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Erschienen in: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen 1/2022

04.03.2022 | Originalien

Spondyloarthritiden im Kindes- und Erwachsenenalter

verfasst von: Dr. Toni Hospach, Gerd Horneff, Denis Poddubnyy

Erschienen in: Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen | Ausgabe 1/2022

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Zusammenfassung

Während sich die axiale Spondyloarthritis im Erwachsenenalter (SpAE) initial häufig mit einer Sakroiliitis manifestiert gilt dies nicht für die Enthesitis-assoziierte Arthritis (EAA) mit Beginn im Kindes-und Jugendalter. Klassischerweise beginnt die EAA mit peripherer Arthritis, und nur ein Teil geht in eine jSpA (juvenile Spondyloarthritis)/SpAE über. Die zur Klassifikation der SpAE und der EAA verwendeten Kriterien werden aktuell validiert bzw. neu überarbeitet. Dabei ist für die EAA erstmals auch die Bildgebung inkludiert. Therapeutisch werden bei beiden Erkrankungen initial NSAR (nichtsteroidale Antirheumatika) eingesetzt, gefolgt von Biologika bzw. synthetischen zielgerichteten krankheitsmodifizierenden Medikamenten bei refraktären Verläufen. Steroide sollten in der Langzeitbehandlung vermieden werden. Zur optimalen Transition und Weiterbetreuung im Erwachsenenalter ist eine enge Kooperation zwischen internistischen und pädiatrischen Rheumatologen notwendig.
Literatur
1.
Zurück zum Zitat Petty RE et al (2004) International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31(2):390–392PubMed Petty RE et al (2004) International league of associations for rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. J Rheumatol 31(2):390–392PubMed
2.
Zurück zum Zitat Goirand M et al (2018) Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Pediatr Rheumatol Online J 16(1):21PubMedPubMedCentral Goirand M et al (2018) Clinical features of children with enthesitis-related juvenile idiopathic arthritis / juvenile spondyloarthritis followed in a French tertiary care pediatric rheumatology centre. Pediatr Rheumatol Online J 16(1):21PubMedPubMedCentral
3.
Zurück zum Zitat Martini A et al (2019) Toward new classification criteria for juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus. J Rheumatol 46(2):190–197PubMed Martini A et al (2019) Toward new classification criteria for juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus. J Rheumatol 46(2):190–197PubMed
4.
Zurück zum Zitat Porter D, Basu N, Siebert S (2020) Classification criteria: time for a rethink? Ann Rheum Dis 79(10):1264–1266PubMed Porter D, Basu N, Siebert S (2020) Classification criteria: time for a rethink? Ann Rheum Dis 79(10):1264–1266PubMed
5.
Zurück zum Zitat Poddubnyy D (2020) Classification vs diagnostic criteria: the challenge of diagnosing axial spondyloarthritis. Rheumatology (Oxford) 59(4):iv6–iv17 Poddubnyy D (2020) Classification vs diagnostic criteria: the challenge of diagnosing axial spondyloarthritis. Rheumatology (Oxford) 59(4):iv6–iv17
6.
Zurück zum Zitat Minden K et al (2002) Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum 46(9):2392–2401PubMed Minden K et al (2002) Long-term outcome in patients with juvenile idiopathic arthritis. Arthritis Rheum 46(9):2392–2401PubMed
7.
Zurück zum Zitat Kiltz U et al (2012) Do patients with non-radiographic axial spondylarthritis differ from patients with ankylosing spondylitis? Arthritis Care Res (Hoboken) 64(9):1415–1422 Kiltz U et al (2012) Do patients with non-radiographic axial spondylarthritis differ from patients with ankylosing spondylitis? Arthritis Care Res (Hoboken) 64(9):1415–1422
8.
Zurück zum Zitat Rudwaleit M et al (2009) The early disease stage in axial spondylarthritis: results from the german spondyloarthritis inception cohort. Arthritis Rheum 60(3):717–727PubMed Rudwaleit M et al (2009) The early disease stage in axial spondylarthritis: results from the german spondyloarthritis inception cohort. Arthritis Rheum 60(3):717–727PubMed
9.
Zurück zum Zitat Dougados M et al (2001) Efficacy of celecoxib, a cyclooxygenase 2‑specific inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug. Arthritis Rheum 44(1):180–185PubMed Dougados M et al (2001) Efficacy of celecoxib, a cyclooxygenase 2‑specific inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug. Arthritis Rheum 44(1):180–185PubMed
10.
Zurück zum Zitat Gomez KS et al (1997) Juvenile onset ankylosing spondylitis—more girls than we thought? J Rheumatol 24(4):735–737PubMed Gomez KS et al (1997) Juvenile onset ankylosing spondylitis—more girls than we thought? J Rheumatol 24(4):735–737PubMed
11.
