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Erschienen in: Wiener klinische Wochenschrift 1-2/2024

26.04.2021 | original article

Subclinical atherosclerosis in patients with relapsing-remitting multiple sclerosis

verfasst von: Tomaž Omerzu, MD, Jožef Magdič, MD, Radovan Hojs, MD, PhD, Uroš Potočnik, PhD, Mario Gorenjak, MBI, PhD, Tanja Hojs Fabjan, MD, PhD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2024

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Summary

Background

Multiple sclerosis is an inflammatory disorder of the central nervous system. Inflammation may create high susceptibility to subclinical atherosclerosis. The purpose of this study was to compare subclinical atherosclerosis and the role of inflammatory cytokines between the group of patients with relapsing-remitting multiple sclerosis (RRMS) and healthy controls matched for age and sex.

Methods

The study group consisted of 112 non-diabetic and non-hypertensive RRMS patients treated with disease modifying drugs (DMD) and the control group was composed of 51 healthy subjects. The common carotid artery (CCA) intima media thickness (IMT) was investigated. Serum levels of risk factors for atherosclerosis and inflammatory cytokines were also determined.

Results

The mean CCA IMT (0.572 ± 0.131 mm vs. 0.571 ± 0.114 mm) did not differ (p > 0.05) between patients and controls. The RRMS patients’ CCA IMT was significantly correlated with serum interleukin 6 (IL-6) (p = 0.027), high-sensitivity C-reactive protein (hs-CRP) (p = 0.027), cystatin C (p < 0.0005), glucose (p = 0.031), cholesterol (p = 0.008), LDL (p = 0.021), erythrocyte sedimentation rate (p = 0.001) and triglyceride (p = 0.018) level. We fitted generalized linear models in order to assess the relationship between CCA IMT and IL‑6 with adjustment for sex and age. The obtained results showed that adjusted for age (p < 0.001) and sex (p = 0.048) IL‑6 serum levels statistically significantly (p = 0.009) predict CCA IMT only in the RRMS group.

Conclusion

The findings of the present study suggest that when treated with DMD RRMS might not be an independent risk factor for early atherosclerosis presenting with arterial wall thickening; however, the results suggest a significant association of IL‑6 serum levels with CCA IMT only in the RRMS group.
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Metadaten
Titel
Subclinical atherosclerosis in patients with relapsing-remitting multiple sclerosis
verfasst von
Tomaž Omerzu, MD
Jožef Magdič, MD
Radovan Hojs, MD, PhD
Uroš Potočnik, PhD
Mario Gorenjak, MBI, PhD
Tanja Hojs Fabjan, MD, PhD
Publikationsdatum
26.04.2021
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2024
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-021-01862-7

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