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18.11.2024 | original article

Value of mean platelet volume for diagnosing esophagitis in children with gastroesophageal reflux disease

verfasst von: Azin Gouran, MD, Prof. Mohammadreza Esmaeili dooki, MD, Assistant Professor Hossein-Ali Nikbakht, Associate Professor Hassan Mahmoodi, MD, Mohammad Pornasrolah, PhD, Maryam Nikpour, PhD, Associate Professor Sanaz Mehrabani, MD

Erschienen in: Wiener Medizinische Wochenschrift

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Summary

Background

The prevalence of gastroesophageal reflux disease (GERD) in children is increasing in different societies. This study aims to investigate the value of mean platelet volume (MPV) for diagnosing esophagitis in children with GERD.

Methods

This cross-sectional study conducted at Amirkola Children’s Hospital between 2022 and 2023 involved children aged 2 to 16 years diagnosed with GERD. The diagnosis was based on the GSQ-YC and GASP‑Q questionnaires. All patients underwent endoscopy, with a biopsy for pathology and a blood sample for MPV analysis. The data were then analyzed using SPSS software version 22 (IBM Corp., Armonk, NY, USA), with a significance level set at lower than 0.05.

Results

The frequency of esophagitis among 194 participants was 39.7%. The overall sensitivity and specificity of MPV for diagnosing esophagitis in children were 64.63% and 52.14%, respectively (area under the curve [AUC] = 0.59). In terms of gender, the overall sensitivity and specificity of the MPV were 85.00% and 32.65% in boys and 70.27% and 51.47% in girls (AUC = 0.58 and AUC = 0.61, respectively). In terms of age, the overall sensitivity and specificity of MPV in children under 12 years were 52.46% and 62.26% and in children older than 12 years 87.5% and 36.36% (AUC = 0.58 and AUC = 0.55, respectively).

Conclusion

In summary, the results of this study indicate that MPV is not a reliable method for diagnosing esophagitis in children with GERD.

Rudolph CD, Mazur LJ, Liptak GS, Baker RD, Boyle JT, Colletti RB, et al. Guidelines for evaluation and treatment of gastroesophageal reflux in infants and children: recommendations of the north American society for pediatric gastroenterology and nutrition. J Pediatr Gastroenterol Nutr. 2001;32:S1–S31.CrossRefPubMed

Fass R. Gastroesophageal Reflux Disease. N Engl J Med. 2022;387(13):1207–16.CrossRefPubMed

Maret-Ouda J, Markar SR, Lagergren J. Gastroesophageal reflux disease: a review. JAMA. 2020;324(24):2536–47.CrossRefPubMed

Boulton KH, Dettmar PW. A narrative review of the prevalence of gastroesophageal reflux disease (GERD). Ann Esophagus. 2022;5(7).

Baklola M, Terra M, Badr A, Fahmy FM, Elshabrawy E, Hawas Y, et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol. 2023;23(1):269. https://doi.org/10.1186/s12876-023-02899-w.CrossRefPubMedPubMedCentral

Gold BD. Outcomes of pediatric gastroesophageal reflux disease: in the first year of life, in childhood, and in adults… oh, and should we really leave Helicobacter pylori alone? J Pediatr Gastroenterol Nutr. 2003;37:S33–S9.CrossRefPubMed

Tolia V, Essenmacher L, Ager J. Gastroesophageal reflux disease (GERD) impairs the quality of life in pediatric patients: 31. J Pediatr Gastroenterol Nutr. 2005;41(4):502.CrossRef

Sintusek P, Mutalib M, Thapar N. Gastroesophageal reflux disease in children: what’s new right now? World J Gastrointest Endosc. 2023;15(3):84.CrossRefPubMedPubMedCentral

Gado A, Ebeid B, Abdelmohsen A, Axon A. Prevalence of reflux esophagitis among patients undergoing endoscopy in a secondary referral hospital in Giza, Egypt. Alex J Med. 2015;51(2):89–94. https://doi.org/10.1016/j.ajme.2013.09.002.CrossRef

10.

