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01.04.2015 | review

Vulvar cancer: a review for dermatologists

verfasst von: Anastasiya Atanasova Chokoeva, MD, Prof Georgi Tchernev, MD, Elena Castelli, MD, Elisabetta Orlando, MD, Shyam B. Verma, MBBS, DV & D, Markus Grebe, MD, Prof Uwe Wollina, MD

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 7-8/2015

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Summary

Vulvar malignancies are important tumors of the female reproductive system. They represent a serious health issue with an incidence between 2 and 7 per 100,000 and year. We provide a review about most important cancer entities, i.e., melanoma, squamous cell carcinoma, basal cell carcinoma, neuroendocrine cancer, and skin adnexal malignancies.

Squamous cell carcinoma is the most common vulvar malignancy that can develop from vulvar intraepithelial neoplasia or de novo. Basal cell carcinoma represents only 2 % of all vulvar cancers. Melanoma of the vulva exists in two major types—superficial spreading and acral lentiginous. A special feature is the occurrence of multiple vulvar melanomas. Of the adnexal cancer types Paget’s disease and carcinoma are seen more frequently than other adnexal malignancies. The dermatologist should be aware of this problem, since he might be the first to be consulted by patients for vulvar disease. Treatment should be interdisciplinary in close association to gynecologists, oncologists, and radiologists.

Vorheriger Artikel Das Fleckfieber und die Erfindung seiner Serodiagnose und Impfung bei der k. u. k. Armee im Ersten Weltkrieg

Akhtar-Danesh N, Elit L, Lytwyn A. Trends in incidence and survival of women with invasive vulvar cancer in the United States and Canada: a population-based study. Gynecol Oncol 2014;134:314–8.PubMed

Robert Koch-Institut & Gesellschaft der epidemiologischen Krebsregister in Deutschland e. V. Krebs in Deutschland 2009/2010. Beiträge zur Gesundheitsberichterstattung des Bundes, 9. Ausgabe. Berlin: Robert-Koch-Institut; 2013. pp. 72–6.

Pathak D, Agrawal S, Dhali TK. Prevalences of and risk factors for vulvar diseases in Nepal: a hospital-based study. Int J Dermatol 2011;50:161–7.PubMed

Dittmer C, Katalinic A, Mundhenke C, Thill M, Fischer D. Epidemiology of vulvar and vaginal cancer in Germany. Arch Gynecol Obstet 2011;284:169–74.PubMed

Bromfield ME, Gibson TN, Hanchard B, Waugh N, McNaughton D. A Thirty-year review of vulvar cancer in Jamaica, 1978 to 2007. West Indian Med J 2014;63:138–41.

Deliveliotou A, Creatsas G. Anatomy of the vulva. In: Farage MA, Maibach HI, editors. The vulva. Anatomy, physiology, and pathology. Informa Healthcare, New York; 2006. pp. 1–8.

Wollina U, Hansel G, Koch A, et al. Diagnostik und therapeutisches Vorgehen bei extrakutanem Melanom und unbekanntem Primarius. In: Szeimies R-M, Hauschild A, Garbe C, Kaufmann R, Landthaler M, editors. Tumoren der Haut. Grundlagen, Diagnostik und Therapie in der dermatologischen Onkologie. G Thieme Verlag, Stuttgart; 2010. pp. 404–14.

Murzaku EC, Penn LA, Hale CS, Keltz Pomeranz M, Polsky D. Vulvar nevi, melanosis, and melanoma: an epidemiologic, clinical, and histopathologic review. J Am Acad Dermatol 2014;71:12412–9.

Tcheung WJ, Selim MA, Herndon JE 2nd, et al. Clinicopathologic study of 85 cases of melanoma of the female genitalia. J Am Acad Dermatol 2012;67:598–605.PubMed

10.

Baderca F, Cojocaru S, Lazăr E, et al. Amelanotic vulvar melanoma: case report and review of the literature. Rom J Morphol Embryol 2008;49:219–28.PubMed

11.

