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01.08.2013 | Review

Tissue engineering of vascular grafts

verfasst von: H. Bergmeister, MD, DVM, M. Strobl, MD, Dipl.-Ing.(FH) C. Grasl, Ao.Univ. Prof. Dipl.-Ing. Dr.techn. R. Liska, Ao.Univ. Prof. Dipl.-Ing. Dr. H. Schima

Erschienen in: European Surgery | Ausgabe 4/2013

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Summary

Background

There is a considerable clinical need for a sufficient prosthetic small-diameter substitute which can compete with autologous vessels. Currently used synthetic materials have a poor performance due to high thrombogeneicity and development of intimal hyperplasia. Tissue engineering is an interesting alternative approach for vascular graft fabrication.

Methods

We briefly overviewed the development of tissue-engineered vascular substitutes including endothelialized biohybrid grafts, collagen and fibrin-based scaffolds, decellularized scaffolds, cell self-assembly approaches, and biodegradable constructs based on synthetic polymers.

Results

Significant advances have been made over the past decades in the development of tissue-engineered conduits. Biomechanical weakness, one of the major limitations of biologically based grafts has been resolved and two tissue-engineered grafts are currently under further investigation for clinical application.

Conclusions

Vascular tissue engineering is a promising approach to overcome the limitations of current therapies in small-diameter vascular replacement.

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Xue L, Greisler HP. Biomaterials in the development and future of vascular grafts. J Vas Surg. 2003;37:472–80.CrossRef

Kakisis JD, Liapis CD, Breuer C, Sumpio BE. Artificial blood vessel: the holy grail of peripheral vascular surgery. J Vasc Surg. 2005;41:349–54.PubMedCrossRef

Wang X, Lin P, Yao Q, Chen C. Development of small-diameter vascular grafts. World J Surg. 2007;31:682–9.PubMedCrossRef

Venkatraman S, Boey F, Lao LL. Implanted cardiovascular polymers: natural, synthetic and bio-inspired. Prog Polym Sci. 2008;33:853–74.CrossRef

Brewster DC. Prosthetic grafts. In: Rutherford RB, editor. Vascular surgery. 5th ed. Philadelphia: WB Saunders; 2000. pp 559–84.

Klinkert P, Post PN, Breslau PJ, van Bockel JH. Saphenous vein versus PTFE for above-knee femoropopliteal bypass. A review of the literature. Eur J Vasc Endovasc Surg. 2004;27:357–62.PubMedCrossRef

Weitz JI, Byrne J, Clagett P, Farkouh ME, Porter JM, Sackett DL, Strandness DE, Taylor LM. Diagnosis and treatment of chronic arterial insufficiency of the lower extremities: a critical review. Circulation. 1996;94:3026–49.PubMedCrossRef

Loh SA, Howell BS, Rockman CB, Cayne NS, Adelman MA, Gulkarov I, Veith FJ, Maldonado TS. Ann Mid- and long-term results of the treatment of infrainguinal arterial occlusive disease with precuffed expanded polytetrafluoroethylene grafts compared with vein grafts. Vasc Surg. 2013;27:208–17.CrossRef

Pereira CE, Albers M, Romiti M, Brochado-Neto FC, Pereira CA. Meta-analysis of femoropopliteal bypass grafts for lower extremity arterial insufficiency. J Vasc Surg. 2006;44:510–7.PubMedCrossRef

10.

de Mel A, Jell G, Stevens MM, Seifalian AM. Biofunctionalization of biomaterials for accelerated in situ endothelialization: a review. Biomacromolecules. 2008;9:2969–79.PubMedCrossRef

11.

Jordan SW, Chaikof EL. Novel thromboresistant materials. J Vasc Surg. 2007;45:104A–15A.CrossRef

12.

Zilla P, Bezuidenhout D, Human P. Prostheic vascular grafts: wrong models, wrong questions and no healing. Biomaterials. 2007;28:5009–27.PubMedCrossRef

13.

Kapadia MR, Popwich DA, Kibbe MR. Modified prosthetic vascular conduits. Circulation. 2008;117:1873–82.PubMedCrossRef

14.

