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01.12.2012 | Original Article

Surgical treatment of synchronous and metachronous hepatic–and pulmonary colorectal cancer metastases —the Copenhagen experience

verfasst von: Peter Stemann Andersen, MD, Kåre Hornbech, MD, Peter Nørgaard Larsen, MD, Jesper Ravn, MD, Andre Wettergren, dr.med

Erschienen in: European Surgery | Ausgabe 6/2012

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Summary

Background

The surgical treatment of patients with isolated colorectal hepatic- or pulmonary metastases is well established with a 5-year survival in the range of 40–50 %. In contrast the treatment of patients with both hepatic- and pulmonary metastases remains controversial. We here present our initial results of patients who underwent both hepatic- and pulmonary resections for colorectal metastases with emphasis on post-operative complications and long-term survival.

Methods

The files of patients with metastasising colorectal cancer who underwent both hepatic- and pulmonary metastasectomy during 2003–2010 were reviewed retrospectively. Estimated overall survival and 1-, 3-, and 5-year survival rates were calculated by the method of Kaplan Meier. The log-rank test was used to compare patients survival for synchronous and metachronous metastases. A p value < 0.05 was considered significant.

Results

Nineteen patients were identified (9F/10M) with a median age of 63 years. Ten patients (53 %) presented with synchronous metastases and nine patients (47 %) with metachronous metastases. Only minor medical- and surgical complications were reported subsequent surgery. The 30-day mortality was zero. From time of resection of the primary colorectal tumour the estimated 5-year survival rate was 48.5 % with a median survival of 47 months. There were no difference in long-term survival between synchronous and metachronous metastases (p> 0.05).

Conclusions

The present study has demonstrated that resection of both hepatic and pulmonary colorectal metastases is safe and good long-term outcome can be obtained for selected patients. Thus, an aggressive surgical approach to patients with synchronous or metachronous hepatic and pulmonary metastases seems justified.
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Metadaten
Titel
Surgical treatment of synchronous and metachronous hepatic–and pulmonary colorectal cancer metastases —the Copenhagen experience
verfasst von
Peter Stemann Andersen, MD
Kåre Hornbech, MD
Peter Nørgaard Larsen, MD
Jesper Ravn, MD
Andre Wettergren, dr.med
Publikationsdatum
01.12.2012
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 6/2012
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-012-0174-8

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