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Erschienen in: Wiener klinische Wochenschrift 9-10/2016

01.05.2016 | original article

The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia

verfasst von: Ferdane Sapmaz, MD, Sebahat Başyiğit, MD, İsmail Hakkı Kalkan, MD, Üçler Kısa, MD, Engin Eren Kavak, MD, Sefa Güliter, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 9-10/2016

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Summary

Background and aim

The aim of this study was to evaluate the efficacy of bismuth-based quadruple regiment as a first-line treatment for Helicobacter pylori (H. pylori) eradication in patients with unexplained iron deficiency anemia (IDA). The serum hepcidin-25, iron, ferritin levels and total iron-binding capacity were evaluated at baseline and after H. pylori eradication in order to assess whether H. pylori eradication plays a role in IDA related to H. pylori infection.

Methods

The study included 80 patients with unexplained IDA and H. pylori infection. All patients received pantoprazole (40 mg b.i.d.), bismuth subcitrate (120 mg q.i.d.), tetracycline (500 mg q.i.d.) and metronidazole (500 mg t.i.d.) over 14 days as H. pylori eradication regimen. In all patients, blood samples were drawn at baseline and 1 month after eradication therapy. In all patients, serum hepcidin-25 levels were determined by using commercially available enzyme-linked immunosorbent assay kits.

Results

There was an improvement in hemoglobin, iron, total iron-binding capacity and ferritin values after H. pylori eradication in all subjects. Serum hepcidin-25 levels significantly decreased after H. pylori eradication (p < 0.001).

Conclusion

Gastric H. pylori infection is a common cause of IDA of unknown origin in adult patients. Our results provide evidence indicating that hepcidin level decreases after successful H. pylori eradication with improvement in IDA.
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Metadaten
Titel
The impact of Helicobacter pylori eradication on serum hepcidin-25 level and iron parameters in patients with iron deficiency anemia
verfasst von
Ferdane Sapmaz, MD
Sebahat Başyiğit, MD
İsmail Hakkı Kalkan, MD
Üçler Kısa, MD
Engin Eren Kavak, MD
Sefa Güliter, MD
Publikationsdatum
01.05.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 9-10/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-016-0961-5

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