Nerem RM, Seliktar D. Vascular tissue engineering. Annu Rev Eng. 2001;3:225–43.CrossRef

15.

Isenberg BC, Chrysanthi W, Tranquillo RT. Small-diameter artificial arteries engineered in vitro. Circ Res. 2006;98:25–35.PubMedCrossRef

16.

Ratcliffe A. Tissue engineering of vascular grafts. Matrix Biol. 2000;19:353–7.PubMedCrossRef

17.

L’Heraux N, Dusserre N, Garrido S, de la Fuente L, McAllister T. Technology insight: the evolution of tissue-engineered vascular grafts-from research to clinical practice. Nat Clin Pract Cardiovasc Med. 2007;4:389–95.CrossRef

18.

Herring MB. Endothelial cell seeding. J Vasc Surg. 1991;13:731–2.PubMedCrossRef

19.

Herring M, Smith J, Dalsing M, Glover J, Compton R, Etchberger K, Zollinger T. Endothelial seeding of polytetrafluoroethylene femoral popliteal bypasses: the failure of low-density seeding to improve patency. J Vasc Surg. 1994;20:650–5.PubMedCrossRef

20.

Pasic M, Müller-Glauser W, von Segesser LK, Lachat M, Mihaljevic T, Turina MI. Superior late patency of small-diamter dDacron grafts seeded with omental microvascular cells: an experimental study. Ann Thorac Surg. 1994;58:677–83.PubMedCrossRef

21.

Zilla P, Deutsch M, Meinhart J. Endothelial cell transplantation. Semin Vasc Surg. 1999;12:52–63.PubMed

22.

Zilla P, Fasol R, Deutsch M, Fischlein T, Minar E, Hammerle A, Krupicka O, Kadletz M, Meinhart J. Endothelial cell seeding of polytetrafluoroethylene vascular grafts in humans: a preliminary report. J Vasc Surg. 1987;6:535–22.PubMed

23.

Feugier P, Black RA, Hunt JA, How TV. Attachment, morphology and adherence of human endothelial cells to vascular prosthesis materials under the action of shear stress. Biomaterials. 2005;26:1457–66.PubMedCrossRef

24.

Baguneid M, Murray D, Salacinski HJ, Fuller B, Hamilton G, Walker M, Seifalian AM. Shear stress preconditioning and tissue-engineering-based paradigms for generating arterial substitutes. Biotechnol Appl Biochem. 2004;39:151–7.PubMedCrossRef

25.

Deutsch M, Meinhart J, Zilla P, Howanitz N, Gorlitzer M, Froeschl A, Stuempflen A, Bezidenhout D, Grabenwoeger M. Long-term experience in autologous in vitro endothelialisation of infrainguinal ePTFE grafts. J Vasc Surg. 2009;49:352–62.PubMedCrossRef

26.

Parikh SA, Edelman ER. Endothelial cell delivery for cardiovascular therapy. Adv Drug Deliv Rev. 2000;42:139–61.PubMedCrossRef

27.

Meinhart JG, Schense JC, Schima H, Gorlitzer M, Hubbel JA, Deutsch M, Zilla P. Enhanced endothelial cell retention on shear-stressed synthetic vascular grafts precoated with RGD-cross-linked fibrin. Tissue Eng. 2005;11:887–95.PubMedCrossRef

28.

Weinberg CB, Bell E. A blood vessel model constructed from collagen and cultured vascular cells. Science. 1986;231:397–400.PubMedCrossRef

29.

L’Heraux N, German L, Labbe R, Auger FA. In vitro construction of a human blood vessel from cultured vascular cells: a morphologic study. J Vasc Surg. 1993;17:499–509.

30.

Girton TS, Oegama TR, Grassl ED, Isenberg BC, Tranquillo RT. Mechanisms of stiffening and strengthening in media-equivalents fabricated using glycation. J Biomech Eng. 2000;122:216–23.PubMedCrossRef

31.

Swartz DD, Russel JA, Andreadis ST. Engineering of fibrin-based functional and implantable small-diameter blood vessels. Am J Physiol Heart Circ Physiol. 2005;288:1451–60.CrossRef

32.

