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01.11.2013 | original article | Ausgabe 21-22/2013

Wiener klinische Wochenschrift 21-22/2013

Transperineal template-guided biopsy for diagnosis of prostate cancer in patients with at least two prior negative biopsies

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 21-22/2013
Autoren:
Tobias Klatte, Natalia Swietek, Georg Schatzl, FEBU Ass.-Prof. Dr. Matthias Waldert

Summary

Objective

To evaluate the prostate cancer (PCa) detection rate, PCa location, PCa significance and complications of a standardized 24-core template-guided transperineal biopsy (TPB) approach in patients with at least two negative transrectal biopsies.

Methods

We prospectively recruited 50 men who had at least two negative transrectal ultrasound-guided extended biopsies in the past 24 months, a prostate-specific antigen (PSA) < 20 ng/mL, a prostate volume < 100 mL, and life expectancy of at least 90 % at 10 years. All patients underwent a standardized 24-core template-guided TPB biopsy. The PCa detection rate, PCa location, PCa significance, and complications were recorded.

Results

Median age was 57.5 years and the median PSA level was 7.3 ng/ml. PCa was detected in 24 patients (48 %). The anterior zone was involved in 16 (32 %) PCa. Six PCa (25 %) were insignificant. Biopsy related complications occurred in 2 patients (4 %).

Conclusions

A 24-core TPB is a safe procedure with a high PCa detection rate. Few of the detected PCa are clinically insignificant. Men with at least two negative transrectal biopsies may be counseled to undergo TPB.

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