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Erschienen in: Wiener klinische Wochenschrift 5-6/2015

01.03.2015 | original article

The association between thoracic periaortic fat and major adverse cardiovascular events

verfasst von: Assist. Prof. Zeynettin Kaya, MD, Assist. Prof. Seref Ulucan, Assoc. Prof. MehmetKayrak, Assist. Prof. Omer Akyurek, Assist. Prof. Huseyin Katlandur, Assist. Prof. Ahmet Keser, Assist. Prof. Duran Efe, Assist. Prof. Huseyin Ozdil, Prof. Mehmet S. Ulgen

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2015

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Abstract

Aim

The study aimed to examine the association between thoracic periaortic fat tissue volume and the long-term incidence of major adverse cardiovascular events.

Methods

This retrospective cohort study included 433 consecutive patients (372 male and 61 female). Periaortic fat tissue volume was measured via electrocardiogram-gated 64-multidetector computed tomography. The patients were evaluated on an average 3 years of follow-up for major adverse cardiovascular events. The patients were divided into groups according to the presence of major adverse cardiovascular events.

Results

Major adverse cardiovascular events were noted in 44 (10.2 %) patients during follow-up. Periaortic fat tissue volume was significantly higher in the major adverse cardiovascular events (+) group (35.4 ± 26.1 cm3 vs. 24.1 ± 14.9 cm3, P = 0.001). The logistic regression model showed that periaortic fat tissue volume (hazard ratio: 1.03; 95 % CI: 1.01–1.05; P = 0.001), the glomerular filtration rate (hazard ratio: 0.98; 95 % CI: 0.96–0.99; P = 0.03), and male gender (hazard ratio: 4.76; 95 % CI: 1.08–20.90; P = 0.04) were independent predictors of major adverse cardiovascular events.

