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Therapies in flux: highlights of the 2019 San Antonio Breast Cancer Symposium (SABCS)

verfasst von: Simon Peter Gampenrieder

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2020

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The San Antonio Breast Cancer Symposium (SABCS) in Texas, USA, is an annual highlight for breast cancer researchers from all over the world. Nearly every year, practice-changing clinical trials or meta-analyses are presented at this focused international meeting. In addition to these large studies, the meeting distinguishes itself by excellent scientific and educational sessions as well as a large poster session displaying the many-sided facets of breast cancer over five consecutive days. …

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Murthy R, et al. Abstract GS1-01: Tucatinib vs placebo, both combined with capecitabine and trastuzumab, for patients with pretreated HER2-positive metastatic breast cancer with and without brain metastases (HER2CLIMB). Cancer Res. 2020;80(4 Supplement):GS1–01.

Krop IE, et al. Abstract GS1-03: [Fam-] trastuzumab deruxtecan (T-DXd; DS-8201a) in subjects with HER2-positive metastatic breast cancer previously treated with T‑DM1: A phase 2, multicenter, open-label study (DESTINY-Breast01). Cancer Res. 2020;80(4 Supplement):GS1–03.

Schmid P, et al. Abstract GS3-03: KEYNOTE-522 study of neoadjuvant pembrolizumab + chemotherapy vs placebo + chemotherapy, followed by adjuvant pembrolizumab vs placebo for early triple-negative breast cancer: pathologic complete response in key subgroups and by treatment exposure, residual cancer burden, and breast-conserving surgery. Cancer Res. 2020;80(4 Supplement):GS3–03.

Sestak I, et al. Abstract GS4-03: Validation of the clinical treatment score post 5 years (CTS5) in women with hormone receptor positive, HER2-negative, node-negative disease from the TAILORx study. Cancer Res. 2020;80(4 Supplement):GS4–03.

Li J, et al. Abstract GS1-08: Adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for triple-negative breast cancer (cbcsg010): An open-label, randomised, multicentre, phase 3 trial. Cancer Res. 2020;80(4 Supplement):GS1–08.

van Mackelenbergh M, et al. Abstract GS1-07: Effects of capecitabine as part of neo-/adjuvant chemotherapy. A meta-analysis of individual patient data from 12 randomized trials including 15,457 patients. Cancer Res. 2020;80(4 Supplement):GS1–07.

Cuzick J, et al. Abstract GS4-04: Ten year results of the international breast cancer intervention study II. Cancer Res. 2020;80(4 Supplement):GS4–04.

De Censi A. Abstract ES3-3: Low dose tamoxifen and other approaches to improve chemoprevention uptake. Cancer Res. 2020;80(4 Supplement):ES3–3.

Heil J, et al. Abstract GS5-03: Diagnosing residual disease and pathologic complete response after neoadjuvant chemotherapy in breast cancer patients by image-guided vacuum-assisted breast biopsy: Results of a prospective multicenter trial. Cancer Res. 2020;80(4 Supplement):GS5–03.

10.

Tasoulis MK, et al. Abstract GS5-04: Accuracy of post-neoadjuvant chemotherapy image-guided breast biopsy to predict the presence of residual cancer: A multi-institutional pooled analysis. Cancer Res. 2020;80(4 Supplement):GS5–04.

11.

Peeters M‑JTFDV, et al. Abstract GS5-06: Towards omitting breast surgery in patients with a pathologic complete response after neoadjuvant systemic treatment: interim analysis of the MICRA trial (Minimally Invasive Complete Response Assessment). Cancer Res. 2020;80(4 Supplement):GS5–06.

12.

Basik M, et al. Abstract GS5-05: Primary analysis of NRG-BR005, a phase II trial assessing accuracy of tumor bed biopsies in predicting pathologic complete response (pCR) in patients with clinical/radiological complete response after neoadjuvant chemotherapy (NCT) to explore the feasibility of breast-conserving treatment without surgery. Cancer Res. 2020;80(4 Supplement):GS5–05.

Titel: Therapies in flux: highlights of the 2019 San Antonio Breast Cancer Symposium (SABCS)
verfasst von: Simon Peter Gampenrieder
Publikationsdatum: 01.09.2020
Verlag: Springer Vienna
Erschienen in: memo - Magazine of European Medical Oncology / Ausgabe 3/2020
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI: https://doi.org/10.1007/s12254-020-00635-8

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Therapies in flux: highlights of the 2019 San Antonio Breast Cancer Symposium (SABCS)

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