This article reports the development of low grade endophthalmitis following Nd:YAG laser posterior capsulotomy. The patient previously underwent uncomplicated extracapsular cataract extraction with intraocular lens (IOL) insertion and was free of inflammation prior to laser capsulotomy. Anterior vitrectomy with partial capsular bag removal and anterior chamber washout were performed. Samples for cultures were taken and intravitreal antibiotics injected. The patient was managed with topical and systemic antibiotics and steroids. Complete resolution of the inflammation with return of vision to 20/25 was achieved without removal of the intraocular lens or lenticular remnants. The endophthalmitis was responsive to a minimally invasive intervention as well as medicinal therapy including antibiotic agents, and it resolved without any invasive surgical intervention, such as total capsulectomy, IOL exchange or removal and posterior vitrectomy.