Barocas VH, Girton TS, Tranquillo RT. Enginered alignment in media equivalents: magnetic prealignment and mandrel compaction. J Biomech Eng. 1998;120:660–6.PubMedCrossRef

33.

Syedain ZH, Meier LA, Bjork JW, Lee A, Tranquillo RT. Implantable arterial grafts from human fibroblasts and fibrin using a multi-graft pulsed flow-stretch bioreactor with noninvasive strength monitoring. Biomaterials. 2011;32:714–22.PubMedCrossRef

34.

Schmidt CE, Baier JM. Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering. Biomaterials. 2000;21:2215–31.PubMedCrossRef

35.

Wilson GJ, Courtman DW, Klement P, Lee JM, Yeger H. Acellular matrix: a biomaterials approach for coronary artery bypass and heart valve replacement. Ann Thorac Surg. 1995;60:353–8.CrossRef

36.

Ketchedjian A, Jones AL, Krueger P, Robinson E, Crouch K, Wolfinbarger L, Hopkins R. Recellularization of decellularized allograft scaffolds in ovine great vessel reconstructions. Ann Thorac Surg. 2005;79:888–96.PubMedCrossRef

37.

Mc Fetridge PS, Daniel JW, Bodamyali T, Horrocks M, Chaudhuri JB. Preparation of porcine carotid arteries for vascular tissue engineering applications. J Biomed Mater Res A. 2004;70:224–34.CrossRef

38.

Conklin BS, Wu H, Lin PH, Lumsden AB, Chen C. Basic fibroblast growth factor coating and endothelial cell seeding of a decellularized heparin-coated vascular graft. Artif Organs. 2004;28:668–75.PubMedCrossRef

39.

Kaushal S, Amiel GE, Guleserian KJ, Shapira OM, Perry T, Sutherland FW, Rabkin E, Moran AM, Schoen FJ, Atala A, Soker S, Bischoff J, Mayer JE. Functional small diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med. 2001;7:1035–40.PubMedCrossRef

40.

Andree B, Bär A, Haverich A, Hilfiker A. Small intestinal submucosa segments as matrix for tissue engineering: review. Tiss Eng Part B Rev. 2013 Jan 14;19(4):279–91.CrossRef

41.

Bergmeister H, Boeck P, Kasimir M, Fleck T, Fitzal F, Husinsky W, Mittlboeck M, Stoehr H, Losert U, Wolner E, Grabenwoeger M. Effect of laser perforation on the remodeling of acellular matrix grafts. J Biomed Mater Res B: Appl Biomater. 2005;74:495–503.

42.

Bergmeister H, Plasenzotti R, Walter I, Plass C, Bastian F, Rieder E, Sipos W, Kaider A, Losert U, Weigel G. Decellularized xenogeneic small-diameter arteries: transition from a muscular to an elastic phenotype in vivo. J Biomed Mater Res B Appl Biomater. 2008;87:95–104.PubMed

43.

L’Heraeux N, Paquet S, Lacoe R, Germain L, Auger FA. A completely biological tissue engineered human blood vessel. FASEB J. 1998;12:47–56.

44.

Peck M, Gebhart D, Dusserre N, McAllister T, L’Heraeux N. The evolution of vascular tissue engineering and current state of the art. Cells Tissues Organs. 2012;195:144–58.PubMedCrossRef

45.

Niklason LE, Gao J, Abbott WM, Hirschi KK, Houser S, Marini R, Langer R. Functional arteries grown in vitro. Science. 1999;284:489–93.PubMedCrossRef

46.

Shin’oka T, Imai Y, Ikada Y. Transplantation of tissue-engineered pulmonary artery. N Engl J Med. 2001;344:532–3.CrossRef

47.

Qint C, Arief M, Muto A, Dradik A, Niklason LE. Allogeneic human tissue-engineered blood vessel. J Vasc Surg. 2012;55:790–8.CrossRef

48.

