Overall survival of patients suffering from upper gastrointestinal (GI) cancer is still poor. Most of the patients are diagnosed in advanced stages. But even in patients with operable disease, the recurrence rates, especially of gastric and pancreatic neoplasias, are still very high. Much effort has therefore been put in the development of palliative and curative therapeutic concepts. The aim of this article is to summarize the most important publications presented at American Society of Clinical Oncology (ASCO) 2013 concerning gastric and pancreatic cancer with the main focus on relevance for clinical practice.