Moan J, Porojnicu AC, Dahlback A, Grant WB, Juzeniene A. Where the sun does not shine: is sunshine protective against melanoma of the vulva? J Photochem Photobiol B 2010;101:179–83.PubMed

12.

Ragnarsson-Olding BK. Spatial density of primary malignant melanoma in sun-shielded body sites: a potential guide to melanoma genesis. Acta Oncol 2011;50:323–8.PubMed

13.

Aulmann S, Sinn HP, Penzel R, et al. Comparison of molecular abnormalities in vulvar and vaginal melanomas. Mod Pathol 2014;27:1386–93.PubMed

14.

Massi G, LeBoit PE. Melanoma on genital skin. In: Massi G, LeBoit PE, editors. Histological diagnosis of nevi and melanoma. 2nd Edn. Heidelberg—Berlin: Springer; 2014. pp 653–62.

15.

Carlson JA, Mu XC, Slominski A, Weismann K, et al. Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol 2002;138:77–87.PubMed

16.

Ferrari A, Zalaudek I, Argenziano G, et al. Dermoscopy of pigmented lesions of the vulva: a retrospective morphological study. Dermatology. 2011;222:157–66.PubMed

17.

Wollina U, Burroni M, Torricelli R, et al. Digital dermoscopy in clinical practise: a three-centre analysis. Skin Res Technol. 2007;13:133–42.PubMed

18.

van Engen-van Grunsven AC, Küsters-Vandevelde HV, De Hullu J, et al. NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract—a study of 24 cases from the Netherlands. Gynecol Oncol. 2014;134:10–4.

19.

Mehra T, Grözinger G, Mann S, et al. Primary localization and tumor thickness as prognostic factors of survival in patients with mucosal melanoma. PLoS One. 2014;9:e112535.PubMedCentralPubMed

20.

Balch CM, Gershenwald JE, Soong S, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol. 2009;27:6199–206.PubMedCentralPubMed

21.

Pflugfelder A, Kochs C, Blum A, et al. Malignant melanoma S3-guideline “Diagnosis, therapy and follow-up of melanoma”. J Dtsch Dermatol Ges. 2013;6:1–116, 1–126.

22.

Leitao MM Jr. Management of vulvar and vaginal melanomas: current and future strategies. Am Soc Clin Oncol Educ Book. 2014:e277–81.

23.

Trifirò G, Travaini LL, Sanvito F, et al. Sentinel node detection by lymphoscintigraphy and sentinel lymph node biopsy in vulvar melanoma. Eur J Nucl Med Mol Imaging. 2010;37:736–41.PubMed

24.

Moxley KM, Fader AN, Rose PG, et al. Malignant melanoma of the vulva: an extension of cutaneous melanoma? Gynecol Oncol. 2011;122:612–7.PubMed

25.

Yuan GW, Wu LY, Zhang R, Li XG. Clinical analysis for 18 cases of vulvar Bowen’s disease. Zhonghua Fu Chan Ke Za Zhi. 2013;48:925–8.PubMed

26.

Lazaridou E, Fotiadou C, Giannopoulou C, Ioannides D. Persistent erythematous lesion of the vulva: a diagnostic and treatment challenge. J Drugs Dermatol. 2012;11:110–2.PubMed

27.

Kang HK, Yun JH, Son YM, Roh JY, Lee JR. Photodynamic therapy for Bowen’s disease of the vulva area. Ann Dermatol. 2014;26:241–5.PubMedCentralPubMed

28.

van de Nieuwenhof HP, van der Avoort IA, de Hullu JA. Review of squamous premalignant vulvar lesions. Crit Rev Oncol Hematol. 2008;68:131–56.PubMed

29.

Preti M, Scurry J, Marchitelli CE, Micheletti L. Vulvar intraepithelial neoplasia. Best Pract Res Clin Obstet Gynaecol. 2014;28:1051–62 (pii: S1521-6934(14)00134-5).PubMed

30.

Léonard B, Kridelka F, Delbecque K, et al. A clinical and pathological overview of vulvar condyloma acuminatum, intraepithelial neoplasia, and squamous cell carcinoma. Biomed Res Int. 2014;2014:480573.PubMedCentralPubMed

31.