Zurück zum Zitat Sieper J, Poddubnyy D (2017) Axial spondyloarthritis. Lancet 390(10089):73–84PubMed Sieper J, Poddubnyy D (2017) Axial spondyloarthritis. Lancet 390(10089):73–84PubMed
12.
Zurück zum Zitat Brown MA et al (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40(10):1823–1828PubMed Brown MA et al (1997) Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40(10):1823–1828PubMed
13.
Zurück zum Zitat Sieper J, Poddubnyy D (2020) Pathogenesis of spondylarthritis : relevance for treatment. Z Rheumatol 79(1):5–12PubMed Sieper J, Poddubnyy D (2020) Pathogenesis of spondylarthritis : relevance for treatment. Z Rheumatol 79(1):5–12PubMed
14.
Zurück zum Zitat Gmuca S et al (2017) Multicenter inception cohort of enthesitis-related arthritis: variation in disease characteristics and treatment approaches. Arthritis Res Ther 19(1):84PubMedPubMedCentral Gmuca S et al (2017) Multicenter inception cohort of enthesitis-related arthritis: variation in disease characteristics and treatment approaches. Arthritis Res Ther 19(1):84PubMedPubMedCentral
15.
Zurück zum Zitat Weiss PF et al (2011) Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res 63(9):1307–1312 Weiss PF et al (2011) Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res 63(9):1307–1312
16.
Zurück zum Zitat Burgos-Vargas R (2012) The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: a critical appraisal for the pediatric rheumatologist. Pediatr Rheumatol Online J 10(1):14PubMedPubMedCentral Burgos-Vargas R (2012) The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: a critical appraisal for the pediatric rheumatologist. Pediatr Rheumatol Online J 10(1):14PubMedPubMedCentral
17.
Zurück zum Zitat Chen HA et al (2012) Clinical, functional, and radiographic differences among juvenile-onset, adult-onset, and late-onset ankylosing spondylitis. J Rheumatol 39(5):1013–1018PubMed Chen HA et al (2012) Clinical, functional, and radiographic differences among juvenile-onset, adult-onset, and late-onset ankylosing spondylitis. J Rheumatol 39(5):1013–1018PubMed
18.
Zurück zum Zitat Olivieri I et al (2012) Low frequency of axial involvement in southern Italian Caucasian children with HLA-B27 positive juvenile onset undifferentiated spondyloarthritis. Clin Exp Rheumatol 30(2):290–296PubMed Olivieri I et al (2012) Low frequency of axial involvement in southern Italian Caucasian children with HLA-B27 positive juvenile onset undifferentiated spondyloarthritis. Clin Exp Rheumatol 30(2):290–296PubMed
19.
Zurück zum Zitat Weiss PF et al (2011) Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res (Hoboken) 63(9):1307–1312 Weiss PF et al (2011) Enthesitis in an inception cohort of enthesitis-related arthritis. Arthritis Care Res (Hoboken) 63(9):1307–1312
20.
Zurück zum Zitat Burgos-Vargas R, Vazquez-Mellado J (1995) The early clinical recognition of juvenile-onset ankylosing spondylitis and its differentiation from juvenile rheumatoid arthritis. Arthritis Rheum 38(6):835–844PubMed Burgos-Vargas R, Vazquez-Mellado J (1995) The early clinical recognition of juvenile-onset ankylosing spondylitis and its differentiation from juvenile rheumatoid arthritis. Arthritis Rheum 38(6):835–844PubMed
21.
Zurück zum Zitat Weiss PF et al (2016) Assessment of sacroiliitis at diagnosis of juvenile spondyloarthritis by radiography, magnetic resonance imaging, and clinical examination. Arthritis Care Res 68(2):187–194 Weiss PF et al (2016) Assessment of sacroiliitis at diagnosis of juvenile spondyloarthritis by radiography, magnetic resonance imaging, and clinical examination. Arthritis Care Res 68(2):187–194
22.
Zurück zum Zitat Stoll ML et al (2010) Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. J Rheumatol 37(11):2402–2408PubMedPubMedCentral Stoll ML et al (2010) Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. J Rheumatol 37(11):2402–2408PubMedPubMedCentral
23.
Zurück zum Zitat Flatø B et al (2006) Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. Arthritis Rheum 54(11):3573–3582PubMed Flatø B et al (2006) Long-term outcome and prognostic factors in enthesitis-related arthritis: a case-control study. Arthritis Rheum 54(11):3573–3582PubMed
24.
Zurück zum Zitat Pagnini I et al (2010) Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. J Rheumatol 37(11):2395–2401PubMed Pagnini I et al (2010) Early predictors of juvenile sacroiliitis in enthesitis-related arthritis. J Rheumatol 37(11):2395–2401PubMed
25.
