Abstract
The physical and biologic principles of localized high-temperature thermal therapy are well understood. If the targeted tissue volume is heated beyond 57° to 60°C, the threshold for protein denaturation, then coagulation necrosis occurs. This type of thermal treatment results in irreversible cell damage in both normal and neoplastic tissues. Since heat energy deposited above this critical level is not selective, thermal ablation is more comparable to surgery than to the more selective hyperthermia. In the case of cryoablation, the underlying physical and biologic principles are less well understood; nevertheless multiple freezings at a relatively low temperature also result in cell death.
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© 2005 Springer Science+Business Media, Inc.
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Jolesz, F.A. (2005). Image Guidance and Control of Thermal Ablation. In: vanSonnenberg, E., McMullen, W.N., Solbiati, L., Livraghi, T., Müeller, P.R., Silverman, S.G. (eds) Tumor Ablation. Springer, New York, NY. https://doi.org/10.1007/0-387-28674-8_14
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DOI: https://doi.org/10.1007/0-387-28674-8_14
Publisher Name: Springer, New York, NY
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