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01.06.2022 | DFP-Fortbildung

Restless-Legs-Syndrom: Klinik und Therapie

verfasst von: Prim. PD Dr. Nenad Mitrovic

Erschienen in: Schmerz Nachrichten | Ausgabe 2/2022

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Symptome des Restless-Legs-Syndroms (RLS) können durch viele unterschiedliche Faktoren ausgelöst und verschlechtert werden. Diese Faktoren frühzeitig zu erkennen und, wenn möglich, auch zu beseitigen, ist daher von entscheidender Bedeutung für den Therapieerfolg. Die meisten Patient*innen benötigen keine Pharmakotherapie, da ihre Symptome selten auftreten und auch mild ausgeprägt sind. Bei schwereren Verlaufsformen stehen gut wirksame Medikamente zur Verfügung, die zu einer deutlichen Besserung der Lebensqualität führen. …
Literatur
1.
Zurück zum Zitat Para KS, Chow CA, Nalamada K, et al. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Med. 2019;54:1–7.CrossRef Para KS, Chow CA, Nalamada K, et al. Suicidal thought and behavior in individuals with restless legs syndrome. Sleep Med. 2019;54:1–7.CrossRef
2.
Zurück zum Zitat Szentkirályi A, Fendrich K, Hoffmann W, et al. Incidence of restless legs syndrome in two population-based cohort studies in Germany. Sleep Med. 2011;12:815–20.CrossRef Szentkirályi A, Fendrich K, Hoffmann W, et al. Incidence of restless legs syndrome in two population-based cohort studies in Germany. Sleep Med. 2011;12:815–20.CrossRef
3.
Zurück zum Zitat Fulda S. Gender differences in the prevalence of restless legs syndrome/Willis-Ekbom disease. Somnologie. 2013;17:246–51.CrossRef Fulda S. Gender differences in the prevalence of restless legs syndrome/Willis-Ekbom disease. Somnologie. 2013;17:246–51.CrossRef
4.
Zurück zum Zitat Berger K, Luedemann J, Trenkwalder C, et al. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164:196–202.CrossRef Berger K, Luedemann J, Trenkwalder C, et al. Sex and the risk of restless legs syndrome in the general population. Arch Intern Med. 2004;164:196–202.CrossRef
5.
Zurück zum Zitat Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4:101–19.CrossRef Allen RP, Picchietti D, Hening WA, et al. Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med. 2003;4:101–19.CrossRef
6.
Zurück zum Zitat Allen RP, Earley CJ. The role of iron in restless legs syndrome. Mov Disord. 2007;22(18):440–8.CrossRef Allen RP, Earley CJ. The role of iron in restless legs syndrome. Mov Disord. 2007;22(18):440–8.CrossRef
7.
Zurück zum Zitat Rizzo G, Manners D, Testa C, et al. Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. Mov Disord. 2013;28(13):1886–90.CrossRef Rizzo G, Manners D, Testa C, et al. Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. Mov Disord. 2013;28(13):1886–90.CrossRef
8.
Zurück zum Zitat Schormair B, Zhao C, Bell S, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. 2017;16(11):898.CrossRef Schormair B, Zhao C, Bell S, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. 2017;16(11):898.CrossRef
9.
Zurück zum Zitat Giannaki CD, Hadjigeorgiou GM, Karatzaferi C, et al. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int. 2014;85(6):1275–82.CrossRef Giannaki CD, Hadjigeorgiou GM, Karatzaferi C, et al. Epidemiology, impact, and treatment options of restless legs syndrome in end-stage renal disease patients: an evidence-based review. Kidney Int. 2014;85(6):1275–82.CrossRef
10.
Zurück zum Zitat Huiqi Q, Shan L, Mingcai Q. Restless legs syndrome (RLS) in uremic patients is related to the frequency of hemodialysis sessions. Nephron. 2000;86(4):540.CrossRef Huiqi Q, Shan L, Mingcai Q. Restless legs syndrome (RLS) in uremic patients is related to the frequency of hemodialysis sessions. Nephron. 2000;86(4):540.CrossRef
11.
Zurück zum Zitat Azar SA, Hatefi R, Talebi M. Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplant Proc. 2007;39(4):1132–3.CrossRef Azar SA, Hatefi R, Talebi M. Evaluation of effect of renal transplantation in treatment of restless legs syndrome. Transplant Proc. 2007;39(4):1132–3.CrossRef
12.
Zurück zum Zitat Trenkwalder C, Benes H, Hornyak M et al. Restless Legs Syndrom (RLS) und Periodic Limb Movement Disorder (PLMD). 2012; Leitlinien der Deutschen Gesellschaft für Neurologie. Trenkwalder C, Benes H, Hornyak M et al. Restless Legs Syndrom (RLS) und Periodic Limb Movement Disorder (PLMD). 2012; Leitlinien der Deutschen Gesellschaft für Neurologie.
13.
Zurück zum Zitat Gemignani F, Marbini A, Di Giovanni G, et al. Charcot-Marie-Tooth disease type 2 with restless legs syndrome. Neurology. 1999;52(5):1064–6.CrossRef Gemignani F, Marbini A, Di Giovanni G, et al. Charcot-Marie-Tooth disease type 2 with restless legs syndrome. Neurology. 1999;52(5):1064–6.CrossRef
14.
Zurück zum Zitat Jimenez FJ, Alonso-Navaro H, Garcia-Martin E, et al. Association between restless legs syndrome and peripheral neuropathy: a systematic review and meta-analysis. Eur J Neurol. 2021;28(7):2423–42.CrossRef Jimenez FJ, Alonso-Navaro H, Garcia-Martin E, et al. Association between restless legs syndrome and peripheral neuropathy: a systematic review and meta-analysis. Eur J Neurol. 2021;28(7):2423–42.CrossRef