Zurück zum Zitat Terslev L et al (2014) Defining enthesitis in spondyloarthritis by ultrasound: results of a Delphi process and of a reliability reading exercise. Arthritis Care Res (Hoboken) 66(5):741–748 Terslev L et al (2014) Defining enthesitis in spondyloarthritis by ultrasound: results of a Delphi process and of a reliability reading exercise. Arthritis Care Res (Hoboken) 66(5):741–748
27.
Zurück zum Zitat Heiligenhaus A et al (2007) Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology (Oxford) 46(6):1015–1019 Heiligenhaus A et al (2007) Prevalence and complications of uveitis in juvenile idiopathic arthritis in a population-based nation-wide study in Germany: suggested modification of the current screening guidelines. Rheumatology (Oxford) 46(6):1015–1019
28.
29.
Zurück zum Zitat Walscheid K et al (2020) Enthesitis-related arthritis: prevalence and complications of associated uveitis in children and adolescents from a population-based nation-wide study in Germany. J Rheumatol 15(191085):191085 Walscheid K et al (2020) Enthesitis-related arthritis: prevalence and complications of associated uveitis in children and adolescents from a population-based nation-wide study in Germany. J Rheumatol 15(191085):191085
30.
Zurück zum Zitat Monnet D et al (2004) Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology 111(4):802–809PubMed Monnet D et al (2004) Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology 111(4):802–809PubMed
31.
Zurück zum Zitat Rademacher J, Poddubnyy D, Pleyer U (2020) Uveitis in spondyloarthritis. Ther Adv Musculoskelet Dis 12:1759720x20951733PubMedPubMedCentral Rademacher J, Poddubnyy D, Pleyer U (2020) Uveitis in spondyloarthritis. Ther Adv Musculoskelet Dis 12:1759720x20951733PubMedPubMedCentral
32.
Zurück zum Zitat Mielants H et al (1993) Gut inflammation in children with late onset pauciarticular juvenile chronic arthritis and evolution to adult spondyloarthropathy—a prospective study. J Rheumatol 20(9):1567–1572PubMed Mielants H et al (1993) Gut inflammation in children with late onset pauciarticular juvenile chronic arthritis and evolution to adult spondyloarthropathy—a prospective study. J Rheumatol 20(9):1567–1572PubMed
33.
Zurück zum Zitat Redeker I et al (2020) The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study. Ther Adv Musculoskelet Dis 12:1759720x20972610PubMedPubMedCentral Redeker I et al (2020) The impact of extra-musculoskeletal manifestations on disease activity, functional status, and treatment patterns in patients with axial spondyloarthritis: results from a nationwide population-based study. Ther Adv Musculoskelet Dis 12:1759720x20972610PubMedPubMedCentral
34.
Zurück zum Zitat Giani T et al (2020) Usefulness of magnetic resonance enterography in detecting signs of sacroiliitis in young patients with inflammatory bowel disease. Pediatr Rheumatol Online J 18(1):42PubMedPubMedCentral Giani T et al (2020) Usefulness of magnetic resonance enterography in detecting signs of sacroiliitis in young patients with inflammatory bowel disease. Pediatr Rheumatol Online J 18(1):42PubMedPubMedCentral
35.
Zurück zum Zitat Stoll ML, Punaro M, Patel AS (2011) Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. J Rheumatol 38(10):2274–2275PubMedPubMedCentral Stoll ML, Punaro M, Patel AS (2011) Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. J Rheumatol 38(10):2274–2275PubMedPubMedCentral
36.
Zurück zum Zitat Meier K et al (2020) Skin manifestations in spondyloarthritis. Ther Adv Musculoskelet Dis 12:1759720x20975915PubMedPubMedCentral Meier K et al (2020) Skin manifestations in spondyloarthritis. Ther Adv Musculoskelet Dis 12:1759720x20975915PubMedPubMedCentral
37.
Zurück zum Zitat Feld J et al (2020) Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis? Rheumatology (Oxford) 59(6):1340–1346 Feld J et al (2020) Is axial psoriatic arthritis distinct from ankylosing spondylitis with and without concomitant psoriasis? Rheumatology (Oxford) 59(6):1340–1346
38.
Zurück zum Zitat Rudwaleit M et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 68(10):1520–1527PubMed Rudwaleit M et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 68(10):1520–1527PubMed
39.
Zurück zum Zitat Maksymowych WP et al (2019) MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group. Ann Rheum Dis 78(11):1550–1558PubMed Maksymowych WP et al (2019) MRI lesions in the sacroiliac joints of patients with spondyloarthritis: an update of definitions and validation by the ASAS MRI working group. Ann Rheum Dis 78(11):1550–1558PubMed
40.
