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17.01.2018 | review | Ausgabe 3/2018

memo - Magazine of European Medical Oncology 3/2018

Role of complement in the pathogenesis of thrombotic microangiopathies

Zeitschrift:
memo - Magazine of European Medical Oncology > Ausgabe 3/2018
Autoren:
Eszter Trojnár, Ágnes Szilágyi, Bálint Mikes, Dorottya Csuka, György Sinkovits, Prof. Zoltán Prohászka

Summary

Thrombotic microangiopathies (TMAs) are rare but life-threatening disorders characterized by microvascular hemolytic anemia and acute thrombocytopenia with or without organ damage. The term TMA covers various subgroups of diseases, the pathogenesis of which is briefly summarized in this review. As highlighted here, complement activation may represent an important amalgamating process in all of these conditions, since it is able to link together activation and damage of multiple involved cell types, such as endothelial cells, platelets, and neutrophils.

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