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Erschienen in: Wiener klinische Wochenschrift 17-18/2015

01.09.2015 | original article

Vitamin D levels and comorbidities in ambulatory and hospitalized patients in Austria

verfasst von: MD Christian Muschitz, MD Roland Kocijan, MSc Verena Stütz, MSc Alexandra Kaider, MD, PhD Gabriela Katharina Muschitz, MD Heinrich Resch, MD Stylianos Kapiotis

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 17-18/2015

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Summary

Vitamin D in its hormonal active form, 1,25-dihydroxyvitamin D (calcitriol), has a major impact on bone turnover by regulating calcium and phosphate homoeostasis. By binding the active vitamin D hormone to the vitamin D receptor (VDR), it acts as a nuclear transcription factor (Bouillon et al., Endocr Rev 29(6):726–776, 2008). The discovery that almost all tissues and cells in the body express the VDR and that several tissues possess the enzymatic capability to convert 25-hydroxyvitamin D (25(OH)-D3; cholecalciferol) to the active form, suggests that vitamin D fulfills various extra-osseous functions (Bouillon et al., Endocr Rev 29(6):726–776, 2008; Holick, N Engl J Med 357(3):266–281, 2007). For example, VDR ensures adequate intestinal calcium absorption by regulating the synthesis of several calcium transport proteins in the duodenum (Bouillon et al., Endocr Rev 29(6):726–776, 2008). Additionally, vitamin D is important for proper muscle function, and some studies suggest it may contribute to prevent type 1 diabetes mellitus, certain autoimmune diseases, hypertension, and several types of cancer (Holick, N Engl J Med 357(3):266–281, 2007).
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Metadaten
Titel
Vitamin D levels and comorbidities in ambulatory and hospitalized patients in Austria
verfasst von
MD Christian Muschitz
MD Roland Kocijan
MSc Verena Stütz
MSc Alexandra Kaider
MD, PhD Gabriela Katharina Muschitz
MD Heinrich Resch
MD Stylianos Kapiotis
Publikationsdatum
01.09.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 17-18/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0824-5

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