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Erschienen in: European Surgery 5/2019

11.04.2019 | original article

Usefulness of the holistic context of frailty as a prognostic factor for the outcome of geriatric patients undergoing emergency abdominal surgery

verfasst von: Fernando Fuertes-Guiró, MD, PhD, Eduardo Vitali-Erion, MD, Amalia Rodriguez Fernandez, MD

Erschienen in: European Surgery | Ausgabe 5/2019

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Summary

Background

This study aims to assess frailty in a holistic context as a prognostic factor for the outcomes of a group of geriatric patients undergoing emergency abdominal surgery, identifying the predictors that could be included in a global assessment score of preoperative frailty.

Methods

Four groups of predictors (physical, cognitive, functional, and social) were evaluated in a group of patients selected for abdominal surgery during the preoperative period. The outcomes for three groups of variables (mortality, morbidity, and use of health resources) were measured using multivariate logistic regression when the response variable is categorical, and the multiple linear regression model for continuous numeric response variables.

Results

In the period studied, 286 patients aged 65 years or older required an emergency procedure. Physical/phenotypic predictors are consequently related to outcomes of morbidity and mortality and the use of resources, while predictors of mortality and socioeconomic factors predominate in functional and cognitive outcomes. Individually, Mini Nutritional Assessment (short form), sarcopenia, Pfeiffer, Barthel, and Duke tests best predict outcomes after emergency surgery.

