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Erschienen in: European Surgery 4/2016

01.08.2016 | Original Article

Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma

verfasst von: P. Téoule, M. Distler, M. Niedergethmann, T. Gaiser, F. Rückert, R. Grützmann, T. J. Wilhelm

Erschienen in: European Surgery | Ausgabe 4/2016

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Summary

Background

Sporadic duodenal cancer is a rare cancer entity. Therefore, the prognostic significance of clinicopathologic features is unknown. This study aimed to identify prognostic factors and compare survival with other tumour entities of the same anatomical region.

Methods

We retrospectively studied medical records of 22 patients with duodenal adenocarcinoma (DAC), who underwent resection in two German centres for pancreatic surgery (1994–2012). Mean time of follow-up was 51.3 months. Predictive factors were evaluated by log rank analysis.

Results

Whipple surgery was performed in seven cases (31.8 %), pylorus preserving pancreaticoduodenectomy in 14 cases (63.6 %) and partial duodenectomy in one case (4.5 %). R0-resection was achieved in 86.4 %. In all, 50% of our patients had nodal positive disease. Overall morbidity was 59.1 % and perioperative mortality was 9.1 %. Survival after resection was 63.6 % and 59.0 % (3- and 5-years). There was no significant survival difference between patients with DAC and ampullary cancer, but survival was longer compared with patients with pancreatic cancer.

Conclusions

Mortality seems to be high after resection of DAC. However, radical surgery should be performed due to the high number of patients with nodal positive disease. No definite prognostic factors were identified. The prognosis after resection of duodenal cancer can be compared with patients with ampullary cancer.
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Metadaten
Titel
Retrospective analysis of prognostic factors in patients with duodenal adenocarcinoma
verfasst von
P. Téoule
M. Distler
M. Niedergethmann
T. Gaiser
F. Rückert
R. Grützmann
T. J. Wilhelm
Publikationsdatum
01.08.2016
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 4/2016
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-015-0374-0