  7. Anderson GL, Chlebowski RT, Rossouw JE, et al. (2006) Prior hormone therapy and breast cancer risk in the Women’s Health Initiative randomized trial of estrogen plus progestin. Maturitas 55:103–115.

    Article  PubMed  CAS  Google Scholar 

  8. Stefanick ML, Anderson GL, Margolis KL, et al. (2006) Effects of conjugated equine estrogens on breast cancer and mammography screening in postmenopausal women with hysterectomy. JAMA 295:1647–1657.

    Article  PubMed  CAS  Google Scholar 

  9. Chen WY, Manson JE, Hankinson SE, et al. (2006) Unopposed estrogen therapy and the risk of invasive breast cancer. Arch Intern Med 166:1027–1032.

    Article  PubMed  CAS  Google Scholar 

  10. Beral V, Million Women Study Collaborators (2003) Breast cancer and hormone replacement therapy in the Million Women Study. Lancet 362:419–427.

    Article  PubMed  CAS  Google Scholar 

  11. Howe GR, Hirohata T, Hislop TG, et al. (1990) Dietary factors and risk of breast cancer: combined analysis of 12 case–control studies. J Natl Cancer Inst 82:561–569.

    Article  PubMed  CAS  Google Scholar 

  12. Hunter DJ, Spiegelman D, Adami HO, et al. (1996) Cohort studies of fat intake and the risk of breast cancer – a pooled analysis. N Engl J Med 334:356–361.

    Article  PubMed  CAS  Google Scholar 

  13. Insull W, Henderson MM, Prentice RL, et al. (1990) Results of a randomized feasibility study of a low-fat diet. Arch Intern Med 150:421–427.

    Article  PubMed  Google Scholar 

  14. Prentice RL, Thompson DJ, Clifford C, et al. (1990) Dietary fat reduction and plasma estradiol concentration among healthy postmenopausal women. J Natl Cancer Inst 82:129–134.

    Article  PubMed  CAS  Google Scholar 

  15. Prentice RL, Qi L (2006) Aspects of the design and analysis of high-dimensional SNP studies for disease risk estimation. Biostatistics 7:339–354.

    Article  PubMed  Google Scholar 

  16. Wang H, Clouthier SG, Galchev V, et al. (2005) Intact-protein-based high-resolution three-dimensional quantitative analysis system for proteome profiling of biological fluids. Mol Cell Proteomics 4:618–625.

    Article  PubMed  CAS  Google Scholar 

  17. Freedman LS, Potischman N, Kipnis V, et al. (2006) A comparison of two dietary instruments for evaluating the fat-breast cancer relationship. Int J Epid 35:1011–1021.

    Article  Google Scholar 

  18. Bingham SA, Luben R, Welch A, et al. (2003) Are imprecise methods obscuring a relationship? Report from the EPIC Norfolk Prospective Cohort Study. Lancet 362:212–214.

    Article  PubMed  Google Scholar 

  19. Bingham SA, Day N (2006) Commentary: Fat and breast cancer: time to re-evaluate both methods and results? Int J Epid 35:1022–1024.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer

About this chapter

Cite this chapter

Prentice, R.L. (2008). Women’s Health Initiative Studies of Postmenopausal Breast Cancer. In: Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T. (eds) Hormonal Carcinogenesis V. Advances in Experimental Medicine and Biology, vol 617. Springer, New York, NY. https://doi.org/10.1007/978-0-387-69080-3_14

Download citation

Publish with us

Policies and ethics