Chiesa-Vottero A, Dvoretsky PM, Hart WR. Histopathologic study of thin vulvar squamous cell carcinomas and associated cutaneous lesions: a correlative study of 48 tumors in 44 patients with analysis of adjacent vulvar intraepithelial neoplasia types and lichen sclerosus. Am J Surg Pathol. 2006;30:310–8.PubMed

32.

Kjaer SK, Sigurdsson K, Iversen OE, et al. A pooled analysis of continued prophylactic efficacy of quadrivalent human papillomavirus (Types 6/11/16/18) vaccine against high-grade cervical and external genital lesions. Cancer Prev Res (Phila). 2009;2:868–78.

33.

Couto E, Sæterdal I, Juvet LK, Klemp M. HPV catch-up vaccination of young women: a systematic review and meta-analysis. BMC Public Health. 2014;14:867.PubMedCentralPubMed

34.

Gentile M, Bianchi P, Sesti F, et al. Adjuvant topical treatment with imiquimod 5 % after excisional surgery for VIN 2/3. Eur Rev Med Pharmacol Sci. 2014;18:2949–52.PubMed

35.

Tristram A, Hurt CN, Madden T, et al. Activity, safety, and feasibility of cidofovir and imiquimod for treatment of vulval intraepithelial neoplasia (RT3VIN): a multicentre, open-label, randomised, phase 2 trial. Lancet Oncol. 2014;15:1361–8 (pii: S1470-2045(14)70456-5).PubMed

36.

Judson PL, Habermann EB, Baxter NN, Durham SB, Virnig BA. Trends in the incidence of invasive and in situ vulvar carcinoma. Obstet Gynecol. 2006;107:1018–22.PubMed

37.

Hasanzadeh M, Zamiri-Akhlaghi A, Hassanpoor-Moghaddam M, Shahidsales S. Vulvar carcinoma in pregnant women aged less than 40 years: case report. Iran J Cancer Prev. 2014;7:175–8.PubMedCentralPubMed

38.

Ciszko B, Pochwałowski M, St Gabryś M. Risk factors and clinical characteristic patients with vulvar cancer. Ginekol Pol. 2006;77:914–21.PubMed

39.

Aragona AM, Cuneo NA, Soderini AH, Alcoba EB. An analysis of reported independent prognostic factors for survival in squamous cell carcinoma of the vulva: is tumor size significance being underrated? Gynecol Oncol. 2014;132:643–8.PubMed

40.

Simbiri KO, Jha HC, Kayembe MK, Kovarik C, Robertson ES. Oncogenic viruses associated with vulva cancer in HIV-1 patients in Botswana. Infect Agent Cancer. 2014;9:28.PubMedCentralPubMed

41.

van Seters W, ten Kate FJW, van Beurden M, Verheijen RHM, et al. In the absence of (early) invasive carcinoma, vulvar intraepithelial neoplasia associated with lichen sclerosus is mainly of undifferentiated type: new insights in histology and aetiology. J Clin Pathol. 2007;60:504–9.PubMedCentralPubMed

42.

Chulvis do Val IC, Almeida Filho GL, Valiante PM, Gondim C, Takiya CM, Carvalho Mda G. Vulvar intraepithelial neoplasia p53 expression, p53 gene mutation and HPV in recurrent/progressive cases. J Reprod Med. 2004;49:868–74.PubMed

43.

Trietsch MD, Spaans VM, Ter Haar NT, et al. CDKN2A (p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma. Gynecol Oncol. 2014;135:149–55.PubMed

44.

Li YZ, Li SL, Li X, et al. Expression of endogenous hypoxia markers in vulvar squamous cell carcinoma. Asian Pac J Cancer Prev. 2012;13:3675–80.PubMed

45.

Zanvettor PH, Filho DF, Soares FA, Neves AR, Palmeira LO. Study of biomolecular and clinical prognostic factors in patients with cancer of the vulva undergoing surgical treatment. Int J Gynecol Cancer. 2014;24:766–72.PubMed

46.

