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Erschienen in: Spektrum der Augenheilkunde 1/2017

Open Access 01.02.2017 | case report

Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis

Case report of a patient with Sjögren’s syndrome

verfasst von: MD Christoph Palme, MD Bernhard Steger, MD Gertrud Haas, MD Barbara Teuchner, MD Nikolaos E. Bechrakis

Erschienen in: Spektrum der Augenheilkunde | Ausgabe 1/2017

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Summary

Purpose

We report on a case of Acanthamoeba keratitis (AK)-related reactive ischemic posterior segment inflammation following intraocular surgery in a patient with primary Sjögren’s syndrome (PSS).

Case report

A 48-year-old female patient with severe protracted AK underwent uneventful cataract surgery upon development of a corneal scar. Four weeks postoperatively, she experienced a rapid loss of vision to no light perception. Central retinal artery occlusion and ischemic optic neuropathy could be excluded, and a diagnosis of PSS was made. The condition remained unresponsive to systemic steroid treatment and ultimately led to enucleation of the globe. Histologic work-up revealed ischemic posterior segment inflammation and Acanthamoeba cysts in the corneal stroma.

Conclusion

Autoimmune disease may be a risk factor for AK-related severe reactive ischemic posterior segment inflammation, and intraocular surgery can be a trigger to its manifestation.

Introduction

Reactive ischemic posterior segment inflammation (RIPSI) has been reported as a rare sight-threatening manifestation of prolonged severe Acanthamoeba keratitis (AK) [1]. Occurring especially in patients with underlying hypercoagulation disorders, histopathologic correlates include chronic chorioretinal inflammation with perivascular lymphocytic infiltration and retinal vascular thrombosis. Primary Sjögren’s syndrome (PSS) is a chronic inflammatory autoimmune disorder that causes destruction of lacrimal and salivary glands [2]. Ischemic optic neuropathy and choroidopathy have been reported as sight-threatening manifestations of PSS [3, 4]. We report on a case of AK-related reactive ischemic posterior segment inflammation in a patient with this autoimmune disease.

Case report

A 48-year-old female myopic patient presented with a 3-week history of progressive pain in her left eye. She had been wearing rigid gas permeable contact lenses and used self-prescribed antibiotic and steroid eye drops. Her past medical and ocular history was unremarkable. Initial best corrected visual acuity (BCVA) was counting fingers. Biomicroscopic examination revealed a large ring-shaped corneal stromal infiltrate, a central corneal epithelial defect in the absence of a hypopyon (Fig. 1a). In vivo confocal microscopy (IVCM) of the cornea was performed and confirmed the clinically suspected diagnosis of AK, showing a large number of Acanthamoeba cysts in the anterior stroma (Fig. 1b). Full ophthalmologic examination of the other eye was unremarkable apart from signs of moderate dry eye disease. The patient was hospitalized and treated with a topical antimicrobial treatment regimen consisting of half-hourly polyhexamethylene biguanide 0.02%, chlorhexidine 0.02%, and propamidine isethionate (0.1%). Additionally, topical treatment with tobramycin and fluconazole eye drops was initiated upon culture results from the contact lens positive for Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans. Under this treatment the infiltrate improved significantly and the patient could be discharged with a BCVA of 0.80 on a LogMAR scale with ongoing topical treatment.
After 3 months and settled inflammation, the patient’s BCVA deteriorated to hand movements secondary to a white intumescent cataract with lens swelling. She underwent uncomplicated phacoemulsification surgery with implantation of a posterior chamber intraocular lens. Postoperative BCVA improved to 0.60 LogMAR. Four weeks postoperatively the patient experienced a rapid painless loss of vision to no perception of light. Clinical examination was remarkable for profound ocular hypotension with an intraocular pressure of 4 mm Hg. Optical coherence tomography (OCT) of the macula, although of reduced quality, showed hypotensive maculopathy with macular folds due to choroidal effusion, and mild optic disc edema. Fluorescence angiographic imaging of the retinal vasculature was attempted but remained inconclusive because of reduced fundus visibility. Optic neuritis and demyelinating disease of the central nervous system were ruled out by magnetic resonance imaging. No focal neurologic signs were present. Visual evoked potentials were attenuated and delayed in the affected eye. Further diagnostic work-up yielded positive results for anti-SSA (Ro) autoantibodies and increased levels of antinuclear antibodies, whereas anti-phospholipid antibodies and lupus anti-coagulant remained negative. Additionally, ultrasonographic examination of the parotid gland revealed evident parenchymal inhomogeneity verifying salivary gland involvement [5]. The patient confirmed symptoms of dry eyes, dry mouth, and relapsing arthritis and was diagnosed with PSS by the local rheumatology service meeting current diagnostic consensus criteria [6]. She was treated with prednisolone 250 mg and acetylsalicylic acid 100 mg once daily but did not regain any vision. Subsequently, she developed neuropathic corneal ulceration, band keratopathy in the setting of ocular hypotension, which ultimately necessitated enucleation of the eye. Histologic work-up revealed numerous Acanthamoeba cysts in the corneal stroma but no intraocular cysts. Intraocular findings included lymphocytic infiltrates in the choroidal stroma, around the choroidal veins and the short posterior ciliary arteries, diffuse retinal atrophy, but no evidence of retinal vascular thrombosis (Fig. 1c, d). No multinucleated perivascular cells were identified.