Conclusion

Frailty is a predictive factor that should be routinely used in emergency geriatric surgery in a holistic context that includes physical, cognitive, functional, and social variables. Designing scores based on a broader concept of frailty will enable a more consistent predictive evaluation. Social frailty may have an important predictive value in the postoperative hospital outcome and in other medical fields, and should be studied in more depth in the future.
Literatur
1.
Zurück zum Zitat Fried LP, Hadley EC, Walston JD, Newman AB, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ. 2005;2005(31):e24.CrossRef Fried LP, Hadley EC, Walston JD, Newman AB, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ. 2005;2005(31):e24.CrossRef
2.
Zurück zum Zitat Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62(7):738–43.CrossRefPubMed Rockwood K, Andrew M, Mitnitski A. A comparison of two approaches to measuring frailty in elderly people. J Gerontol A Biol Sci Med Sci. 2007;62(7):738–43.CrossRefPubMed
4.
Zurück zum Zitat Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed Clegg A, Young J, Iliffe S, Rikkert MO, Rockwood K. Frailty in elderly people. Lancet. 2013;381(9868):752–62.CrossRefPubMed
5.
Zurück zum Zitat Walker JD. Aging and frailty in first nations communities. First nations information governance centre. Can J Aging. 2017;3:1–12. Walker JD. Aging and frailty in first nations communities. First nations information governance centre. Can J Aging. 2017;3:1–12.
6.
Zurück zum Zitat Rockwood K, Hogan DB, MacKnight C. Conceptualisation and measurement of frailty in elderly people. Drugs Aging. 2000;17(4):295–302.CrossRefPubMed Rockwood K, Hogan DB, MacKnight C. Conceptualisation and measurement of frailty in elderly people. Drugs Aging. 2000;17(4):295–302.CrossRefPubMed
7.
Zurück zum Zitat Shears M, McGolrick D, Waters B, Jakab M, Boyd JG, Muscedere J. Frailty measurement and outcomes in interventional studies: protocol for a systematic review of randomised control trials. BMJ Open. 2017;7(12):e18872.CrossRefPubMedPubMedCentral Shears M, McGolrick D, Waters B, Jakab M, Boyd JG, Muscedere J. Frailty measurement and outcomes in interventional studies: protocol for a systematic review of randomised control trials. BMJ Open. 2017;7(12):e18872.CrossRefPubMedPubMedCentral
8.
Zurück zum Zitat Torrance ADW, Powell SL, Griffiths EA. Emergency surgery in the elderly: challenges and solutions. Open Access Emerg Med. 2015;7:55–68.PubMedPubMedCentral Torrance ADW, Powell SL, Griffiths EA. Emergency surgery in the elderly: challenges and solutions. Open Access Emerg Med. 2015;7:55–68.PubMedPubMedCentral
9.
Zurück zum Zitat Søreide K, Desserud KF. Emergency surgery in the elderly: the balance between function, frailty, fatality and futility. Scand J Trauma Resusc Emerg Med. 2015;23:10.CrossRefPubMedPubMedCentral Søreide K, Desserud KF. Emergency surgery in the elderly: the balance between function, frailty, fatality and futility. Scand J Trauma Resusc Emerg Med. 2015;23:10.CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short form mini nutritional assessment (MNA-SF). J Gerontol. 2001;56A:M366–M77.CrossRef Rubenstein LZ, Harker JO, Salvà A, Guigoz Y, Vellas B. Screening for undernutrition in geriatric practice: developing the short form mini nutritional assessment (MNA-SF). J Gerontol. 2001;56A:M366–M77.CrossRef
11.
Zurück zum Zitat Rubbieri G, Mossello E, Di Bari M. Techniques for the diagnosis of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):181–4.PubMedPubMedCentral Rubbieri G, Mossello E, Di Bari M. Techniques for the diagnosis of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):181–4.PubMedPubMedCentral
12.
Zurück zum Zitat Broadhead WE, Gehlbach SH, de Gruy FV, Kaplan BH. The duke-UNC functional social support questionnaire. Measurement of social support in family medicine patients. Med Care. 1988;26(7):709–23.CrossRefPubMed Broadhead WE, Gehlbach SH, de Gruy FV, Kaplan BH. The duke-UNC functional social support questionnaire. Measurement of social support in family medicine patients. Med Care. 1988;26(7):709–23.CrossRefPubMed
13.
Zurück zum Zitat Agostini JV, Inouye SK. Delirium. In: Hazzard WR, Blass JP, Halter JB, Ouslander JG, Tinetti ME, editors. Principles of geriatric medicine and gerontology. 5th ed. New York: McGraw-Hill; 2003. pp. 1503–15. Agostini JV, Inouye SK. Delirium. In: Hazzard WR, Blass JP, Halter JB, Ouslander JG, Tinetti ME, editors. Principles of geriatric medicine and gerontology. 5th ed. New York: McGraw-Hill; 2003. pp. 1503–15.
15.
Zurück zum Zitat Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818–29.CrossRef Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13(10):818–29.CrossRef
16.
Zurück zum Zitat Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, Takenaga R, Devgan L, Holzmueller CG, Tian J, Fried LP. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210(6):901–8.CrossRefPubMed Makary MA, Segev DL, Pronovost PJ, Syin D, Bandeen-Roche K, Patel P, Takenaga R, Devgan L, Holzmueller CG, Tian J, Fried LP. Frailty as a predictor of surgical outcomes in older patients. J Am Coll Surg. 2010;210(6):901–8.CrossRefPubMed
17.
Zurück zum Zitat Robinson TN, Wu DS, Pointer L, Dunn CL, Cleveland JC Jr, Moss M. Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg. 2013;206(4):544–50.CrossRefPubMedPubMedCentral Robinson TN, Wu DS, Pointer L, Dunn CL, Cleveland JC Jr, Moss M. Simple frailty score predicts postoperative complications across surgical specialties. Am J Surg. 2013;206(4):544–50.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Mosquera C, Spaniolas K, Fitzgerald TL. Impact of frailty on surgical outcomes: the right patient for the right procedure. Surgery. 2016;160(2):272–80.CrossRefPubMed Mosquera C, Spaniolas K, Fitzgerald TL. Impact of frailty on surgical outcomes: the right patient for the right procedure. Surgery. 2016;160(2):272–80.CrossRefPubMed
19.
