Skip to main content

Tipp

Weitere Artikel dieser Ausgabe durch Wischen aufrufen

Erschienen in: European Surgery 2/2016

01.04.2016 | Original Article

Relationship between atrophic gastritis, gastric intestinal metaplasia and Helicobacter pylori on endoscopic screening of upper gastrointestinal tract and a brief review of the literature

Endoscopic screening of upper gastrointestinal tract for gastric mucosal disorders

verfasst von: MD M. Z. Üçüncü, MD E. Kabul Gürbulak, MD B. Gürbulak, MD O. A. Savaş, MD B. Özütürk, MD A. C. Dural, MD A. Haşlak

Erschienen in: European Surgery | Ausgabe 2/2016

Einloggen, um Zugang zu erhalten
share
TEILEN

Summary

Objective

Gastric cancer mortality rates have been declining in Japan and Korea where gastric cancer is common, but mass screening programs are being conducted. However, this practice is difficult to implement in some countries with low gastric cancer incidence because of the expenses. Thus, the screening and following of high-risk patients should be performed at those countries where the patients entail high costs of time and money. The aim of our study is to determine the gastric cancer-related risk factors such as atrophic gastritis (AG) and intestinal metaplasia (IM), to identify high-risk patients in our region, to evaluate the relationship between the disease and Helicobacter pylori (H. pylori), as well as other risk factors and short-term results.

Patients and methods

Endoscopic, and histological biopsy results of 3096 patients, who had upper endoscopy because of upper gastrointestinal symptoms such as epigastric pain and dyspepsia, were retrospectively reviewed. All of these endoscopies had been performed between 2012 and 2014 in the endoscopy unit of our hospital.

Results

In total, 382 IM cases were found. A high correlation was observed between H. pylori positive patients and female gender (p = 0.02) and a significant association was detected between H. pylori negativity and IM (p = 0.001). While a high significant relation was revealed between female gender (p < 0.0001) and IM, a significant inverse relationship was detected between IM and AG (p = 0.001). The existence of H. pylori organism and being over the age of 40 were stated as significant risk factor for IM. After treatment of these patients, a significant decline was observed in IM.

