Skip to main content


Weitere Artikel dieser Ausgabe durch Wischen aufrufen

12.12.2019 | original article | Ausgabe 1-2/2020 Open Access

Wiener klinische Wochenschrift 1-2/2020

Spermidine in dementia

Relation to age and memory performance

Wiener klinische Wochenschrift > Ausgabe 1-2/2020
MA Dr. Thomas Pekar, MSc Aribert Wendzel, Dr. Walter Flak, Mag. Alexandra Kremer, Susanne Pauschenwein-Frantsich, BSc Anna Gschaider, Univ. Doz. Dr. Felix Wantke, Univ. Prof. Dr. Reinhart Jarisch
Wichtige Hinweise

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.


Previous studies have highlighted that spermidine has the ability to trigger the important process of dissolving amyloid-beta plaques by autophagy. This manuscript focuses on the correlation of serum spermidine levels between age and between performance in mini-mental state examinations. It will serve as a premise for an ongoing multicentric placebo-controlled study, which focuses on the effect of oral spermidine supplementation on memory performance. Memory tests were carried out on 80 subjects aged 60–96 years old in 6 nursing homes in Styria. Blood samples were taken for the determination of spermidine concentration. The results showed a significant correlation between the spermidine concentration and the mini-mental state examination score (p = 0.025). On the basis of the dependence demonstrated it can be concluded that spermidine might be suitable as a biomarker for the diagnosis of neurocognitive changes (senile dementia or Alzheimer’s disease).

Unsere Produktempfehlungen

Abo für kostenpflichtige Inhalte

Über diesen Artikel

Weitere Artikel der Ausgabe 1-2/2020

Wiener klinische Wochenschrift 1-2/2020 Zur Ausgabe

mitteilungen der gesellschaft der ärzte in wien


mitteilungen der gesellschaft

mitteilungen der gesellschaft