Zurück zum Zitat Baraliakos X et al (2020) Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged 〈45 years. Ann Rheum Dis 79(2):186–192PubMed Baraliakos X et al (2020) Frequency of MRI changes suggestive of axial spondyloarthritis in the axial skeleton in a large population-based cohort of individuals aged 〈45 years. Ann Rheum Dis 79(2):186–192PubMed
41.
Zurück zum Zitat Maksymowych WP et al (2020) Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria. Ann Rheum Dis 79(7):935–942PubMed Maksymowych WP et al (2020) Central reader evaluation of MRI scans of the sacroiliac joints from the ASAS classification cohort: discrepancies with local readers and impact on the performance of the ASAS criteria. Ann Rheum Dis 79(7):935–942PubMed
42.
Zurück zum Zitat Witte T et al (2020) IgA antibodies against CD74 are associated with structural damage in the axial skeleton in patients with axial spondyloarthritis. Clin Exp Rheumatol 38(6):1127–1131PubMed Witte T et al (2020) IgA antibodies against CD74 are associated with structural damage in the axial skeleton in patients with axial spondyloarthritis. Clin Exp Rheumatol 38(6):1127–1131PubMed
43.
Zurück zum Zitat Rieter JF et al (2016) The many shades of enhancement: timing of post-gadolinium images strongly influences the scoring of juvenile idiopathic arthritis wrist involvement on MRI. Pediatr Radiol 46(11):1562–1567PubMed Rieter JF et al (2016) The many shades of enhancement: timing of post-gadolinium images strongly influences the scoring of juvenile idiopathic arthritis wrist involvement on MRI. Pediatr Radiol 46(11):1562–1567PubMed
44.
Zurück zum Zitat Ording Muller LS et al (2013) MRI of the wrist in juvenile idiopathic arthritis: erosions or normal variants? A prospective case-control study. Pediatr Radiol 43(7):785–795PubMed Ording Muller LS et al (2013) MRI of the wrist in juvenile idiopathic arthritis: erosions or normal variants? A prospective case-control study. Pediatr Radiol 43(7):785–795PubMed
45.
Zurück zum Zitat Brophy S et al (2002) The natural history of ankylosing spondylitis as defined by radiological progression. J Rheumatol 29(6):1236–1243PubMed Brophy S et al (2002) The natural history of ankylosing spondylitis as defined by radiological progression. J Rheumatol 29(6):1236–1243PubMed
46.
Zurück zum Zitat Weber U et al (2015) Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis? Ann Rheum Dis 74(6):985–992PubMed Weber U et al (2015) Does spinal MRI add incremental diagnostic value to MRI of the sacroiliac joints alone in patients with non-radiographic axial spondyloarthritis? Ann Rheum Dis 74(6):985–992PubMed
47.
Zurück zum Zitat Vendhan K et al (2014) Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. Arthritis Care Res (Hoboken) 66(1):40–46 Vendhan K et al (2014) Inflammatory changes of the lumbar spine in children and adolescents with enthesitis-related arthritis: magnetic resonance imaging findings. Arthritis Care Res (Hoboken) 66(1):40–46
48.
Zurück zum Zitat Weiss PF, Roth J (2020) Juvenile-versus adult-onset spondyloarthritis: similar, but different. Rheum Dis Clin North Am 46(2):241–257PubMed Weiss PF, Roth J (2020) Juvenile-versus adult-onset spondyloarthritis: similar, but different. Rheum Dis Clin North Am 46(2):241–257PubMed
51.
Zurück zum Zitat Jousse-Joulin S et al (2011) Ultrasonography for detecting enthesitis in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) 63(6):849–855 Jousse-Joulin S et al (2011) Ultrasonography for detecting enthesitis in juvenile idiopathic arthritis. Arthritis Care Res (Hoboken) 63(6):849–855
52.
Zurück zum Zitat Kehl AS, Corr M, Weisman Review MH (2016) Enthesitis: new insights into pathogenesis, diagnostic modalities, and treatment. Arthritis Rheumatol 68(2):312–322PubMedPubMedCentral Kehl AS, Corr M, Weisman Review MH (2016) Enthesitis: new insights into pathogenesis, diagnostic modalities, and treatment. Arthritis Rheumatol 68(2):312–322PubMedPubMedCentral
53.
Zurück zum Zitat Herregods N et al (2015) Diagnostic value of MRI features of sacroiliitis in juvenile spondyloarthritis. Clin Radiol 70(12):1428–1438PubMed Herregods N et al (2015) Diagnostic value of MRI features of sacroiliitis in juvenile spondyloarthritis. Clin Radiol 70(12):1428–1438PubMed
55.