Conclusion

Endoscopic diagnosis and histopathological verification of AG and IM, evaluating related risk factors, identifying high-risk patients, and inclusion of the individuals into treatment and screening programs are important in terms of preventive medicine.
Literatur
1.
Zurück zum Zitat Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008. GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917. CrossRefPubMed Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008. GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893–917. CrossRefPubMed
2.
Zurück zum Zitat Oliveira C, Seruca R, Carneiro F. Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol 2006 Jan;14(1):21–33. CrossRef Oliveira C, Seruca R, Carneiro F. Genetics, pathology, and clinics of familial gastric cancer. Int J Surg Pathol 2006 Jan;14(1):21–33. CrossRef
3.
Zurück zum Zitat Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108. CrossRefPubMed Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108. CrossRefPubMed
4.
Zurück zum Zitat Tepes B. Can gastric cancer be prevented? J Physiol Pharmacol. 2009;60(7):71–7. PubMed Tepes B. Can gastric cancer be prevented? J Physiol Pharmacol. 2009;60(7):71–7. PubMed
5.
Zurück zum Zitat Yoon H, Kim N, Lee HS, Shin CM, Park YS, Lee DH, et al. Helicobacter pylori-negative gastric cancer in South Korea. incidence and clinicopathologic characteristics. Helicobacter. 2011;16(5):382–8. CrossRefPubMed Yoon H, Kim N, Lee HS, Shin CM, Park YS, Lee DH, et al. Helicobacter pylori-negative gastric cancer in South Korea. incidence and clinicopathologic characteristics. Helicobacter. 2011;16(5):382–8. CrossRefPubMed
6.
Zurück zum Zitat Testino G. Gastric preneoplastic changes. Recenti Prog Med. 2004;95(5):239–44. PubMed Testino G. Gastric preneoplastic changes. Recenti Prog Med. 2004;95(5):239–44. PubMed
7.
Zurück zum Zitat Shin CM, Kim N, Lee HS, Lee HE, Lee SH, Park YS, et al. Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia. Helicobacter. 2009;14(6):512–9. CrossRefPubMed Shin CM, Kim N, Lee HS, Lee HE, Lee SH, Park YS, et al. Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia. Helicobacter. 2009;14(6):512–9. CrossRefPubMed
8.
Zurück zum Zitat Yoo JY, Kim N, Park YS, Hwang JH, Kim JW, Jeong SH, et al. Detection rate of Helicobacter pylori against a background of atrophic gastritis and/or intestinal metaplasia. J Clin Gastroenterol. 2007;41(8):751–5. CrossRefPubMed Yoo JY, Kim N, Park YS, Hwang JH, Kim JW, Jeong SH, et al. Detection rate of Helicobacter pylori against a background of atrophic gastritis and/or intestinal metaplasia. J Clin Gastroenterol. 2007;41(8):751–5. CrossRefPubMed
9.
Zurück zum Zitat Arkkila PE, Seppälä K, Färkkilä MA, Veijola L, Sipponen P. Helicobacter pylori eradication in the healing of atrophic gastritis: a one-year prospective study. Scand J Gastroenterol. 2006;41(7):782–90. CrossRefPubMed Arkkila PE, Seppälä K, Färkkilä MA, Veijola L, Sipponen P. Helicobacter pylori eradication in the healing of atrophic gastritis: a one-year prospective study. Scand J Gastroenterol. 2006;41(7):782–90. CrossRefPubMed
10.
Zurück zum Zitat Toyokawa T, Suwaki K, Miyake Y, Nakatsu M, Ando M. Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia. especially in the elderly population: a long-term prospective cohort study. J Gastroenterol Hepatol. 2010;25(3):544–7. CrossRefPubMed Toyokawa T, Suwaki K, Miyake Y, Nakatsu M, Ando M. Eradication of Helicobacter pylori infection improved gastric mucosal atrophy and prevented progression of intestinal metaplasia. especially in the elderly population: a long-term prospective cohort study. J Gastroenterol Hepatol. 2010;25(3):544–7. CrossRefPubMed
11.
Zurück zum Zitat de Vries AC, Haringsma J, Kuipers EJ. The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection. Helicobacter. 2007;12(1):1–15. CrossRefPubMed de Vries AC, Haringsma J, Kuipers EJ. The detection, surveillance and treatment of premalignant gastric lesions related to Helicobacter pylori infection. Helicobacter. 2007;12(1):1–15. CrossRefPubMed
12.
Zurück zum Zitat Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808–25 Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102(8):1808–25
13.
Zurück zum Zitat Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, Lunet N. Smoking and gastric cancer. systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008;19(7):689–701. CrossRefPubMed Ladeiras-Lopes R, Pereira AK, Nogueira A, Pinheiro-Torres T, Pinto I, Santos-Pereira R, Lunet N. Smoking and gastric cancer. systematic review and meta-analysis of cohort studies. Cancer Causes Control. 2008;19(7):689–701. CrossRefPubMed
14.
Zurück zum Zitat Zhang Z, Xu G, Ma M, Yang J, Liu X. Dietary fiber intake reduces risk for gastric cancer. a meta-analysis. Gastroenterology. 2013;145(1):113–20. CrossRefPubMed Zhang Z, Xu G, Ma M, Yang J, Liu X. Dietary fiber intake reduces risk for gastric cancer. a meta-analysis. Gastroenterology. 2013;145(1):113–20. CrossRefPubMed
