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Erschienen in: Journal für Klinische Endokrinologie und Stoffwechsel 4/2017

01.12.2017 | Originalien

Vitamin D bei kritisch kranken Erwachsenen

verfasst von: Elisabeth Altendorfer, Steven Amrein, Karin Amrein

Erschienen in: Journal für Klinische Endokrinologie und Stoffwechsel | Ausgabe 4/2017

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Zusammenfassung

Einleitung und Ziele

Studien der letzten Jahrzehnte brachten neue Erkenntnisse über die Rolle von Vitamin D in einer Vielzahl von Erkrankungen. Momentan wird der Vitamin-D-Mangel als modifizierbarer Risikofaktor für Morbidität und Mortalität bei Intensivpatienten diskutiert. Ziel dieser Arbeit ist es, einen Überblick über die zu dem Thema bisher veröffentlichten Studien und deren Ergebnisse zu geben.

Methoden

Für diese Arbeit wurde die Methode einer Literaturstudie gewählt. Nach relevanter medizinischer Fachliteratur wurde über PubMed gesucht.

Ergebnisse

Es wurden 30 Beobachtungsstudien im ICU-Setting (Intensive Care Unit), vier ICU-Beobachtungsstudien bei Kindern und neun relevante Beobachtungsstudien außerhalb des ICU-Settings gefunden. Seit 2003 wurden in Österreich, Belgien, Australien und den USA neun randomisiert kontrollierte Studien zu Vitamin-D-Supplementation bei kritisch kranken Erwachsenen mit Teilnehmerzahlen zwischen 25 und 475 durchgeführt (gesamt n = 716). In den Interventionsstudien zeigte sich ein relatives Mortalitätsrisiko von 0,69 bis 1,17 (gesamt 0,70).

Schlussfolgerungen

Ein Vitamin-D-Mangel bei kritisch Kranken ist weltweit häufig und mit schlechtem Outcome assoziiert. Bisher gibt es vielversprechende, jedoch heterogene und daher unzulängliche Daten zum potenziellen Benefit einer hochdosierten, kostengünstigen Vitamin-D-Substitution in diesem vulnerablen Kollektiv. Um die vermuteten positiven Effekte einer Vitamin-D-Substitution zu bestätigen, bedarf es dringend großer Phase-III-Interventionsstudien bei kritisch kranken Erwachsenen und Kindern.
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Metadaten
Titel
Vitamin D bei kritisch kranken Erwachsenen
verfasst von
Elisabeth Altendorfer
Steven Amrein
Karin Amrein
Publikationsdatum
01.12.2017
Verlag
Springer Vienna
Erschienen in
Journal für Klinische Endokrinologie und Stoffwechsel / Ausgabe 4/2017
Print ISSN: 1998-7773
Elektronische ISSN: 1998-7781
DOI
https://doi.org/10.1007/s41969-017-0009-0