Zurück zum Zitat Poddubnyy D, Sieper J (2020) Treatment of axial spondyloarthritis: what does the future hold? Curr Rheumatol Rep 22(9):47PubMedPubMedCentral Poddubnyy D, Sieper J (2020) Treatment of axial spondyloarthritis: what does the future hold? Curr Rheumatol Rep 22(9):47PubMedPubMedCentral
56.
Zurück zum Zitat Althoff CE et al (2016) Comparison of clinical examination versus whole-body magnetic resonance imaging of enthesitis in patients with early axial spondyloarthritis during 3 years of continuous etanercept treatment. J Rheumatol 43(3):618–624PubMed Althoff CE et al (2016) Comparison of clinical examination versus whole-body magnetic resonance imaging of enthesitis in patients with early axial spondyloarthritis during 3 years of continuous etanercept treatment. J Rheumatol 43(3):618–624PubMed
57.
Zurück zum Zitat Machado P et al (2011) Ankylosing spondylitis disease activity score (ASDAS): defining cut-off values for disease activity states and improvement scores. Ann Rheum Dis 70(1):47–53PubMed Machado P et al (2011) Ankylosing spondylitis disease activity score (ASDAS): defining cut-off values for disease activity states and improvement scores. Ann Rheum Dis 70(1):47–53PubMed
58.
Zurück zum Zitat Heuft-Dorenbosch L et al (2003) Assessment of enthesitis in ankylosing spondylitis. Ann Rheum Dis 62(2):127–132PubMedPubMedCentral Heuft-Dorenbosch L et al (2003) Assessment of enthesitis in ankylosing spondylitis. Ann Rheum Dis 62(2):127–132PubMedPubMedCentral
59.
Zurück zum Zitat Maksymowych WP et al (2009) Development and validation of the spondyloarthritis research consortium of Canada (SPARCC) enthesitis index. Ann Rheum Dis 68(6):948–953PubMed Maksymowych WP et al (2009) Development and validation of the spondyloarthritis research consortium of Canada (SPARCC) enthesitis index. Ann Rheum Dis 68(6):948–953PubMed
60.
Zurück zum Zitat Redeker I et al (2020) Cost of illness in axial spondylarthritis for patients with and without tumor necrosis factor inhibitor treatment: results of a routine data analysis. Z Rheumatol 79(1):85–94 Redeker I et al (2020) Cost of illness in axial spondylarthritis for patients with and without tumor necrosis factor inhibitor treatment: results of a routine data analysis. Z Rheumatol 79(1):85–94
62.
Zurück zum Zitat Proft F et al (2020) Comparison of an online self-referral tool with a physician-based referral strategy for early recognition of patients with a high probability of axial spa. Semin Arthritis Rheum 50(5):1015–1021PubMed Proft F et al (2020) Comparison of an online self-referral tool with a physician-based referral strategy for early recognition of patients with a high probability of axial spa. Semin Arthritis Rheum 50(5):1015–1021PubMed
63.
Zurück zum Zitat Weiss PF et al (2020) Spondyloarthritis research consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children. Arthritis Res Ther 22(1):58PubMedPubMedCentral Weiss PF et al (2020) Spondyloarthritis research consortium of Canada sacroiliac joint inflammation and structural scores: change score reliability and recalibration utility in children. Arthritis Res Ther 22(1):58PubMedPubMedCentral
64.
Zurück zum Zitat Marino A et al (2020) Pharmacotherapy for juvenile spondyloarthritis: an overview of the available therapies. Expert Opin Pharmacother 29:1–8 Marino A et al (2020) Pharmacotherapy for juvenile spondyloarthritis: an overview of the available therapies. Expert Opin Pharmacother 29:1–8
66.
Zurück zum Zitat Hugle B et al (2014) Long-term outcome of anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondyloarthritis. Clin Exp Rheumatol 32(3):424–431PubMed Hugle B et al (2014) Long-term outcome of anti-tumor necrosis factor alpha blockade in the treatment of juvenile spondyloarthritis. Clin Exp Rheumatol 32(3):424–431PubMed
67.
Zurück zum Zitat Kiltz U, Braun J (2020) Current treatment of axial spondylarthritis : clinical efficacy. Z Rheumatol 79(1):13–22PubMed Kiltz U, Braun J (2020) Current treatment of axial spondylarthritis : clinical efficacy. Z Rheumatol 79(1):13–22PubMed
68.
Zurück zum Zitat Rohekar S et al (2015) 2014 update of the Canadian rheumatology association/spondyloarthritis research consortium of Canada treatment recommendations for the management of spondyloarthritis. Part II: specific management recommendations. J Rheumatol 42(4):665–681PubMed Rohekar S et al (2015) 2014 update of the Canadian rheumatology association/spondyloarthritis research consortium of Canada treatment recommendations for the management of spondyloarthritis. Part II: specific management recommendations. J Rheumatol 42(4):665–681PubMed
69.