Zurück zum Zitat Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7.CrossRefPubMedPubMedCentral Morley JE, Vellas B, van Kan GA, Anker SD, Bauer JM, Bernabei R, Cesari M, Chumlea WC, Doehner W, Evans J, Fried LP, Guralnik JM, Katz PR, Malmstrom TK, McCarter RJ, Gutierrez Robledo LM, Rockwood K, von Haehling S, Vandewoude MF, Walston J. Frailty consensus: a call to action. J Am Med Dir Assoc. 2013;14(6):392–7.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.CrossRefPubMedPubMedCentral Lin HS, Watts JN, Peel NM, Hubbard RE. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Orouji Jokar T, Ibraheem K, Rhee P, Kulavatunyou N, Haider A, Phelan HA, Fain M, Mohler MJ, Joseph B. Emergency general surgery specific frailty index: a validation study. J Trauma Acute Care Surg. 2016;81(2):254–60.CrossRefPubMed Orouji Jokar T, Ibraheem K, Rhee P, Kulavatunyou N, Haider A, Phelan HA, Fain M, Mohler MJ, Joseph B. Emergency general surgery specific frailty index: a validation study. J Trauma Acute Care Surg. 2016;81(2):254–60.CrossRefPubMed
22.
Zurück zum Zitat Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH, Kennedy M, Hurria A. Frailty for surgeons: review of a national institute on aging conference on frailty for specialists. J Am Coll Surg. 2015;221(6):1083–92.CrossRefPubMedPubMedCentral Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH, Kennedy M, Hurria A. Frailty for surgeons: review of a national institute on aging conference on frailty for specialists. J Am Coll Surg. 2015;221(6):1083–92.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Judith SL, Danielle P, Jugdeep H, Dhesi K. Frailty in the older surgical patient: a review. Age Ageing. 2012;41(2):142–7.CrossRef Judith SL, Danielle P, Jugdeep H, Dhesi K. Frailty in the older surgical patient: a review. Age Ageing. 2012;41(2):142–7.CrossRef
24.
Zurück zum Zitat Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. Tools in the assessment of sarcopenia. Calcif Tissue Int. 2013;93(3):201–10.CrossRefPubMedPubMedCentral Cooper C, Fielding R, Visser M, van Loon LJ, Rolland Y, Orwoll E, Reid K, Boonen S, Dere W, Epstein S, Mitlak B, Tsouderos Y, Sayer AA, Rizzoli R, Reginster JY, Kanis JA. Tools in the assessment of sarcopenia. Calcif Tissue Int. 2013;93(3):201–10.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Quinn TJ, McArthur K, Ellis G, Stott DJ. Functional assessment in older people. BMJ. 2011;343:d4681.CrossRefPubMed Quinn TJ, McArthur K, Ellis G, Stott DJ. Functional assessment in older people. BMJ. 2011;343:d4681.CrossRefPubMed
26.
Zurück zum Zitat Villarejo A, Puertas-Martín V. Usefulness of short tests in dementia screening. Neurologia. 2011;26(7):425–33.CrossRefPubMed Villarejo A, Puertas-Martín V. Usefulness of short tests in dementia screening. Neurologia. 2011;26(7):425–33.CrossRefPubMed
27.
Zurück zum Zitat Mc Dowell I. Measuring health: a guide to rating scales and questionnaires. 3rd ed. Oxford: Oxford University Press; 2006. pp. 150–203.CrossRef Mc Dowell I. Measuring health: a guide to rating scales and questionnaires. 3rd ed. Oxford: Oxford University Press; 2006. pp. 150–203.CrossRef
28.
Zurück zum Zitat Marufu TC, ManningsIain A, Moppett K. Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review. Injury. 2015;46(12):2325–34.CrossRefPubMed Marufu TC, ManningsIain A, Moppett K. Risk scoring models for predicting peri-operative morbidity and mortality in people with fragility hip fractures: Qualitative systematic review. Injury. 2015;46(12):2325–34.CrossRefPubMed
29.
Zurück zum Zitat Schmidta M, Eckardtb R, Altmeppena S, Werneckec KD, Spiesa C. Functional impairment prior to major non-cardiac surgery is associated with mortality within one year in elderly patients with gastrointestinal, gynaecological and urogenital cancer: A prospective observational cohort study. J Geriatr Oncol. 2018;9(1):53–9.CrossRef Schmidta M, Eckardtb R, Altmeppena S, Werneckec KD, Spiesa C. Functional impairment prior to major non-cardiac surgery is associated with mortality within one year in elderly patients with gastrointestinal, gynaecological and urogenital cancer: A prospective observational cohort study. J Geriatr Oncol. 2018;9(1):53–9.CrossRef
31.
Zurück zum Zitat Vetrano DL, Landi F, De Buyser SL, Carfì A, Zuccalà G, Petrovic M, Volpato S, Cherubini A, Corsonello A, Bernabei R, Onder G. Predictors of length of hospital stay among older adults admitted to acute care wards: a multicentre observational study. Eur J Intern Med. 2014;25(1):56–62.CrossRefPubMed Vetrano DL, Landi F, De Buyser SL, Carfì A, Zuccalà G, Petrovic M, Volpato S, Cherubini A, Corsonello A, Bernabei R, Onder G. Predictors of length of hospital stay among older adults admitted to acute care wards: a multicentre observational study. Eur J Intern Med. 2014;25(1):56–62.CrossRefPubMed
32.
Zurück zum Zitat Agboado G, Peters J, Donkin L. Factors influencing the length of hospital stay among patients resident in blackpool admitted with COPD: a cross-sectional study. BMJ Open. 2012;2(5):e869.CrossRefPubMedPubMedCentral Agboado G, Peters J, Donkin L. Factors influencing the length of hospital stay among patients resident in blackpool admitted with COPD: a cross-sectional study. BMJ Open. 2012;2(5):e869.CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Bo M, Fonte G, Pivaro F, Bonetto M, Comi C, Giorgis V, Marchese L, Isaia G, Maggiani G, Furno E, Falcone Y, Isaia GC. Prevalence of and factors associated with prolonged length of stay in older hospitalized medical patients. Geriatr Gerontol Int. 2016;16(3):314–21.CrossRefPubMed Bo M, Fonte G, Pivaro F, Bonetto M, Comi C, Giorgis V, Marchese L, Isaia G, Maggiani G, Furno E, Falcone Y, Isaia GC. Prevalence of and factors associated with prolonged length of stay in older hospitalized medical patients. Geriatr Gerontol Int. 2016;16(3):314–21.CrossRefPubMed
Metadaten
Titel
Usefulness of the holistic context of frailty as a prognostic factor for the outcome of geriatric patients undergoing emergency abdominal surgery
verfasst von
Fernando Fuertes-Guiró, MD, PhD
Eduardo Vitali-Erion, MD
Amalia Rodriguez Fernandez, MD
Publikationsdatum
11.04.2019
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 5/2019
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-019-0580-2

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