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12.12.2019 | original article | Ausgabe 1-2/2020 Open Access

Wiener klinische Wochenschrift 1-2/2020

Spermidine in dementia

Relation to age and memory performance

Zeitschrift:
Wiener klinische Wochenschrift > Ausgabe 1-2/2020
Autoren:
MA Dr. Thomas Pekar, MSc Aribert Wendzel, Dr. Walter Flak, Mag. Alexandra Kremer, Susanne Pauschenwein-Frantsich, BSc Anna Gschaider, Univ. Doz. Dr. Felix Wantke, Univ. Prof. Dr. Reinhart Jarisch
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Summary

Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60–96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer’s disease).

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