Skip to main content
main-content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

01.04.2017 | main topic | Ausgabe 5-6/2017

Wiener Medizinische Wochenschrift 5-6/2017

Sclerosing epithelioid fibrosarcoma

Zeitschrift:
Wiener Medizinische Wochenschrift > Ausgabe 5-6/2017
Autoren:
MD Prof. Dr. James W. Patterson, PhD Prof. Dr. Georgi Tchernev, Dr. Anastasiya Atanasova Chokoeva, MD Mark R. Wick

Summary

We report the case of a 55-year-old woman who developed a mass in the soft tissue of the anterior right proximal thigh. Microscopic findings in the biopsy specimen supported the diagnosis of sclerosing epithelioid fibrosarcoma (SEF). This entity is part of a spectrum of lesions that includes low-grade fibromyxoid sarcoma (LGFMS) and hyalinizing spindle cell tumor with giant rosettes (HSCTGR). It shares with LGFMS occasional overlapping histopathologic features and immunopositivity for MUC4. Although FUS and CREB3L2 gene rearrangements, characteristics of LGFMS, have been found in hybrid tumors (those with features of both SEF and LGFMS) and in examples of LGFMS with relapses showing SEF morphology, it appears that EWSR1 and CREB3L1 rearrangements predominate over FUS and CREB3L2 rearrangements among “pure” SEF tumors. Recent information about SEF is briefly reviewed.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5-6/2017

Wiener Medizinische Wochenschrift 5-6/2017Zur Ausgabe