15.
Zurück zum Zitat Hartmann M, Pfister R, Pfadenhauer K. Restless legs syndrome associated with spinal cord lesions. J Neurol Neurosurg Psychiatry. 1999;66(5):688.CrossRef Hartmann M, Pfister R, Pfadenhauer K. Restless legs syndrome associated with spinal cord lesions. J Neurol Neurosurg Psychiatry. 1999;66(5):688.CrossRef
16.
Zurück zum Zitat Högl B, Frauscher B, Seppi K, et al. Transient restless legs syndrome after spinal anesthesia: a prospective study. Neurology. 2002;59:1705–7.CrossRef Högl B, Frauscher B, Seppi K, et al. Transient restless legs syndrome after spinal anesthesia: a prospective study. Neurology. 2002;59:1705–7.CrossRef
17.
Zurück zum Zitat Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria—history, rationale, description, and significance. Sleep Med. 2014;15:860–73.CrossRef Allen RP, Picchietti DL, Garcia-Borreguero D, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria—history, rationale, description, and significance. Sleep Med. 2014;15:860–73.CrossRef
18.
Zurück zum Zitat Cassel W, Kesper K, Bauer A, et al. Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome. Sleep Med. 2016;17:109–20.CrossRef Cassel W, Kesper K, Bauer A, et al. Significant association between systolic and diastolic blood pressure elevations and periodic limb movements in patients with idiopathic restless legs syndrome. Sleep Med. 2016;17:109–20.CrossRef
19.
Zurück zum Zitat Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12(1):61.CrossRef Montplaisir J, Boucher S, Poirier G, et al. Clinical, polysomnographic, and genetic characteristics of restless legs syndrome: a study of 133 patients diagnosed with new standard criteria. Mov Disord. 1997;12(1):61.CrossRef
20.
Zurück zum Zitat Ondo WG, Hurtig HI, Avidan AY, et al. Clinical features and diagnosis of restless legs syndrome and periodic limb movement disorder in adults. Uptodate. 2021 Ondo WG, Hurtig HI, Avidan AY, et al. Clinical features and diagnosis of restless legs syndrome and periodic limb movement disorder in adults. Uptodate. 2021
21.
Zurück zum Zitat Silber MH, Buchfuhrer MJ, Earley CJ, et al. The management of restless legs syndrome: an updated algorithm. Mayo Clin Proc. 2021;96(7):1921–37.CrossRef Silber MH, Buchfuhrer MJ, Earley CJ, et al. The management of restless legs syndrome: an updated algorithm. Mayo Clin Proc. 2021;96(7):1921–37.CrossRef
22.
Zurück zum Zitat Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: treatment of restless legs syndrome in adults. Neurology. 2016;87:2585–93.CrossRef Winkelman JW, Armstrong MJ, Allen RP, et al. Practice guideline summary: treatment of restless legs syndrome in adults. Neurology. 2016;87:2585–93.CrossRef
23.
Zurück zum Zitat Allen RP, Chen C, Garcia-Borreguero D, et al. Comparison of pregabalin with pramipexol for restless legs syndrome. N Engl J Med. 2014;370:621–31.CrossRef Allen RP, Chen C, Garcia-Borreguero D, et al. Comparison of pregabalin with pramipexol for restless legs syndrome. N Engl J Med. 2014;370:621–31.CrossRef
24.
Zurück zum Zitat Cornelius JR, Tippmann-Peikert M, Slocumb NL, et al. Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study. Sleep. 2010;33(1):81–7.PubMedPubMedCentral Cornelius JR, Tippmann-Peikert M, Slocumb NL, et al. Impulse control disorders with the use of dopaminergic agents in restless legs syndrome: a case-control study. Sleep. 2010;33(1):81–7.PubMedPubMedCentral
25.
Zurück zum Zitat RELOXYN Study Group, Oertel WH, Hallstrom Y, Saletu-Zyhlarz GM, et al. Sleep and quality of life under prolongered release oxycodone/ naloxone for severe restless legs syndrome: an analysis of secondary efficacy variables of a double-blind, randomized, placebo-controlled study with an open-label extension. CNS Drugs. 2016;30(8):749–60.CrossRef RELOXYN Study Group, Oertel WH, Hallstrom Y, Saletu-Zyhlarz GM, et al. Sleep and quality of life under prolongered release oxycodone/ naloxone for severe restless legs syndrome: an analysis of secondary efficacy variables of a double-blind, randomized, placebo-controlled study with an open-label extension. CNS Drugs. 2016;30(8):749–60.CrossRef
26.
Zurück zum Zitat Oertel W, Trenkwalder C, Benes H, et al. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study. Lancet Neurol. 2011;10(8):710–20.CrossRef Oertel W, Trenkwalder C, Benes H, et al. Long-term safety and efficacy of rotigotine transdermal patch for moderate-to-severe idiopathic restless legs syndrome: a 5-year open-label extension study. Lancet Neurol. 2011;10(8):710–20.CrossRef
Metadaten
Titel
Restless-Legs-Syndrom: Klinik und Therapie
verfasst von
Prim. PD Dr. Nenad Mitrovic
Publikationsdatum
01.06.2022
Verlag
Springer Vienna
Erschienen in
Schmerz Nachrichten / Ausgabe 2/2022
Print ISSN: 2076-7625
Elektronische ISSN: 2731-3999
DOI
https://doi.org/10.1007/s44180-022-00040-z

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