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22.10.2020 | case report | Ausgabe 6/2020

European Surgery 6/2020

Refractory hypoglycemia associated with giant solitary fibrous tumor of the pleura (Doege–Potter syndrome)

European Surgery > Ausgabe 6/2020
Carlo Alberto Manzo, Emanuele Asti, Caterina Froiio, Barbara Bruni, MD Luigi Bonavina
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The association of a solitary tumor of the pleura with paraneoplastic refractory hypoglycemia is a very rare clinical condition.


An 86-year-old gentleman with an incidentally discovered large mass in the left chest and a long-standing history of refractory hypoglycemia was referred for surgical consultation. Computed tomography and PET (Positron Emission Tomography) scan confirmed the presence of a homogeneous mass leaning on the left hemidiaphragm with no tracer uptake.


After tumor board discussion, the mass was radically excised through a left thoracotomy. Histopathology revealed a benign solitary fibrous tumor of the pleura. At 1‑year follow-up the patient was doing well and did not further complain of hypoglycemia-related symptoms.


Doege–Potter syndrome is a life-threatening condition associated with severely impaired quality of life. Prompt identification and surgical treatment are mandatory.

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