Zurück zum Zitat Haibel H et al (2014) Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial. Ann Rheum Dis 73(1):243–246PubMed Haibel H et al (2014) Efficacy of oral prednisolone in active ankylosing spondylitis: results of a double-blind, randomised, placebo-controlled short-term trial. Ann Rheum Dis 73(1):243–246PubMed
70.
Zurück zum Zitat Chamlati R et al (2020) Image guided sacroiliac joint corticosteroid injections in children: an 18-year single-center retrospective study. Pediatr Rheumatol Online J 18(1):52PubMedPubMedCentral Chamlati R et al (2020) Image guided sacroiliac joint corticosteroid injections in children: an 18-year single-center retrospective study. Pediatr Rheumatol Online J 18(1):52PubMedPubMedCentral
71.
Zurück zum Zitat Fischer T et al (2003) Sacroiliitis in children with spondyloarthropathy: therapeutic effect of CT-guided intra-articular corticosteroid injection. Rofo 175(6):814–821PubMed Fischer T et al (2003) Sacroiliitis in children with spondyloarthropathy: therapeutic effect of CT-guided intra-articular corticosteroid injection. Rofo 175(6):814–821PubMed
72.
Zurück zum Zitat Huppertz HI et al (1995) Intraarticular corticosteroids for chronic arthritis in children: efficacy and effects on cartilage and growth. J Pediatr 127(2):317–321PubMed Huppertz HI et al (1995) Intraarticular corticosteroids for chronic arthritis in children: efficacy and effects on cartilage and growth. J Pediatr 127(2):317–321PubMed
73.
Zurück zum Zitat Breit W et al (2000) A subgroup-specific evaluation of the efficacy of intraarticular triamcinolone hexacetonide in juvenile chronic arthritis. J Rheumatol 27(11):2696–2702PubMed Breit W et al (2000) A subgroup-specific evaluation of the efficacy of intraarticular triamcinolone hexacetonide in juvenile chronic arthritis. J Rheumatol 27(11):2696–2702PubMed
74.
Zurück zum Zitat Burgos-Vargas R et al (2002) A 26 week randomised, double blind, placebo controlled exploratory study of sulfasalazine in juvenile onset spondyloarthropathies. Ann Rheum Dis 61(10):941–942PubMedPubMedCentral Burgos-Vargas R et al (2002) A 26 week randomised, double blind, placebo controlled exploratory study of sulfasalazine in juvenile onset spondyloarthropathies. Ann Rheum Dis 61(10):941–942PubMedPubMedCentral
75.
Zurück zum Zitat Ruperto N et al (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 50(7):2191–2201PubMed Ruperto N et al (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum 50(7):2191–2201PubMed
76.
Zurück zum Zitat Chen J et al (2013) Methotrexate for ankylosing spondylitis. Cochrane Database Syst Rev 2:CD4524 Chen J et al (2013) Methotrexate for ankylosing spondylitis. Cochrane Database Syst Rev 2:CD4524
77.
Zurück zum Zitat van der Heijde D et al (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76(6):978–991PubMed van der Heijde D et al (2017) 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis 76(6):978–991PubMed
78.
Zurück zum Zitat Poddubnyy D et al (2020) Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis. Rheumatology (Oxford) 59(12):3798–3806 Poddubnyy D et al (2020) Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis. Rheumatology (Oxford) 59(12):3798–3806
79.
Zurück zum Zitat Horneff G et al (2012) Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement. Arthritis Res Ther 14(5):R230PubMedPubMedCentral Horneff G et al (2012) Double-blind, placebo-controlled randomized trial with adalimumab for treatment of juvenile onset ankylosing spondylitis (JoAS): significant short term improvement. Arthritis Res Ther 14(5):R230PubMedPubMedCentral
80.
Zurück zum Zitat Weiss PF et al (2018) Comparative effectiveness of tumor necrosis factor agents and disease-modifying antirheumatic therapy in children with enthesitis-related arthritis: the first year after diagnosis. J Rheumatol 45(1):107–114PubMed Weiss PF et al (2018) Comparative effectiveness of tumor necrosis factor agents and disease-modifying antirheumatic therapy in children with enthesitis-related arthritis: the first year after diagnosis. J Rheumatol 45(1):107–114PubMed
81.
Zurück zum Zitat Ramanan AV et al (2017) Adalimumab plus methotrexate for uveitis in juvenile idiopathic arthritis. N Engl J Med 376(17):1637–1646PubMed Ramanan AV et al (2017) Adalimumab plus methotrexate for uveitis in juvenile idiopathic arthritis. N Engl J Med 376(17):1637–1646PubMed
82.
