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01.04.2014 | perspective | Ausgabe 7-8/2014 Open Access

Wiener klinische Wochenschrift 7-8/2014

Reporting bias in trials of volume resuscitation with hydroxyethyl starch

Wiener klinische Wochenschrift > Ausgabe 7-8/2014
MD Prof. Christian J. Wiedermann


The possibility of renal damage by hydroxyethyl starch has become the focus of intensive dispute based on the findings of published large trials. The aim of this narrative review is to analyze outcome reporting bias in the literature on volume resuscitation, focusing on selective outcome reporting in published randomized and observational trials with “modern” hydroxyethyl starch as therapeutic intervention. Three recent publications claimed to confirm renal safety of hydroxyethyl starch 130/0.4 for indications in severe sepsis, trauma, and critical illness, respectively. Selective outcome reporting was identified in these studies including underreporting of side effects and change of primary study outcomes. In conclusion, selective outcome reporting bias is identified in recent publications of clinical trials on volume resuscitation with HES.

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