Skip to main content
Erschienen in: Spektrum der Augenheilkunde 6/2017

15.09.2017 | Angio-OCT/Medical Retina

Swept-source OCT and swept-source OCT angiography in glaucoma diagnostics

verfasst von: Stephan Kremmer, MD, PhD, Claudia Smok, Gerasimos Anastassiou

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 6/2017

Einloggen, um Zugang zu erhalten

Summary

Background

Swept-source OCT (SS-OCT) has been introduced as a fast method for examining the retinal nerve fiber layer (RNFL) and, like OCT angiography (OCTA), the structure of vessels in the retina and the optic nerve head. The aim of this study was to assess whether SS-OCT is able to detect different patterns of glaucomatous nerve fiber layer defects and to evaluate OCTA measurements in the same areas.

Material and methods

SS-OCT and OCTA data of glaucoma patients who were examined in the glaucoma unit of the Evangelisches Krankenhaus Gelsenkirchen between 2016 and 2017 were evaluated.

Results

In SS-OCT, a variety of signs indicating glaucomatous nerve fiber layer defects could be described, which corresponded to vessel defects, mainly of the small vessels and capillaries in OCTA. Samples are described in detail.

Conclusion

SS-OCT is able to detect different patterns of glaucomatous nerve fiber layer defects making it a helpful tool in glaucoma diagnostics. Most frequently, OCTA measurements show similar patterns of capillary rarefication indicating blood supply disturbances in these areas, too. Patients with more advanced OCTA damage may need additional internal and neurological work-up especially when the IOP is normal. Future studies with SS-OCT and OCTA at different stages of glaucoma and with long-term follow-up may provide new insight into the pathogenesis and course of the disease.
Literatur
1.
Zurück zum Zitat Vogt A. Herstellung eines gelbblauen Lichtfiltrates, in welchem die Macula centralis in vivo in gelber Färbung erscheint, die Nervenfasern der Netzhaut und andere feine Einzelheiten derselben sichtbar werden, und der Grad der Gelbfärbung der Linse ophthalmoskopisch nachweisbar ist. Graefes Arch Clin Exp Ophthalmol. 1913;84:293–311.CrossRef Vogt A. Herstellung eines gelbblauen Lichtfiltrates, in welchem die Macula centralis in vivo in gelber Färbung erscheint, die Nervenfasern der Netzhaut und andere feine Einzelheiten derselben sichtbar werden, und der Grad der Gelbfärbung der Linse ophthalmoskopisch nachweisbar ist. Graefes Arch Clin Exp Ophthalmol. 1913;84:293–311.CrossRef
2.
Zurück zum Zitat Hoyt WF, Friesen L, Newman NM. Funduscopy of nerve fiber layer defects in glaucoma. Invest Ophthalmol Vis Sci. 1973;12:814–29. Hoyt WF, Friesen L, Newman NM. Funduscopy of nerve fiber layer defects in glaucoma. Invest Ophthalmol Vis Sci. 1973;12:814–29.
3.
Zurück zum Zitat Airaksinen PJ, Nieminen H. Retinal nerve fiber layer photography in glaucoma. Ophthalmology. 1985;92:877–9.CrossRefPubMed Airaksinen PJ, Nieminen H. Retinal nerve fiber layer photography in glaucoma. Ophthalmology. 1985;92:877–9.CrossRefPubMed
4.
Zurück zum Zitat Tuulonen A, Airaksinen PJ. Initial glaucomatous optic disc and retinal nerve fiber layer abnormalities and their progression. Am J Ophthalmol. 1991;111:485–90.CrossRefPubMed Tuulonen A, Airaksinen PJ. Initial glaucomatous optic disc and retinal nerve fiber layer abnormalities and their progression. Am J Ophthalmol. 1991;111:485–90.CrossRefPubMed
5.
Zurück zum Zitat Hermann J, Funk J. Wertigkeit der Nervenfaserfotografie in der Glaukomdiagnostik. Ophthalmologe. 2005;102:778–82.CrossRef Hermann J, Funk J. Wertigkeit der Nervenfaserfotografie in der Glaukomdiagnostik. Ophthalmologe. 2005;102:778–82.CrossRef
6.
Zurück zum Zitat Kremmer S, Anastassiou G, Selbach JM. Stellenwert der Scanning Laser Polarimetrie für die Glaukomdiagnostik. [Clinical Value of Scanning Laser Polarimetry in Glaucoma Diagnostics]. Klin Monbl Augenheilkd. 2012;229:126–34.CrossRefPubMed Kremmer S, Anastassiou G, Selbach JM. Stellenwert der Scanning Laser Polarimetrie für die Glaukomdiagnostik. [Clinical Value of Scanning Laser Polarimetry in Glaucoma Diagnostics]. Klin Monbl Augenheilkd. 2012;229:126–34.CrossRefPubMed
7.
Zurück zum Zitat Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–93.CrossRefPubMed Flammer J, Orgül S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, et al. The impact of ocular blood flow in glaucoma. Prog Retin Eye Res. 2002;21:359–93.CrossRefPubMed
8.
Zurück zum Zitat Akil H, Falavarjani KG, Sadda SR, Sadun AA. Optical coherence tomography angiography of the optic disc; an overview. J Ophthalmic Vis Res. 2017;12:98–105.CrossRefPubMedPubMedCentral Akil H, Falavarjani KG, Sadda SR, Sadun AA. Optical coherence tomography angiography of the optic disc; an overview. J Ophthalmic Vis Res. 2017;12:98–105.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Klein T, Huber R. High-speed OCT light sources and systems. Biomed Opt Express. 2017;13:828–59.CrossRef Klein T, Huber R. High-speed OCT light sources and systems. Biomed Opt Express. 2017;13:828–59.CrossRef