Pecorelli S. Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009;105:103–4.PubMed

47.

O’Shea C, Fitzpatrick JE, Koch PJ. Desmosomal defects in acantholytic squamous cell carcinomas. J Cutan Pathol. 2014;41:873–9.PubMed

48.

Sznurkowski JJ, Milczek T, Emerich J. Prognostic factors and a value of 2009 FIGO staging system in vulvar cancer. Arch Gynecol Obstet. 2013;287:1211–8.PubMedCentralPubMed

49.

Verma SB, Wollina U. Condyloma-like squamous cell carcinoma of the vulva: report of two midline cases. Clin Cosmet Investig Dermatol. 2012;5:129–33.PubMedCentralPubMed

50.

Deka P, Barmon D, Shribastava S, Kataki AC, Sharma JD, Bhattacharyya M. Prognosis of vulvar cancer with lymph node status and size of primary lesion: a survival study. J Midlife Health. 2014;5:10–3.PubMedCentralPubMed

51.

Lawrie TA, Patel A, Martin-Hirsch PP, et al. Sentinel node assessment for diagnosis of groin lymph node involvement in vulval cancer. Cochrane Database Syst Rev. 2014;6:CD010409.PubMed

52.

Robison K, Roque D, McCourt C, et al. Long-term follow-up of vulvar cancer patients evaluated with sentinel lymph node biopsy alone. Gynecol Oncol. 2014;133:416–20.PubMed

53.

Herr D, Juhasz-Boess I, Solomayer EF. Therapy for primary vulvar carcinoma. Geburtshilfe Frauenheilkd. 2014;74:271–5.PubMedCentralPubMed

54.

Micheletti L, Preti M. Surgery of the vulva in vulvar cancer. Best Pract Res Clin Obstet Gynaecol. 2014;28:1074–87 (pii: S1521-6934(14)00135-7).PubMed

55.

Bogani G, Cromi A, Serati M, et al. Predictors and patterns of local, regional, and distant failure in squamous cell carcinoma of the vulva. Am J Clin Oncol. 2014 [Epub ahead of print].

56.

Graham K, Burton K. “Unresectable” vulval cancers: is neoadjuvant chemotherapy the way forward? Curr Oncol Rep. 2013;15:573–80.PubMed

57.

Expert Panel on Radiation Oncology-Gynecology, Kidd E, Moore D, et al. ACR Appropriateness Criteria® management of locoregionally advanced squamous cell carcinoma of the vulva. Am J Clin Oncol. 2013;36:415–22.

58.

Iavazzo C, Fotiou S, Salakos N, Bakalianou K, Kondi-Pafiti A. HPV-related verrucous carcinoma of the vulva. A case report and literature review. Eur J Gynaecol Oncol. 2011;32:680–1.PubMed

59.

Boujoual M, Hachi H, Rimani M, El Khannoussi B, Bougtab A. Verrucous carcinoma of the vulva: report of four cases. Pan Afr Med J. 2014;17:303.PubMedCentralPubMed

60.

Spinu D, Rădulescu A, Bratu O, Checheriţă IA, Ranetti AE, Mischianu D. Giant condyloma acuminatum—Buschke-Lowenstein disease—a literature review. Chirurgia (Bucur). 2014;109:445–50.

61.

Levy A, Lebbe C. Buschke-Löwenstein tumor: diagnosis and treatment. Ann Urol (Paris). 2006;7:175–8.

62.

Indinnimeo M, Impagnatiello A, D’Ettorre G, et al. Buschke-Löwenstein tumor with squamous cell carcinoma treated with chemo-radiation therapy and local surgical excision: report of three cases. World J Surg Oncol. 2013;11:231.PubMedCentralPubMed

63.

Ulas M, Bostanci EB, Teke Z, et al. Giant anorectal condyloma acuminatum of Buschke-Löwenstein: successful plastic reconstruction with bilateral gluteal musculocutaneous v-y advancement flap. Indian J Surg. 2013;75(Suppl 1):168–70.PubMedCentralPubMed

64.