Antunes CSA. Esophagitis. In: Statpearls. Treasure Island (FL): StatPearls; 2023.

11.

Putnam PE. Eosinophilic esophagitis in children: clinical manifestations. Gastrointest Endosc Clin N Am. 2008;18(1):11–23.CrossRefPubMed

12.

Roh JH, Ryoo E, Tchah H. Clinical manifestations of eosinophilic esophagitis in children and adolescents: a single-center, matched case-control study. Pediatr Gastroenterol Hepatol Nutr. 2020;23(4):319.CrossRefPubMedPubMedCentral

13.

Muñoz FV, Almeida PH, Carrión-Jaramillo E, Montalvo AV. Clinical features of eosinophilic esophagitis: a single center experience in ecuador. Pediatr Gastroenterol Hepatol Nutr. 2022;25(4):293.CrossRefPubMedPubMedCentral

14.

Villarín AL. Eosinophilic esophagitis—clinical manifestations, diagnosis, and treatment. Rev Esp Enferm Dig. 2009;101(1):49–59.

15.

Rohan CJ, Lohade RP, Brewer C, Travers JB. Platelet-activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury. Biofactors. 2022;48(6):1250–6.CrossRefPubMedPubMedCentral

16.

Matowicka-Karna J. Markers of inflammation, activation of blood platelets and coagulation disorders in inflammatory bowel diseases. Postepy Hig Med Dosw. 2016;70:305–12. https://doi.org/10.5604/17322693.1199305.CrossRef

17.

Iida H, Kaibori M, Matsui K, Ishizaki M, Kon M. Ratio of mean platelet volume to platelet count is a potential surrogate marker predicting liver cirrhosis. World J Hepatol. 2018;10(1):82–7. https://doi.org/10.4254/wjh.v10.i1.82.CrossRefPubMedPubMedCentral

18.

Akar T. Can mean platelet volume IndIcate HelIcobacter posItIvIty and severIty of gastrIc InflammatIon? An orIgInal study and revIew of the lIterature. Acta Clin Croat. 2019;58(4):576–82. https://doi.org/10.20471/acc.2019.58.04.02.CrossRefPubMedPubMedCentral

19.

Sevencan NO, Cesur O, Cakar M, Dogan E, Ozkan AE, Benli AR. Mean platelet volume and red cell distribution width as potential new biomarkers in children with gastroesophageal reflux disease. Am J Transl Res. 2019;11(5):3176–86.PubMedPubMedCentral

20.

Turk OOZ, Badak B, Bal A. Evaluation of mean platelet volume as a predictor of gastric disorders. Arch Clin Exp Surg. 2015;4(5):216–21.

21.

Deal L, Gold BD, Gremse DA, Winter HS, Peters SB, Fraga PD, et al. Age-specific questionnaires distinguish GERD symptom frequency and severity in infants and young children: development and initial validation. J Pediatr Gastroenterol Nutr. 2005;41(2):178–85.CrossRefPubMed

22.

Tsou VM, Baker R, Book L, Hammo A‑H, Soffer EF, Wang W, et al. Multicenter, randomized, double-blind study comparing 20 and 40 mg of pantoprazole for symptom relief in adolescents (12 to 16 years of age) with gastroesophageal reflux disease (GERD). Clin Pediatr. 2006;45(8):741–9.CrossRef

23.

Hajian-Tilaki K. Sample size estimation in diagnostic test studies of biomedical informatics. J Biomed Inform. 2014;48:193–204.CrossRefPubMed

24.

Haghi AR, Pourmohammad P, Rabiee MAS. Accuracy of mean platelet volume (MPV) and red cell distribution width (RDW) for the diagnosis of acute appendicitis: evaluation of possible new biomarkers. Adv J Emerg Med. 2020;4(2).