Conclusion

Thoracic periaortic fat tissue volume may be considered a useful new parameter for predicting major adverse cardiovascular events.
Literatur
1.
Zurück zum Zitat Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis. J Atheroscler Thromb. 2010;17:115–30.CrossRefPubMed Spiroglou SG, Kostopoulos CG, Varakis JN, Papadaki HH. Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis. J Atheroscler Thromb. 2010;17:115–30.CrossRefPubMed
2.
Zurück zum Zitat Lee H-Y, Després J-P, Koh KK. Perivascular adipose tissue in the pathogenesis of cardiovascular disease. Atherosclerosis. 2013;230:177–84.CrossRefPubMed Lee H-Y, Després J-P, Koh KK. Perivascular adipose tissue in the pathogenesis of cardiovascular disease. Atherosclerosis. 2013;230:177–84.CrossRefPubMed
3.
Zurück zum Zitat Lehman SJ, Massaro JM, Schlett CL, O’Donnell CJ, Hoffmann U, Fox CS. Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study. Atherosclerosis. 2010;210:656–61.CrossRefPubMedCentralPubMed Lehman SJ, Massaro JM, Schlett CL, O’Donnell CJ, Hoffmann U, Fox CS. Peri-aortic fat, cardiovascular disease risk factors, and aortic calcification: the Framingham Heart Study. Atherosclerosis. 2010;210:656–61.CrossRefPubMedCentralPubMed
4.
Zurück zum Zitat Cheng K-H, Chu C-S, Lee K-T, Lin T-H, Hsieh C-C, Chiu C-C, et al. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes. 2008;32:268–74. Cheng K-H, Chu C-S, Lee K-T, Lin T-H, Hsieh C-C, Chiu C-C, et al. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes. 2008;32:268–74.
5.
Zurück zum Zitat Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol. 2007;27:996–1003.CrossRefPubMed Fantuzzi G, Mazzone T. Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol. 2007;27:996–1003.CrossRefPubMed
6.
Zurück zum Zitat Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand. 2005;184:285–93.CrossRefPubMed Trayhurn P. Endocrine and signalling role of adipose tissue: new perspectives on fat. Acta Physiol Scand. 2005;184:285–93.CrossRefPubMed
7.
Zurück zum Zitat Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 2009;22:1311–9; quiz 1417–8. Iacobellis G, Willens HJ. Echocardiographic epicardial fat: a review of research and clinical applications. J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 2009;22:1311–9; quiz 1417–8.
8.
Zurück zum Zitat Klopfenstein BJ, Kim MS, Krisky CM, Szumowski J, Rooney WD, Purnell JQ. Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans. Br J Radiol. 2012;85:e826–30.CrossRefPubMedCentralPubMed Klopfenstein BJ, Kim MS, Krisky CM, Szumowski J, Rooney WD, Purnell JQ. Comparison of 3 T MRI and CT for the measurement of visceral and subcutaneous adipose tissue in humans. Br J Radiol. 2012;85:e826–30.CrossRefPubMedCentralPubMed
9.
Zurück zum Zitat Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O’Donnell CJ, et al. Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study. Circ Cardiovasc Imaging. 2010;3:515–9.CrossRefPubMedCentralPubMed Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O’Donnell CJ, et al. Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study. Circ Cardiovasc Imaging. 2010;3:515–9.CrossRefPubMedCentralPubMed
10.
Zurück zum Zitat Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs JB, et al. Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study. J Am Heart Assoc. 2012;1:e000885.CrossRefPubMedCentralPubMed Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs JB, et al. Periaortic adipose tissue and aortic dimensions in the Framingham Heart Study. J Am Heart Assoc. 2012;1:e000885.CrossRefPubMedCentralPubMed
11.
Zurück zum Zitat Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41.CrossRefPubMed Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16:31–41.CrossRefPubMed
12.
Zurück zum Zitat Chityala R, Hoffmann KR, Bednarek DR, Rudin S. Region of Interest (ROI) Computed Tomography. Proc Soc Photo-Opt Instrum Eng. 2004;5368:534–41.PubMedCentralPubMed Chityala R, Hoffmann KR, Bednarek DR, Rudin S. Region of Interest (ROI) Computed Tomography. Proc Soc Photo-Opt Instrum Eng. 2004;5368:534–41.PubMedCentralPubMed
13.
Zurück zum Zitat Taylor J. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2506–7.CrossRefPubMed Taylor J. Third universal definition of myocardial infarction. Eur Heart J. 2012;33:2506–7.CrossRefPubMed
14.
Zurück zum Zitat Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol. 1993;22:6A–13A.CrossRefPubMed Ho KK, Pinsky JL, Kannel WB, Levy D. The epidemiology of heart failure: the Framingham Study. J Am Coll Cardiol. 1993;22:6A–13A.CrossRefPubMed
15.
Zurück zum Zitat Talaei M, Sadeghi M, Mohammadifard N, Shokouh P, Oveisgharan S, Sarrafzadegan N. Incident hypertension and its predictors: the Isfahan Cohort Study. J Hypertens. 2013;32(1):38–8. Talaei M, Sadeghi M, Mohammadifard N, Shokouh P, Oveisgharan S, Sarrafzadegan N. Incident hypertension and its predictors: the Isfahan Cohort Study. J Hypertens. 2013;32(1):38–8.
16.
Zurück zum Zitat Gu P, Jiang W, Lu B, Shi Z. Chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients. Clin Exp Hypertens NY 1993. 2013;36(5):326–32. Gu P, Jiang W, Lu B, Shi Z. Chemerin is associated with inflammatory markers and metabolic syndrome phenotypes in hypertension patients. Clin Exp Hypertens NY 1993. 2013;36(5):326–32.
17.
Zurück zum Zitat Diaz-Melean CM, Somers VK, Rodriguez-Escudero JP, Singh P, Sochor O, Llano EM, et al. Mechanisms of adverse cardiometabolic consequences of obesity. Curr Atheroscler Rep [Internet]. 2013[kaynak 27 Eylül 2013];15. Tarihinde adresinden eris¸ ildi: http://link.springer.com/10.1007/s11883-013-0364-2. Diaz-Melean CM, Somers VK, Rodriguez-Escudero JP, Singh P, Sochor O, Llano EM, et al. Mechanisms of adverse cardiometabolic consequences of obesity. Curr Atheroscler Rep [Internet]. 2013[kaynak 27 Eylül 2013];15. Tarihinde adresinden eris¸ ildi: http://​link.​springer.​com/​10.​1007/​s11883-013-0364-2.​