Zurück zum Zitat Hyams JS et al (2012) Safety and efficacy of adalimumab for moderate to severe Crohn’s disease in children. Gastroenterology 143(2):365–374.e2PubMed Hyams JS et al (2012) Safety and efficacy of adalimumab for moderate to severe Crohn’s disease in children. Gastroenterology 143(2):365–374.e2PubMed
83.
Zurück zum Zitat Bray TJP et al (2019) Sacroiliac joint ankylosis in young spondyloarthritis patients receiving biologic therapy: observation of serial magnetic resonance imaging scans. Arthritis Rheumatol 71(4):594–598PubMedPubMedCentral Bray TJP et al (2019) Sacroiliac joint ankylosis in young spondyloarthritis patients receiving biologic therapy: observation of serial magnetic resonance imaging scans. Arthritis Rheumatol 71(4):594–598PubMedPubMedCentral
84.
Zurück zum Zitat Koo BS et al (2020) Tumour necrosis factor inhibitors slow radiographic progression in patients with ankylosing spondylitis: 18-year real-world evidence. Ann Rheum Dis 79(10):1327–1332PubMed Koo BS et al (2020) Tumour necrosis factor inhibitors slow radiographic progression in patients with ankylosing spondylitis: 18-year real-world evidence. Ann Rheum Dis 79(10):1327–1332PubMed
85.
Zurück zum Zitat Baeten D et al (2015) Secukinumab, an Interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med 373(26):2534–2548PubMed Baeten D et al (2015) Secukinumab, an Interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med 373(26):2534–2548PubMed
87.
Zurück zum Zitat van der Heijde D et al (2018) Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial. Lancet 392(10163):2441–2451PubMed van der Heijde D et al (2018) Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with biological disease-modifying anti-rheumatic drugs (COAST-V): 16 week results of a phase 3 randomised, double-blind, active-controlled and placebo-controlled trial. Lancet 392(10163):2441–2451PubMed
88.
Zurück zum Zitat Deodhar A et al (2020) Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial. Lancet 395(10217):53–64PubMed Deodhar A et al (2020) Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial. Lancet 395(10217):53–64PubMed
89.
Zurück zum Zitat Dougados M et al (2020) Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST‑V and COAST-W). Ann Rheum Dis 79(2):176–185PubMed Dougados M et al (2020) Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST‑V and COAST-W). Ann Rheum Dis 79(2):176–185PubMed
90.
Zurück zum Zitat Erdes S et al (2020) Primary efficacy of netakimab, a novel interleukin-17 inhibitor, in the treatment of active ankylosing spondylitis in adults. Clin Exp Rheumatol 38(1):27–34PubMed Erdes S et al (2020) Primary efficacy of netakimab, a novel interleukin-17 inhibitor, in the treatment of active ankylosing spondylitis in adults. Clin Exp Rheumatol 38(1):27–34PubMed
91.
Zurück zum Zitat van der Heijde D et al (2020) Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study. Ann Rheum Dis 79(5):595–604PubMed van der Heijde D et al (2020) Dual neutralisation of interleukin-17A and interleukin-17F with bimekizumab in patients with active ankylosing spondylitis: results from a 48-week phase IIb, randomised, double-blind, placebo-controlled, dose-ranging study. Ann Rheum Dis 79(5):595–604PubMed
92.
Zurück zum Zitat Akkoc N, Khan MA (2021) JAK inhibitors for axial spondyloarthritis: what does the future hold? Curr Rheumatol Rep 23(6):34PubMed Akkoc N, Khan MA (2021) JAK inhibitors for axial spondyloarthritis: what does the future hold? Curr Rheumatol Rep 23(6):34PubMed
93.
Zurück zum Zitat van der Heijde D et al (2017) Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study. Ann Rheum Dis 76(8):1340–1347PubMed van der Heijde D et al (2017) Tofacitinib in patients with ankylosing spondylitis: a phase II, 16-week, randomised, placebo-controlled, dose-ranging study. Ann Rheum Dis 76(8):1340–1347PubMed
94.
Zurück zum Zitat van der Heijde D et al (2018) Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial. Lancet 392(10162):2378–2387PubMed van der Heijde D et al (2018) Efficacy and safety of filgotinib, a selective Janus kinase 1 inhibitor, in patients with active ankylosing spondylitis (TORTUGA): results from a randomised, placebo-controlled, phase 2 trial. Lancet 392(10162):2378–2387PubMed
95.