11.
Zurück zum Zitat Jonas JB, Papastathopoulos KI. Optic disc shape in glaucoma. Graefes Arch Clin Exp Ophthalmol. 1996;234(Suppl 1):S167–73.CrossRefPubMed Jonas JB, Papastathopoulos KI. Optic disc shape in glaucoma. Graefes Arch Clin Exp Ophthalmol. 1996;234(Suppl 1):S167–73.CrossRefPubMed
12.
Zurück zum Zitat Aulhorn E. Pathophysiology of glaucomatous visual field defects. Fortschr Ophthalmol. 1988;85:601–6.PubMed Aulhorn E. Pathophysiology of glaucomatous visual field defects. Fortschr Ophthalmol. 1988;85:601–6.PubMed
13.
Zurück zum Zitat Hood DC, De Cuir N, Blumberg DM, Liebmann JM, Jarukasetphon R, Ritch R, et al. A single wide-field OCT protocol can provide compelling information for the diagnosis of early glaucoma. Transl Vis Sci Technol. 2016;5(6):4.CrossRefPubMedPubMedCentral Hood DC, De Cuir N, Blumberg DM, Liebmann JM, Jarukasetphon R, Ritch R, et al. A single wide-field OCT protocol can provide compelling information for the diagnosis of early glaucoma. Transl Vis Sci Technol. 2016;5(6):4.CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Zhang Q, Chen CL, Chu Z, Zheng F, Miller A, Roisman L, et al. Automated quantitation of choroidal neovascularization: a comparison study between spectral-domain and swept-source OCT angiograms. Invest Ophthalmol Vis Sci. 2017;58:1506–13.CrossRefPubMedPubMedCentral Zhang Q, Chen CL, Chu Z, Zheng F, Miller A, Roisman L, et al. Automated quantitation of choroidal neovascularization: a comparison study between spectral-domain and swept-source OCT angiograms. Invest Ophthalmol Vis Sci. 2017;58:1506–13.CrossRefPubMedPubMedCentral
18.
Zurück zum Zitat Michelson G, Langhans MJ, Harazny J, Dichtl A. Visual field defect and perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 1998;236:80–5.CrossRefPubMed Michelson G, Langhans MJ, Harazny J, Dichtl A. Visual field defect and perfusion of the juxtapapillary retina and the neuroretinal rim area in primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol. 1998;236:80–5.CrossRefPubMed
19.
Zurück zum Zitat Kur J, Newman EA, Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res. 2012;31:377–406.CrossRefPubMedPubMedCentral Kur J, Newman EA, Chan-Ling T. Cellular and physiological mechanisms underlying blood flow regulation in the retina and choroid in health and disease. Prog Retin Eye Res. 2012;31:377–406.CrossRefPubMedPubMedCentral
20.
Zurück zum Zitat Piltz-Deymour JR, Grunwald JE, Hariprasad SM, Dupont J. Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects. Am J Ophthalmol. 2001;132:63–9.CrossRef Piltz-Deymour JR, Grunwald JE, Hariprasad SM, Dupont J. Optic nerve blood flow is diminished in eyes of primary open-angle glaucoma suspects. Am J Ophthalmol. 2001;132:63–9.CrossRef
22.
Zurück zum Zitat Liu L, Jia Y, Takusagawa HL, Pechauer AD, Edmunds B, Lombardi L, et al. Optical coherence tomography angiography of the peripapillary retina in glaucoma. JAMA Ophthalmol. 2015;133:1045–52.CrossRefPubMedPubMedCentral Liu L, Jia Y, Takusagawa HL, Pechauer AD, Edmunds B, Lombardi L, et al. Optical coherence tomography angiography of the peripapillary retina in glaucoma. JAMA Ophthalmol. 2015;133:1045–52.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Zhi Z, Qin W, Wang J, Wei W, Wang RK. 4D optical coherence tomography based microangiography achieved by 1.6 MHz FDML swept source. Opt Lett. 2015;40(8):1779–82.CrossRefPubMedPubMedCentral Zhi Z, Qin W, Wang J, Wei W, Wang RK. 4D optical coherence tomography based microangiography achieved by 1.6 MHz FDML swept source. Opt Lett. 2015;40(8):1779–82.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Potsaid B, Baumann B, Huang D, Barry S, Cable AE, Schuman JS, et al. Ultra high speed 1050 nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Opt Express. 2010;18:20029–48.CrossRefPubMedPubMedCentral Potsaid B, Baumann B, Huang D, Barry S, Cable AE, Schuman JS, et al. Ultra high speed 1050 nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Opt Express. 2010;18:20029–48.CrossRefPubMedPubMedCentral
Metadaten
Titel
Swept-source OCT and swept-source OCT angiography in glaucoma diagnostics
verfasst von
Stephan Kremmer, MD, PhD
Claudia Smok
Gerasimos Anastassiou
Publikationsdatum
15.09.2017
Verlag
Springer Vienna
Erschienen in
Spektrum der Augenheilkunde / Ausgabe 6/2017
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI
https://doi.org/10.1007/s00717-017-0372-7

Weitere Artikel der Ausgabe 6/2017

Spektrum der Augenheilkunde 6/2017 Zur Ausgabe