18.
Zurück zum Zitat Kammoun HL, Kraakman MJ, Febbraio MA. Adipose tissue inflammation in glucose metabolism. Rev Endocr Metab Disord. 2013;15(1):31–44.CrossRef Kammoun HL, Kraakman MJ, Febbraio MA. Adipose tissue inflammation in glucose metabolism. Rev Endocr Metab Disord. 2013;15(1):31–44.CrossRef
19.
Zurück zum Zitat Gröber-Grätz D, Widhalm K, de Zwaan M, Reinehr T, Blüher S, Schwab KO, et al. Body mass index or waist circumference: which is the better predictor for hypertension and dyslipidemia in overweight/obese children and adolescents? Association of cardiovascular risk related to body mass index or waist circumference. Horm Res Paediatr. 2013;80(3):170–8. Gröber-Grätz D, Widhalm K, de Zwaan M, Reinehr T, Blüher S, Schwab KO, et al. Body mass index or waist circumference: which is the better predictor for hypertension and dyslipidemia in overweight/obese children and adolescents? Association of cardiovascular risk related to body mass index or waist circumference. Horm Res Paediatr. 2013;80(3):170–8.
20.
Zurück zum Zitat Jolly US, Soliman A, McKenzie C, Peters T, Stirrat J, Nevis I, et al. Intra-thoracic fat volume is associated with myocardial infarction in patients with metabolic syndrome. J Cardiovasc Magn Reson 2013;15:77.CrossRefPubMedCentralPubMed Jolly US, Soliman A, McKenzie C, Peters T, Stirrat J, Nevis I, et al. Intra-thoracic fat volume is associated with myocardial infarction in patients with metabolic syndrome. J Cardiovasc Magn Reson 2013;15:77.CrossRefPubMedCentralPubMed
21.
Zurück zum Zitat Karastergiou K, Fried SK. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr Atheroscler Rep. [Internet]. 2013[kaynak 25 Eylül 2013];15. Tarihinde adresinden eris¸ ildi: zotero://attachment/91/ Karastergiou K, Fried SK. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr Atheroscler Rep. [Internet]. 2013[kaynak 25 Eylül 2013];15. Tarihinde adresinden eris¸ ildi: zotero://attachment/91/
22.
Zurück zum Zitat Gastaldelli A, Basta G. Ectopic fat and cardiovascular disease: what is the link? Nutr Metab Cardiovasc Dis NMCD. 2010;20:481–90.CrossRef Gastaldelli A, Basta G. Ectopic fat and cardiovascular disease: what is the link? Nutr Metab Cardiovasc Dis NMCD. 2010;20:481–90.CrossRef
23.
Zurück zum Zitat Britton KA, Wang N, Palmisano J, Corsini E, Schlett CL, Hoffmann U, et al. Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function: thoracic periaortic fat and vascular function. Obesity. 2013;21:1496–503.CrossRefPubMedCentralPubMed Britton KA, Wang N, Palmisano J, Corsini E, Schlett CL, Hoffmann U, et al. Thoracic periaortic and visceral adipose tissue and their cross-sectional associations with measures of vascular function: thoracic periaortic fat and vascular function. Obesity. 2013;21:1496–503.CrossRefPubMedCentralPubMed
24.
Zurück zum Zitat Baker AR, Silva NF da, Quinn DW, Harte AL, Pagano D, Bonser RS, et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol. 2006;5:1.CrossRefPubMedCentralPubMed Baker AR, Silva NF da, Quinn DW, Harte AL, Pagano D, Bonser RS, et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol. 2006;5:1.CrossRefPubMedCentralPubMed
25.
Zurück zum Zitat Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res. 2003;11:304–10.CrossRefPubMed Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res. 2003;11:304–10.CrossRefPubMed
26.
Zurück zum Zitat Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003;88:5163–8.CrossRefPubMed Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003;88:5163–8.CrossRefPubMed
27.
Zurück zum Zitat Iacobellis G, Leonetti F, Singh N, M Sharma A. Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int J Cardiol. 2007;115:272–3.CrossRefPubMed Iacobellis G, Leonetti F, Singh N, M Sharma A. Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int J Cardiol. 2007;115:272–3.CrossRefPubMed
28.
Zurück zum Zitat Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:781–6.CrossRefPubMed Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:781–6.CrossRefPubMed
29.
Zurück zum Zitat Iacobellis G, Willens HJ, Barbaro G, Sharma AM. Threshold values of high-risk echocardiographic epicardial fat thickness. Obes Silver Spring Md. 2008;16:887–92.CrossRef Iacobellis G, Willens HJ, Barbaro G, Sharma AM. Threshold values of high-risk echocardiographic epicardial fat thickness. Obes Silver Spring Md. 2008;16:887–92.CrossRef
30.
Zurück zum Zitat Flüchter S, Haghi D, Dinter D, Heberlein W, Kühl HP, Neff W, et al. Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging. Obes Silver Spring Md. 2007;15:870–8.CrossRef Flüchter S, Haghi D, Dinter D, Heberlein W, Kühl HP, Neff W, et al. Volumetric assessment of epicardial adipose tissue with cardiovascular magnetic resonance imaging. Obes Silver Spring Md. 2007;15:870–8.CrossRef
Metadaten
Titel
The association between thoracic periaortic fat and major adverse cardiovascular events
verfasst von
Assist. Prof. Zeynettin Kaya, MD
Assist. Prof. Seref Ulucan
Assoc. Prof. MehmetKayrak
Assist. Prof. Omer Akyurek
Assist. Prof. Huseyin Katlandur
Assist. Prof. Ahmet Keser
Assist. Prof. Duran Efe
Assist. Prof. Huseyin Ozdil
Prof. Mehmet S. Ulgen
Publikationsdatum
01.03.2015
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 5-6/2015
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0722-x

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