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Wiener klinische Wochenschrift
Erschienen in:

01.12.2016 | original article

Xanthelasma palpebrarum associated with increased cardio-ankle vascular index in asymptomatic subjects

verfasst von: Ali Rıza Akyüz, MD, Turhan Turan, Musluhittin Emre Erkuş, İsmail Gürbak, Selim Kul, Levent Korkmaz, Mustafa Tarık Ağaç, Şükrü Çelik

Erschienen in: Wiener klinische Wochenschrift | Sonderheft 8/2016

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Summary

Background

Xanthelasma palpebrarum (XP) is associated with increased risk of ischemic heart disease and myocardial infarction independent of other well-known cardiovascular risk factors. Cardio-ankle vascular index (CAVI) is a novel index of arterial stiffness and important marker of subclinical atherosclerosis. The purpose of this study was to investigate the association between XP and CAVI in asymptomatic subjects.

Methods

Consecutive 50 subjects with XP and age-gender matched 50 control subjects were enrolled. Patients with known atherosclerotic vascular disease were excluded. Arterial stiffness was assessed by CAVI and defined as abnormal if CAVI is ≥ 8.

Results

Subjects with XP had higher mean CAVI than control subjects (8.05 ± 1.72 vs. 6.76 ± 1.18, p < 0.001). Frequency of abnormal CAVI was higher in subjects with XP (n = 27) compared to those without XP (n = 9, 54 vs. 18 %, p < 0.001). There was a significant correlation between XP and CAVI (r = 0.42, p < 0.001). Conditional logistic regression analysis showed that XP (odds ratio OR 8.80, 95 % confidence interval CI 2.63–29.49, p < 0.001) and age (OR 1.17, 95 % CI 1.08–1.26, p < 0.001) were independent predictors for abnormal CAVI.

Conclusion

The study suggests that XP is associated with increased arterial stiffness in asymptomatic subjects.
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Metadaten
Titel
Xanthelasma palpebrarum associated with increased cardio-ankle vascular index in asymptomatic subjects
verfasst von
Ali Rıza Akyüz, MD
Turhan Turan
Musluhittin Emre Erkuş
İsmail Gürbak
Selim Kul
Levent Korkmaz
Mustafa Tarık Ağaç
Şükrü Çelik
Publikationsdatum
01.12.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe Sonderheft 8/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-0989-6

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