Santos-Briz A, Antúnez P, López-Ríos F, Rodríguez-Peralto JL, Garzón A. Human papillomavirus-negative spindle cell carcinoma of the vulva associated with lichen sclerosus: case report and literature review. Am J Dermatopathol. 2002;24:135–8.PubMed

65.

Bigby SM, Eva LJ, Jones RW. Spindle cell carcinoma of the vulva: a series of 4 cases and review of the literature. Int J Gynecol Pathol. 2014;33:203–12.PubMed

66.

Choi DS, Lee JW, Lee SJ, et al. Squamous cell carcinoma with sarcomatoid features of the vulva: a case report and review of literature. Gynecol Oncol. 2006;103:363–7.PubMed

67.

Kanitakis J, Arbona-Vidal E, Faure M. Extensive pigmented vulvar basal-cell carcinoma presenting as pruritus in an elderly woman. Dermatol Online J. 2011;17:8.PubMed

68.

Saini R, Sarnoff DS. Basal cell carcinoma of the vulva presenting as unilateral pruritus. J Drugs Dermatol. 2008;7:288–90.PubMed

69.

Asuman C, Ozlem A, Burçak T, Onder P. An unusual location of basal cell carcinoma: the clitoris and the vulva. Indian J Dermatol. 2008;53:192–4.PubMedCentralPubMed

70.

Pisani C, Poggiali S, De Padova L, Andreassi A, Bilenchi R. Basal cell carcinoma of the vulva. J Eur Acad Dermatol Venereol. 2006;20:446–8.PubMed

71.

Kara M, Colgecen E, Yildirim EN. Vulvar basal cell carcinoma. Indian J Pathol Microbiol. 2012;55:583–4.PubMed

72.

Wollina U, Pabst F, Krönert C, et al. High-risk basal cell carcinoma: an update. Exp Rev Dermatol. 2010;5:357–68.

73.

Perrone T, Twiggs LB, Adcock LL, Dehner LP. Vulvar basal cell carcinoma: an infrequently metastasizing neoplasm. Int J Gynecol Pathol. 1987;6:152–65.PubMed

74.

Elwood H, Kim J, Yemelyanova A, Ronnett BM, Taube JM. Basal cell carcinomas of the vulva: high-risk human papillomavirus DNA detection, p16 and BerEP4 expression. Am J Surg Pathol. 2014;38:542–7.PubMed

75.

Mulvany NJ, Rayoo M, Allen DG. Basal cell carcinoma of the vulva: a case series. Pathology. 2012;44:528–33.PubMed

76.

Rouzbahman M, Clarke B. Neuroendocrine tumors of the gynecologic tract: select topics. Semin Diagn Pathol. 2013;30:224–33.PubMed

77.

Sheikh ZA, Nair I, Vijaykumar DK, Jojo A, Nandeesh M. Neuroendocrine tumor of vulva: a case report and review of literature. J Cancer Res Ther. 2010;6:365–6.PubMed

78.

Hierro I, Blanes A, Matilla A, Muñoz S, Vicioso L, Nogales FF. Merkel cell (neuroendocrine) carcinoma of the vulva. A case report with immunohistochemical and ultrastructural findings and review of the literature. Pathol Res Pract. 2000;196:503–9.PubMed

79.

Jońska-Gmyrek J, Bobkiewicz P, Gmyrek L, Zółciak-Siwińska A, Lindner B, Staniaszek J. Merkel cell carcinoma of the vulva—case report and the literature review. Ginekol Pol. 2013;84:385–9.PubMed

80.

Cardoso JC, Teixeira V, Tchernev G, Wollina U. Merkel cell carcinoma: a review and update on aetiopathogenesis, diagnosis and treatment approaches. Wien Med Wochenschr. 2013;163:359–67.PubMed

81.

Iavazzo C, Terzi M, Arapantoni-Dadioti P, Dertimas V, Vorgias G. Vulvar Merkel carcinoma: a case report. Case Rep Med. 2011;2011:546972.PubMedCentralPubMed

82.

Mharrech A, Benchakroun N, Tawfiq N, et al. Small-cell carcinoma of the vulva. J Gynecol Obstet Biol Reprod (Paris). 2006;35:834–83.

