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01.03.2015 | original article | Ausgabe 5-6/2015

Wiener klinische Wochenschrift 5-6/2015

Relation of fragmented QRS to tissue Doppler-derived parametersin patients with familial Mediterranean fever

Wiener klinische Wochenschrift > Ausgabe 5-6/2015
MD Assoc. Prof. Muhammet Murat Celik, MD Assoc. Prof. Eyup Buyukkaya, MD Asst. Prof. Nilgul Ustun, MD Asst. Prof. Alper Bugra Nacar, MD Assoc. Prof. Mustafa Kurt, MD Asst. Prof. Mehmet Fatih Karakas, MD Perihan Bilen, MD Prof. Mehmet Duru, MD Assoc. Prof. Nihat Sen, MD Assoc. Prof. Adnan Burak Akcay
Wichtige Hinweise
This study was presented as abstracts of the 29th Turkish Cardiology Congress of Turkish Society of Cardiology with International Participation. October 26–29, 2013, Antalya, Turkey. Journal of the American College of Cardiology. 2013;62(18_S2):C180. doi:10.1016/j.jacc.2013.08.509.



Familial Mediterranean fever (FMF) may pose a risk for cardiovascular diseases due to continuous inflammatory status observed during the course of the disease. Recently, the presence of fragmented QRS (fQRS) has been recognized as a predictor of myocardial fibrosis. In this study, we aim to investigate the frequency of fQRS and its relation to Doppler-based indices.


This study consisted of 80 FMF patients and 30 healthy control subjects. fQRS pattern was defined as the presence of additional R waves or RSR’, evidenced by notched R or S wave on electrocardiography (ECG). The patient and the control groups underwent conventional echocardiography and tissue Doppler echocardiography.


There was no significant difference between groups regarding age (29 ± 12 vs 29 ± 15). FMF patients exhibited a statistically higher frequency of fQRS (% 56 vs % 13) (p < 0.01). E/Em ratio showed a statistically significant increase in the FMF group with fQRS (p < 0.0001), while the mean Em value was markedly lower (p < 0.0001).


FMF patients displayed a statistically significant increase in frequency of fQRS. Doppler-derived diastolic index was statistically significantly impaired in FMF patients with fQRS as compared with the patients without fQRS. In conclusion, fQRS might be a new noninvasive marker for cardiac involvement in FMF patients.

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