Zurück zum Zitat van der Heijde D et al (2019) Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial. Lancet 394(10214):2108–2117PubMed van der Heijde D et al (2019) Efficacy and safety of upadacitinib in patients with active ankylosing spondylitis (SELECT-AXIS 1): a multicentre, randomised, double-blind, placebo-controlled, phase 2/3 trial. Lancet 394(10214):2108–2117PubMed
97.
Zurück zum Zitat Flatø B et al (2002) The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum 46(4):986–994PubMed Flatø B et al (2002) The influence of patient characteristics, disease variables, and HLA alleles on the development of radiographically evident sacroiliitis in juvenile idiopathic arthritis. Arthritis Rheum 46(4):986–994PubMed
98.
Zurück zum Zitat Berntson L et al (2008) HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis. J Rheumatol 35(10):2055–2061PubMed Berntson L et al (2008) HLA-B27 predicts a more extended disease with increasing age at onset in boys with juvenile idiopathic arthritis. J Rheumatol 35(10):2055–2061PubMed
99.
Zurück zum Zitat Feldtkeller E et al (2003) Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 23(2):61–66PubMed Feldtkeller E et al (2003) Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis. Rheumatol Int 23(2):61–66PubMed
100.
Zurück zum Zitat Gensler LS et al (2008) Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis 67(2):233–237PubMed Gensler LS et al (2008) Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis 67(2):233–237PubMed
101.
Zurück zum Zitat Baek HJ et al (2002) Juvenile onset ankylosing spondylitis (JAS) has less severe spinal disease course than adult onset ankylosing spondylitis (AAS): clinical comparison between JAS and AAS in Korea. J Rheumatol 29(8):1780–1785PubMed Baek HJ et al (2002) Juvenile onset ankylosing spondylitis (JAS) has less severe spinal disease course than adult onset ankylosing spondylitis (AAS): clinical comparison between JAS and AAS in Korea. J Rheumatol 29(8):1780–1785PubMed
102.
Zurück zum Zitat Kim TJ et al (2016) Comparison on radiographic progression for 5 years between juvenile onset ankylosing spondylitis and adult onset ankylosing spondylitis: an observational study of the Korean SpondyloArthropathy registry (OSKAR) data. Clin Exp Rheumatol 34(4):668–672PubMed Kim TJ et al (2016) Comparison on radiographic progression for 5 years between juvenile onset ankylosing spondylitis and adult onset ankylosing spondylitis: an observational study of the Korean SpondyloArthropathy registry (OSKAR) data. Clin Exp Rheumatol 34(4):668–672PubMed
103.
Zurück zum Zitat Beukelman T et al (2011) 2011 American college of rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res (Hoboken) 63(4):465–482 Beukelman T et al (2011) 2011 American college of rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features. Arthritis Care Res (Hoboken) 63(4):465–482
104.
Zurück zum Zitat Mease PJ et al (2020) Characterization of patients with axial spondyloarthritis by enthesitis presence: data from the corrona psoriatic arthritis/spondyloarthritis registry. ACR Open Rheumatol 2(7):449–456PubMedPubMedCentral Mease PJ et al (2020) Characterization of patients with axial spondyloarthritis by enthesitis presence: data from the corrona psoriatic arthritis/spondyloarthritis registry. ACR Open Rheumatol 2(7):449–456PubMedPubMedCentral
105.
Zurück zum Zitat Braun J, Pincus T (2002) Mortality, course of disease and prognosis of patients with ankylosing spondylitis. Clin Exp Rheumatol 20(6):S16–22PubMed Braun J, Pincus T (2002) Mortality, course of disease and prognosis of patients with ankylosing spondylitis. Clin Exp Rheumatol 20(6):S16–22PubMed
106.
Zurück zum Zitat Prati C et al (2011) Mortality in spondylarthritis. Joint Bone Spine 78(5):466–470PubMed Prati C et al (2011) Mortality in spondylarthritis. Joint Bone Spine 78(5):466–470PubMed
107.
Zurück zum Zitat Bakland G, Gran JT, Nossent JC (2011) Increased mortality in ankylosing spondylitis is related to disease activity. Ann Rheum Dis 70(11):1921–1925PubMed Bakland G, Gran JT, Nossent JC (2011) Increased mortality in ankylosing spondylitis is related to disease activity. Ann Rheum Dis 70(11):1921–1925PubMed
Metadaten
Titel
Spondyloarthritiden im Kindes- und Erwachsenenalter
verfasst von
Dr. Toni Hospach
Gerd Horneff
Denis Poddubnyy
Publikationsdatum
04.03.2022
Verlag
Springer Vienna
Erschienen in
Journal für Mineralstoffwechsel & Muskuloskelettale Erkrankungen / Ausgabe 1/2022
Print ISSN: 2412-8260
Elektronische ISSN: 2412-8287
DOI
https://doi.org/10.1007/s41970-022-00184-y

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