83.

Atienza-Amores M, Guerini-Rocco E, Soslow RA, Park KJ, Weigelt B. Small cell carcinoma of the gynecologic tract: a multifaceted spectrum of lesions. Gynecol Oncol. 2014;134:410–8.PubMed

84.

Matsumoto R, Bito T, Washio K, et al. Primary cutaneous small cell carcinoma of the vulva arising from squamous cell carcinoma. Br J Dermatol. 2011;165:1147–8.PubMed

85.

Cohen J, Chan JK, Kapp DS. The management of small-cell carcinomas of the gynecologic tract. Curr Opin Oncol. 2012;24:572–9.PubMed

86.

Eckert F, Fehm T, Bamberg M, Müller AC. Small cell carcinoma of vulva: curative multimodal treatment in face of resistance to initial standard chemotherapy. Strahlenther Onkol. 2010;186:521–4.PubMed

87.

Jiménez-Ayala M, Pinedo Moraleda F, Rodríguez Alvarez MC. Glandular lesions of the vulva. Monogr Clin Cytol. 2011;20:77–86.PubMed

88.

Robson A, Lazar AJ, Nagi JB, et al. Primary cutaneous apocrine carcinoma: a clinicopathologic analysis of 24 cases. Am J Surg Pathol. 2008;32:682–90.PubMed

89.

Bagwan IN, Taylor A, Dina R. Metastatic apocrine carcinoma of female genital tract. J Clin Pathol. 2009;62:287–88.PubMed

90.

Van der Putte SCJ, van Gorp LHM. Adenocarcinoma of the mammary-like glands of the vulva: A concept unifying sweat gland carcinoma of the vulva, carcinoma of supernumerary mammary glands and extramammary Paget’s disease. J Cutan Pathol. 1994;21:157–63.PubMed

91.

Hou JL, Wu LY, Zhang HT, Lv NN, Huang Y, Yu GZ. Clinicopathologic characteristics of 12 patients with vulvar sweat gland carcinoma. Int J Gynecol Cancer. 2010;20:874–8.PubMed

92.

Tang QL, Jiang XF, Lin ZQ, Li HG, Wang YA, Luo X. Primary adenoid cystic carcinoma of sweat glands in vulva: report of an unusual case and review of the literature. J Obstet Gynaecol Res. 2011;37:1694–7.PubMed

93.

Sahincioğlu O, Berker B, Güngör M, Kankaya D, Sertçelik A. Adenoid cystic carcinoma of the Bartholin’s gland: a rare tumor unmarked by persistent vulvar pain in a postmenopausal woman. Arch Gynecol Obstet. 2008;278:473–6.PubMed

94.

Zhan P, Li G, Liu B, Mao XG. Bartholin gland carcinoma: a case report. Oncol Lett. 2014;8:849–51.PubMedCentralPubMed

95.

Kajal B, Talati H, Daya D, Alowami S. Apocrine adenocarcinoma of the vulva. Rare Tumors. 2013;5:e40.PubMedCentralPubMed

96.

Chraibi Z, Hebert T, Body G, Arbion F, Ouldamer L. Bartholin’s gland carcinoma. Gynecol Obstet Fertil. 2014;42:540–2.PubMed

97.

Obermair A, Koller S, Crandon AJ, Perrin L, Nicklin JL. Primary Bartholin gland carcinoma: a report of seven cases. Aust N Z J Obstet Gynaecol. 2001;41:78–81.PubMed

98.

Kozakiewicz B, Dmoch-Gajzlerska E, Roszkowska-Purska K. Carcinomas and sarcomas of Bartholin gland. A report of nine cases and review of the literature. Eur J Gynaecol Oncol. 2014;35:243–9.PubMed

99.

Agolli L, Osti MF, Armosini V, De Sanctis V, Valeriani M, Enrici RM. Adenoid cystic carcinoma of Bartholin’s gland receiving adjuvant radiation therapy: case report. Eur J Gynaecol Oncol. 2013;34:487–8.PubMed

100.