15.
Zurück zum Zitat Rokkas T, Sechopoulos P, Pistiolas D, Margantinis G, Koukoulis G. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients. a meta-analysis. Eur J. Gastroenterol Hepatol. 2010;22(9):1128–33. CrossRefPubMed Rokkas T, Sechopoulos P, Pistiolas D, Margantinis G, Koukoulis G. Helicobacter pylori infection and gastric histology in first-degree relatives of gastric cancer patients. a meta-analysis. Eur J. Gastroenterol Hepatol. 2010;22(9):1128–33. CrossRefPubMed
16.
Zurück zum Zitat Joo YE, Park HK, Myung DS, Baik GH, Shin JE, Seo GS, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia. a nationwide multicenter prospective study in Korea. Gut Liver. 2013;7(3):303–10. CrossRefPubMedPubMedCentral Joo YE, Park HK, Myung DS, Baik GH, Shin JE, Seo GS, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia. a nationwide multicenter prospective study in Korea. Gut Liver. 2013;7(3):303–10. CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Chen Y, Liu L, Wang X, Wang J, Yan Z, Cheng J, et al. Body mass index and risk of gastric cancer. a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer Epidemiol Biomarkers Prev. 2013;22(8):1395–408. CrossRefPubMed Chen Y, Liu L, Wang X, Wang J, Yan Z, Cheng J, et al. Body mass index and risk of gastric cancer. a meta-analysis of a population with more than ten million from 24 prospective studies. Cancer Epidemiol Biomarkers Prev. 2013;22(8):1395–408. CrossRefPubMed
18.
Zurück zum Zitat Eshmuratov A, Nah JC, Kim N, Lee HS, Lee HE, Lee BH, et al. The correlation of endoscopic and histological diagnosis of gastric atrophy. Dig Dis Sci. 2010;55(5):1364–75. CrossRefPubMed Eshmuratov A, Nah JC, Kim N, Lee HS, Lee HE, Lee BH, et al. The correlation of endoscopic and histological diagnosis of gastric atrophy. Dig Dis Sci. 2010;55(5):1364–75. CrossRefPubMed
19.
Zurück zum Zitat Kim N, Park YS, Cho SI, Lee HS, Choe G, Kim IW, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter. 2008;13(4):245–55. CrossRefPubMed Kim N, Park YS, Cho SI, Lee HS, Choe G, Kim IW, et al. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter. 2008;13(4):245–55. CrossRefPubMed
20.
Zurück zum Zitat Ohata H, Kitauchi S, Yoshimura N, Mugitani K, Iwane M, Nakamura H, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 2004;109(1):138–43. CrossRefPubMed Ohata H, Kitauchi S, Yoshimura N, Mugitani K, Iwane M, Nakamura H, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 2004;109(1):138–43. CrossRefPubMed
21.
Zurück zum Zitat Kaise M, Miwa J, Tashiro J, Ohmoto Y, Morimoto S, Kato M, et al. The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk. J Gastroenterol. 2011;46(6):736–45. CrossRefPubMed Kaise M, Miwa J, Tashiro J, Ohmoto Y, Morimoto S, Kato M, et al. The combination of serum trefoil factor 3 and pepsinogen testing is a valid non-endoscopic biomarker for predicting the presence of gastric cancer: a new marker for gastric cancer risk. J Gastroenterol. 2011;46(6):736–45. CrossRefPubMed
22.
Zurück zum Zitat Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, et al. The benefit of mass eradication of Helicobacter pylori infection. a community-based study of gastric cancer prevention. Gut. 2013;62(5):676–82. CrossRefPubMedPubMedCentral Lee YC, Chen TH, Chiu HM, Shun CT, Chiang H, Liu TY, et al. The benefit of mass eradication of Helicobacter pylori infection. a community-based study of gastric cancer prevention. Gut. 2013;62(5):676–82. CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter. 2007;12(2):32–8. CrossRefPubMed Rokkas T, Pistiolas D, Sechopoulos P, Robotis I, Margantinis G. The long-term impact of Helicobacter pylori eradication on gastric histology: a systematic review and meta-analysis. Helicobacter. 2007;12(2):32–8. CrossRefPubMed
24.
Zurück zum Zitat Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL et al; Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008;9(3):279–87. CrossRefPubMed Leung WK, Wu MS, Kakugawa Y, Kim JJ, Yeoh KG, Goh KL et al; Asia Pacific Working Group on Gastric Cancer. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol. 2008;9(3):279–87. CrossRefPubMed
Metadaten
Titel
Relationship between atrophic gastritis, gastric intestinal metaplasia and Helicobacter pylori on endoscopic screening of upper gastrointestinal tract and a brief review of the literature
Endoscopic screening of upper gastrointestinal tract for gastric mucosal disorders
verfasst von
MD M. Z. Üçüncü
MD E. Kabul Gürbulak
MD B. Gürbulak
MD O. A. Savaş
MD B. Özütürk
MD A. C. Dural
MD A. Haşlak
Publikationsdatum
01.04.2016
Verlag
Springer Vienna
Erschienen in
European Surgery / Ausgabe 2/2016
Print ISSN: 1682-8631
Elektronische ISSN: 1682-4016
DOI
https://doi.org/10.1007/s10353-015-0378-9

Weitere Artikel der Ausgabe 2/2016

European Surgery 2/2016 Zur Ausgabe