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01.03.2023 | Gastroenterologie

Therapieupdate 2022: Colitis ulcerosa

verfasst von: Prof. Dr. Jörg C. Hoffmann, Dr. Jörg Edelmann

Erschienen in: Wiener klinisches Magazin | Ausgabe 2/2023

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Zusammenfassung

Mit über 300.000 Betroffenen in Deutschland und Kosten von über 10 Mrd. €/Jahr stellt die Colitis ulcerosa eine wichtige Erkrankung dar. Therapieziele sind klinische Remission, Verhinderung struktureller Schäden (mukosale und histologische Heilung) und gute Lebensqualität. Dazu ist eine Stratifizierung anhand von Risikofaktoren (junges Erkrankungsalter, tiefe Ulzera, Pankolitis, Mangelernährung und Therapierefraktärität) sinnvoll. Treten im Verlauf refraktäre Schübe auf, müssen Infektionen, besonders durch Zytomegalievirus (CMV) und Clostridien, ausgeschlossen werden. Neben Steroiden (nur im Schub) kommen Aminosalizylate zum Einsatz, Thiopurine in der Remissionserhaltung. Zusätzlich zu Antikörpern gegen Tumornekrosefaktor(TNF)-α (Infliximab) stehen Vedolizumab und Ustekinumab als Biologika zur Verfügung. Neue Alternativen sind Januskinaseinhibitoren (Tofacitinib, Filgotinib, Upadacitinib) sowie der Sphingosin-1-Phosphat-Modulator Ozanimod. Kontraindikationen und das jeweilige Nebenwirkungsprofile müssen beachtet werden.

Vorheriger Artikel Arzneimittelwechselwirkungen – wie kann man sich vor der Informationsflut schützen?

Nächster Artikel Molekularpathologisch determinierte multimodale Therapie gastrointestinaler Stromatumoren

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Titel: Therapieupdate 2022: Colitis ulcerosa
verfasst von: Prof. Dr. Jörg C. Hoffmann
Dr. Jörg Edelmann
Publikationsdatum: 01.03.2023
Verlag: Springer Vienna
Erschienen in: Wiener klinisches Magazin / Ausgabe 2/2023
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI: https://doi.org/10.1007/s00740-023-00484-1

Molekularpathologisch determinierte multimodale Therapie gastrointestinaler Stromatumoren

Onkologie

Reaktive Lymphadenopathien

Hämatologie

Panorama

Panorama

Ein neuer Mitspieler in der Kommunikation

Editorial

Arzneimittelwechselwirkungen – wie kann man sich vor der Informationsflut schützen?

Pharmakologie und Toxikologie
Übersichtsartikel

Springer Medizin Österreich

Therapieupdate 2022: Colitis ulcerosa

Zusammenfassung

Weitere Artikel der Ausgabe 2/2023

Molekularpathologisch determinierte multimodale Therapie gastrointestinaler Stromatumoren

Reaktive Lymphadenopathien

Panorama

Ein neuer Mitspieler in der Kommunikation

Arzneimittelwechselwirkungen – wie kann man sich vor der Informationsflut schützen?

Springer Medizin Österreich

Zusammenfassung

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Molekularpathologisch determinierte multimodale Therapie gastrointestinaler Stromatumoren

Reaktive Lymphadenopathien

Panorama

Ein neuer Mitspieler in der Kommunikation

Arzneimittelwechselwirkungen – wie kann man sich vor der Informationsflut schützen?