Ohno T, Nakano T, Abe A, Sano T, Niibe Y, Oka K. Mucinous adenocarcinoma of Bartholin gland treated with radiation therapy: a case report. Jpn J Clin Oncol. 2001;31:226–30.PubMed

101.

Chung-Park M, Zheng Liu C, Giampoli EJ, Emery JD, Shalodi A. Mucinous adenocarcinoma of ectopic breast tissue of the vulva. Arch Pathol Lab Med. 2002;126:1216–8.PubMed

102.

Alsaad KO, Obaidat N, Dube V, Chapman W, Ghazarian D. Vulvar apocrine adenocarcinoma: a case with nodal metastasis and intranodal mucinous differentiation. Pathol Res Pract 2009;205:131–5.PubMed

103.

Lee S, Nodit L. Phyllodes tumor of vulva: a brief diagnostic review. Arch Pathol Lab Med. 2014;138:1546–50.PubMed

104.

Gavriilidis P, Chrysanthopoulos K, Gerasimidou D. Extramammary Paget’s disease of the vulva. BMJ Case Rep. 2013;pii:bcr2013200623.

105.

Wollina U. Extensive extramammary Paget’s disease: surgical treatment. J Cutan Aesthet Surg. 2013;6:40–4.

106.

Barmon D, Kataki AC, Imchen L, Sharma JD. Extra mammary Paget’s disease of the vulva. J Midlife Health. 2012;3:100–2.PubMedCentralPubMed

107.

Cooper JC, Hew KE, Audlin KM, Im DD, Matsuo K. Synchronous of breast and vulvar Paget’s disease: a case report. Eur J Gynaecol Oncol. 2012;33:534–6.PubMed

108.

Kim S-A, Kwon J-I, Jung H-R, Lee K-S, Cho J-W. Primary extramammary Paget’s disease combined with Bowen’s disease in vulva. Ann Dermatol. 2011;23(Suppl 2):S222–5.PubMedCentralPubMed

109.

Clayton EF, Rubin SC, Dumoff KL. Paget cells in endometrial and endocervical curettings in a patient with recurrent vulvar Paget’s disease. Int J Surg Pathol. 2013;22:374–7.PubMed

110.

Ladak A, Bramley M, Titi S. Unilateral pigmented extramammary Paget’s disease of the axilla associated with a benign mole: a case study and a review of literature. Korean J Pathol. 2014;48:292–6.PubMedCentralPubMed

111.

Luyten A, Sörgel P, Clad A, et al. Interventions for the treatment of Paget’s disease of the vulva. Cochrane Database Syst Rev. 2013;10:CD009245.

112.

Lellé RJ, Harter P, Buttmann N, Petry KU. Treatment of extramammary Paget disease of the vulva with imiquimod: a retrospective, multicenter study by the German Colposcopy Network. J Am Acad Dermatol. 2014;70:644–50.PubMed

113.

Nardelli AA, Stafinski T, Menon D. Effectiveness of photodynamic therapy for mammary and extra-mammary Paget’s disease: a state of the science review. BMC Dermatol. 2011;11:13.PubMedCentralPubMed

114.

Hata M, Koike I, Wada H, et al. Postoperative radiation therapy for extramammary Paget’s disease. Br J Dermatol. 2015;172:1014–20. doi:10.1111/bjd.13357.

115.

Nomura H, Matoda M, Okamoto S, Kondo E, Omatsu K, Kato K, Takeshima N. Clinicopathologic features and treatment outcomes of primary extramammary Paget disease of the vulva. J Low Genit Tract Dis. 2015;19:145–8.

Titel: Vulvar cancer: a review for dermatologists
verfasst von: Anastasiya Atanasova Chokoeva, MD
Prof Georgi Tchernev, MD
Elena Castelli, MD
Elisabetta Orlando, MD
Shyam B. Verma, MBBS, DV & D
Markus Grebe, MD
Prof Uwe Wollina, MD
Publikationsdatum: 01.04.2015
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift / Ausgabe 7-8/2015
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-015-0354-9

Springer Medizin Österreich

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