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Erschienen in: Wiener klinische Wochenschrift 1-2/2016

01.01.2016 | original article

Serum soluble urokinase-type plasminogen activator receptor and interferon-γ-induced protein 10 levels correlate with significant fibrosis in chronic hepatitis B

verfasst von: MD Dilek Yıldız Sevgi, Assoc. Prof. Banu Bayraktar, MD Alper Gündüz, MD Banu Yılmaz Özgüven, MD Alper Togay, MD Emin Bulut, MD Nuray Uzun, Prof. İlyas Dökmetaş

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 1-2/2016

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Summary

Background

Hepatitis B virus (HBV) presents an important public health problem. Liver biopsy is currently the gold standard for assessing the degree of intrahepatic inflammation and for staging liver fibrosis. However, the value of liver biopsies is limited by sampling errors, understaging and interobserver variability in interpretation. There is, therefore, a need to identify novel, non-invasive serologic biomarkers for the development of new predictive models of fibrosis.

Methods

We enrolled patients with chronic hepatitis B infection (CHB) and examined the relationships between serum soluble urokinase plasminogen activator receptor (suPAR) and interferon-induced protein-10 (IP-10), and the results of liver biopsies. Healthy volunteers with normal aminotransferase levels and negative serological results for HBV, hepatitis C virus and human immunodeficiency virus were recruited as controls.

Results

Mean platelet volume, serum suPAR and IP-10 were significantly elevated in patients with CHB compared with controls. Median serum suPAR and IP-10 levels were significantly higher in patients with liver fibrosis compared with patients with mild fibrosis. There was no significant difference in mean platelet volume or aspartate aminotransferase-to-platelet ratio index scores between patients with mild and significant fibrosis.

Conclusion

suPAR and IP-10 were able to distinguish between significant and mild fibrosis with good sensitivity and specificity, and may thus represent useful biomarkers for identifying patients with significant fibrosis.
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Metadaten
Titel
Serum soluble urokinase-type plasminogen activator receptor and interferon-γ-induced protein 10 levels correlate with significant fibrosis in chronic hepatitis B
verfasst von
MD Dilek Yıldız Sevgi
Assoc. Prof. Banu Bayraktar
MD Alper Gündüz
MD Banu Yılmaz Özgüven
MD Alper Togay
MD Emin Bulut
MD Nuray Uzun
Prof. İlyas Dökmetaş
Publikationsdatum
01.01.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 1-2/2016
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-015-0886-4