Discussion

In the presented case, a patient with previously undiagnosed PSS developed AK-related severe reactive ischemic posterior segment inflammation (RIPSI) with a dismal outcome following intraocular surgery. AK-induced autoimmunity has previously been discussed as the underlying disease mechanism of retinal and choroidal vasculitis. RIPSI has been described as severe visual loss in patients with protracted and refractory AK. Histopathologic correlates include chorioretinal inflammation with perivascular lymphocytic infiltration and retinal vascular thrombosis, as present in our patient [1].
Hamrah et al. showed that in keratitis corneal antigen-presenting cells can migrate to the cervical lymph nodes and induce a state of autoimmunity through molecular mimicry. Activated T cells can in turn initiate a significant inflammatory reaction in the vascularized parts of the globe, mainly the uveal tissue and the retina [7]. Autoimmune ischemic choroidopathy likewise is a known complication of PSS, potentially precipitated by infection-related inflammatory response with induction of the interferon-1 (IFN-1) pathway [4, 8]. However, histopathologic examination of isolated PSS-related optic neuropathy would not be expected to show pronounced perivascular inflammatory cell infiltration in large choroidal vessels, as shown in Fig. 1, since it fits more accurately the previously described findings in RIPSI.
Furthermore, even uncomplicated intraocular surgery significantly increases intraocular and systemic levels of pro-inflammatory cytokines including IFN-1 [9]. Awwad et al. described an association with hypercoagulation disorders, but no patient was found to suffer from autoimmune disease. However, the authors discuss the possible induction of a state of autoimmunity through molecular mimicry via corneal antigen-presenting cells. A type III immune reaction could form and may target distal vascular tissue receptors leading to vasculitis and vascular thrombosis, ending with tissue necrosis [1]. In addition, our findings point toward an association between autoimmune disease and AK-related RIPSI, and intraocular surgery as a trigger to its manifestation.
Open access funding provided by University of Innsbruck and Medical University of Innsbruck.

Conflict of interest

C. Palme, B. Steger, G. Haas, B. Teuchner, and N.E. Bechrakis declare that they have no competing interests.
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Metadaten
Titel
Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis
Case report of a patient with Sjögren’s syndrome
verfasst von
MD Christoph Palme
MD Bernhard Steger
MD Gertrud Haas
MD Barbara Teuchner
MD Nikolaos E. Bechrakis
Publikationsdatum
01.02.2017
Verlag
Springer Vienna
Erschienen in
Spektrum der Augenheilkunde / Ausgabe 1/2017
Print ISSN: 0930-4282
Elektronische ISSN: 1613-7523
DOI
https://doi.org/10.1007/s00717-017-0334-0