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Erschienen in: Wiener klinische Wochenschrift 7-8/2021

28.12.2020 | original article

Relationship between serum osteopontin levels and the severity of COVID-19 infection

verfasst von: Associate Professor Ceyhun Varım, Assistant Professor Taner Demirci, Hasret Cengiz, Associate Professor İlhan Hacıbekiroğlu, Fatima Betul Tuncer, Erdem Çokluk, Hande Toptan, Professor Oguz Karabay, İlhan Yıldırım

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 7-8/2021

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Summary

Background

Coronavirus disease 2019 (COVID-19) is an acute inflammatory respiratory disease. Osteopontin (OPN) is a glycoprotein expressed in various cell types, such as bone, immune, smooth muscle, epithelial and endothelial cells. It also acts as a regulator of immune response. The aim of the present study was to reveal the place of serum osteopontin levels in predicting severity among patients with COVID-19.

Methods

This study included 84 patients, 43 female and 45 male. Patients were divided into 2 groups, group 1 non-severe group (n: 48), group 2 severe (n: 40). Demographic data, neutrophil, lymphocyte, platelet, white blood cell counts, albumin, procalcitonin, C‑reactive protein (CRP) and OPN levels were recorded. The OPN levels and these inflammatory parameters of the two groups were compared.

Results

There were no significant differences in terms of gender (female/male 25/23 vs. 18/22) and platelet count (178 K/μL vs. 191 K/μL) between the groups (p > 0.05). Ages (57.7 ± 17.0 years vs. 71.4 ± 12.8 years), procalcitonin (0.07 vs. 0.24 ng/mL), CRP (17 vs 158 mg/l), neutrophil count (3.7 vs 5.64 K/μL), WBC counts (5.38 vs 7.85 K/μL) and number of deaths (0 vs 26) (p < 0.001). The OPN levels (98.5 vs 13.75 ng/mL, p = 0.002) were found to be statistically higher, in group 2 than group 1.

Conclusion

The present study showed that OPN can be used to predict the severity in patients with COVID-19.
Literatur
1.
Zurück zum Zitat Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group. bioRxiv. 2020. Gorbalenya AE, Baker SC, Baric RS, et al. Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group. bioRxiv. 2020.
5.
Zurück zum Zitat Fisher LW, Whitson SW, Avioli LV, Termine JD. Matrix sialoprotein of developing bone. J Biol Chem. 1983;258(20):12723–7. CrossRefPubMed Fisher LW, Whitson SW, Avioli LV, Termine JD. Matrix sialoprotein of developing bone. J Biol Chem. 1983;258(20):12723–7. CrossRefPubMed
Metadaten
Titel
Relationship between serum osteopontin levels and the severity of COVID-19 infection
verfasst von
Associate Professor Ceyhun Varım
Assistant Professor Taner Demirci
Hasret Cengiz
Associate Professor İlhan Hacıbekiroğlu
Fatima Betul Tuncer
Erdem Çokluk
Hande Toptan
Professor Oguz Karabay
İlhan Yıldırım
Publikationsdatum
28.12.2020
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 7-8/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-020-01789-5