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Erschienen in: Wiener klinische Wochenschrift 23-24/2014

01.12.2014 | original article

Thoracic periaortic adipose tissue in relation to cardiovascular risk in type 2 diabetes mellitus

verfasst von: Asst. Prof. Ömer Akyürek, MD, Asst. Prof. Duran Efe, MD, Asst. Prof. Zeynettin Kaya, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 23-24/2014

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Summary

Objective

To evaluate thoracic periaortic adipose tissue (TAT) burden in patients with type 2 diabetes mellitus (DM) in comparison with controls and in relation to cardiovascular risk factors.

Methods

A total of 93 patients with type 2 DM (mean (standard deviation; SD) age: 56.7 (11.2) years, 71.0 % were men) and 85 nondiabetic control subjects (mean (SD) age: 54.6 (10.9) years, 58.8 % were men) who were admitted to Mevlana University hospital between January 2011 and June 2013 and underwent multidetector computed tomography for any reason were included in this retrospective cohort study. Patient and control groups were compared in terms of demographic characteristics, anthropometrics, and laboratory findings. TAT volume was evaluated in both groups, while correlates of TAT were determined via linear regression analysis among patients.

Results

In patients with type 2 DM, TAT volume (40.1 (23.9) versus 16.9 (7.7) cm3, p < 0.001), fasting blood glucose (p < 0.001), total cholesterol (p < 0.001), triglyceride (p = 0.017), and low-density lipoprotein (LDL) cholesterol (p = 0.034) levels were significantly higher compared with the control group. Strong positive correlation of TAT was noted with body mass index (r = 0.339, p = 0.001) and serum levels for fasting blood glucose (r = 0.343, p < 0.001), hemoglobin A1c (HbA1c; r = 0.615, p < 0.001), total cholesterol (r = 0.269, p = 0.009), and LDL cholesterol (r = 0.258, p = 0.013). In stepwise regression analysis, Hba1c emerged as a significant predictor of TAT (b = 0.610, p < 0.001), contributing to 19 % of its variability.

Conclusion

In conclusion, our findings indicate significantly higher values for TAT in diabetics than controls, being associated positively with body weight, poor glycemic control, and dyslipidemia and strongly predicted by HbA1c levels in diabetic patients, while not differing with respect to gender, smoking status, and concomitant hypertension.
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Metadaten
Titel
Thoracic periaortic adipose tissue in relation to cardiovascular risk in type 2 diabetes mellitus
verfasst von
Asst. Prof. Ömer Akyürek, MD
Asst. Prof. Duran Efe, MD
Asst. Prof. Zeynettin Kaya, MD
Publikationsdatum
01.12.2014
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 23-24/2014
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-014-0611-8

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