25.

Malekzadeh R, Razjouyan H, Nouraei S, Alimohammadi S, Mamarabadi M, Vahedi H, et al. Assessment of inter-and intra-observer variability of the la classification for gerd. Govaresh. 2006;11(1):27–32.

26.

Mwafy SN, Afana WM. Hematological parameters, serum iron and vitamin B 12 levels in hospitalized palestinian adult patients infected with Helicobacter pylori: a case-control study. Hematol Transfus Cell Ther. 2018;40:160–5.CrossRefPubMedPubMedCentral

27.

Li T, Huang A, Zhang M, Lan F, Zhou D, Wei H, et al. Increased red blood cell volume distribution width: important clinical implications in predicting gastric diseases. Clin Lab. 2017;63:1199–206.CrossRefPubMed

28.

Kalkan Ç, Soykan I. Utility of a laboratory score in the prediction of gastric emptying in autoimmune gastritis patients. Acta Clin Belg. 2018;73(1):75–9.CrossRefPubMed

29.

Gana JC, Turner D, Mieli-Vergani G, Davenport M, Miloh T, Avitzur Y, et al. A clinical prediction rule and platelet count predict esophageal varices in children. Gastroenterology. 2011;141(6):2009–16.CrossRefPubMed

30.

Adami MR, Kieling CO, Schwengber FP, Hirakata VN, Vieira SMG. Noninvasive methods of predicting large esophageal varices in children with intrahepatic portal hypertension. J Pediatr Gastroenterol Nutr. 2018;66(3):442–6.CrossRefPubMed

31.

Qamar AA, Grace ND, Groszmann RJ, Garcia-Tsao G, Bosch J, Burroughs AK, et al. Platelet count is not a predictor of the presence or development of gastroesophageal varices in cirrhosis. Hepatology. 2008;47(1):153–9.CrossRefPubMed

32.

Uysal P, Tuncel T, Olmez D, Babayigit A, Karaman O, Uzuner N. The role of mean platelet volume predicting acute exacerbations of cystic fibrosis in children. Ann Thorac Med. 2011;6(4):227.CrossRefPubMedPubMedCentral

33.

Kaya MN, Yıldız A. The relationship between ulcerative colitis activity and vitamin D, mean platelet volume and platelet distribution width. Anatol Curr Med J. 2022;.

34.

Dooki ME, Nezhadan M, Mehrabani S, Osia S, Hadipoor A, Hajiahmadi M, et al. Diagnostic accuracy of laboratory markers for diagnosis of acute appendicitis in children. Wien Med Wochenschr. 2022;172(13–14):303–7.CrossRefPubMed

35.

Zagorskiĭ S, Korzhik AV, Tiu F, Pechkovskaia EV. Epidemiological aspects of gastroesophageal reflux disease in children in the conditions of large industrial city. Eksp Klin Gastroenterol. 2013;5:17–22.

36.

Yang A, Kang B, Choe JY, Kim HS, Kim K, Choe YH. Prevalence and epidemiological characteristics of endoscopically proven reflux esophagitis in children in Korea. Pediatr Gastroenterol Hepatol Nutr. 2017;20(3):160–6.CrossRefPubMedPubMedCentral

Titel: Value of mean platelet volume for diagnosing esophagitis in children with gastroesophageal reflux disease
verfasst von: Azin Gouran, MD
Prof. Mohammadreza Esmaeili dooki, MD
Assistant Professor Hossein-Ali Nikbakht
Associate Professor Hassan Mahmoodi, MD
Mohammad Pornasrolah, PhD
Maryam Nikpour, PhD
Associate Professor Sanaz Mehrabani, MD
Publikationsdatum: 18.11.2024
Verlag: Springer Vienna
Erschienen in: Wiener Medizinische Wochenschrift
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI: https://doi.org/10.1007/s10354-024-01062-8