Dahl SL, Blum JL, Niklason LE. Bioengineered vascular grafts: can we make them of off-the-shelf? Trends Cardiovasc Med. 2011;21:83–9.PubMedCrossRef

49.

Vasita R, Katti DS. Nanofibers and their applications in tissue engineering. Int J Nanomedicine. 2006;1:15–30.PubMedCrossRef

50.

Wu W, Allen RA, Wang Y. Fast-degrading elastomer enables rapid remodeling of a cell-free synthetic graft into a neoartery. Nat Med. 2012;18:1148–53.PubMedCrossRef

51.

De Valence S, Tille JC, Mugnal D, Mrowczynski W, Gurny R, Möller M, Walpoth BH. Long term performance of polycaprolactone vascular grafts in a rat abdominal aorta replacement model. Biomaterials. 2012;33:38–47.PubMedCrossRef

52.

Pham QP, Sharma U, Mikos AG. Electrospinning of polymeric nanofibers for tissue engineering applications: a review. Tissue Eng. 2006;12:1197–211.PubMedCrossRef

53.

Prabhakaran MP, Ghasemi-Mobarakeh L, Ramakrishna S. Electrospun composite nanofibers for tissue engineering regeneration. J Nanosci Nanotechnol. 2011;11:3039–57.PubMedCrossRef

54.

Kong X, Han B, Li H, Liang Y, Shao K, Liu W. New biodegradable small-diameter artificial vascular prosthesis: a feasibility study. J Biomed Mater Res Part A. 2012;100A:1494–1504.CrossRef

55.

Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B. Electrospun cellular microenvironments: understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2011;63:209–20.PubMedCrossRef

56.

Sill TJ, von Recum HA. Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008;29:1989–2006.PubMedCrossRef

57.

Sell SA, McClure MJ, Barnes CP, Knapp DC, Walpoth BH, Simpson DG, Bowlin GL. Electrospun polydioxanone-elastin blends: potential for bioresorbable vascular grafts. Biomed Mater. 2006;1:72–80.PubMedCrossRef

58.

Grasl C, Bergmeister H, Stoiber M, Schima H, Weigel G. Electrospun polyurethane vascular grafts: in vitro mechanical behaviour and endothelial adhesion molecule expression. J Biomed Mater Res A. 2010;93:716–23.PubMed

59.

Bergmeister H, Schreiber C, Grasl C, Walter I, Plasenzotti R, Stoiber M, Bernhard D, Schima H. Healing characteristics of electrospun polyurethane grafts with various porosities. Acta Biomater. 2013;9:6032–40.PubMedCrossRef

60.

Bergmeister H, Grasl C, Walter I, Plasenzotti R, Stoiber M, Losert U, Weigel G, Schima H. Electrospun small-diameter polyurethane vascular grafts: ingrowth and differentiation of vascular specific host cells. Artif Organs. 2012;36:54–61.PubMedCrossRef

61.

Baudis S, Ligon SC, Seidler K, Weigel G, Grasl C, Bergmeister H, Schima H, Liska R. Hard-block degradable thermoplastic urethane-elastomers for electrospun vascular prostheses. J Polym Sci Part A: Polym Chem. 2012;50:1272–80.CrossRef

62.

Bergmeister H, Baudis S, Grasl C, Stoiber M, Schreiber C, Walter I, Plasenzotti R, Liska R, Schima H. In vivo evaluation of electrospun, biodegradable and non-degradable elastomeric vascular grafts. Int J Art Organs. 2011;34:641.

Titel: Tissue engineering of vascular grafts
verfasst von: H. Bergmeister, MD, DVM
M. Strobl, MD
Dipl.-Ing.(FH) C. Grasl
Ao.Univ. Prof. Dipl.-Ing. Dr.techn. R. Liska
Ao.Univ. Prof. Dipl.-Ing. Dr. H. Schima
Publikationsdatum: 01.08.2013
Verlag: Springer Vienna
Erschienen in: European Surgery / Ausgabe 4/2013
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI: https://doi.org/10.1007/s10353-013-0224-x

Springer Medizin Österreich

Summary

Background

Methods

Results

Conclusions

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