References
Dawson JK, Quah E, Earnshaw B, Amoasii C, Mudawi T, Spencer LG (2021) Does methotrexate cause progressive fibrotic interstitial lung disease? A systematic review. Rheumatol Int 41:1055–1064. https://doi.org/10.1007/s00296-020-04773-4
Drosos AA, Pelechas E, Voulgari PV (2020) Treatment strategies are more important than drugs in the management of rheumatoid arthritis. Clin Rheumatol 39:1363–1368. https://doi.org/10.1007/s10067-020-05001-x
Turesson C, O’Fallon WM, Crowson CS, Gabriel SE, Matteson EL (2003) Extra-articular disease manifestations in rheumatoid arthritis: incidence trends and risk factors over 46 years. Ann Rheum Dis 62:722–727. https://doi.org/10.1136/ard.62.8.722
Wilsher M, Voight L, Milne D, The M, Good N, Kolbe J et al (2012) Prevalence of airway and parenchymal abnormalities in newly diagnosed rheumatoid arthritis. Respir Med 106:1441–1446. https://doi.org/10.1016/j.rmed.2012.06.020
Perez T, Remy-Jardin M, Cortet B (1998) Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findings. Am J Respir Crit Care Med 157:1658–1665. https://doi.org/10.1164/ajrccm.157.5.9710018
Metafratzi ZM, Georgiadis AN, Ioannidou CV, Alamanos Y, Vassiliou MP, Zikou AK et al (2007) Pulmonary involvement in patients with early rheumatoid arthritis. Scand J Rheumatol 36:338–344. https://doi.org/10.1080/03009740701393957
Georgiadis AN, Metafratzi ZM, Drosos AA (2009) Pulmonary abnormalities in patients with early and longstanding rheumatoid arthritis. J Rheumatol 36:444–445. https://doi.org/10.3899/jrheum.080882
Mori S, Cho I, Koga Y, Sugimoto M (2008) Comparison of pulmonary abnormalities on high-resolution computed tomography in patients with early versus longstanding rheumatoid arthritis. J Rheumatol 35:1513–1521
Demoruelle MK, Weisman MH, Simonian PL, Lynch DA, Sachs PB, Pedraza IF et al (2012) Brief report: airways abnormalities and rheumatoid arthritis-related autoantibodies in subjects without arthritis: early injury or initiating site of autoimmunity? Arthritis Rheum 64:1756–1761. https://doi.org/10.1002/art.34344
Zamora-Legoff JA, Krause ML, Crowson CS, Ryu JH, Matteson EL (2017) Progressive decline of lung function in rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol 69:542–549. https://doi.org/10.1002/art.39971
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Pelechas, E., Georgiadis, A.N., Voulgari, P.V. et al. Methotrexate and interstitial lung disease. Is there a real causative factor?. Rheumatol Int 41, 2045–2046 (2021). https://doi.org/10.1007/s00296-021-04901-8
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DOI: https://doi.org/10.1007/s00296-021-04901-8